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Reassessing forebrain organization: recent evidence challenges the prosomere model
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Mechanobiology of cardiac regeneration
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Wound-triggered plasticity in plant regeneration
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SOX9 as a key regulator of tissue remodelling and epithelial cell fate transitions
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RNA signaling in cellular plasticity during homeostasis and regeneration
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Promises of reprogramming-induced rejuvenation
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Lineage tracing in gastruloids to understand determinants of early fate decisions
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Decoding and engineering 3D chromatin interactions governing pluripotent and totipotent cell states
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ETV2 for endothelial fate specification
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An integrated transcriptional regulation from zygotic genome activation to the first lineage segregation
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Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy
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Long-term evolution of regulatory DNA sequences. Part 1: simulations on global, biophysically-realistic genotype–phenotype maps
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Active processes shape and move the genome and nucleoplasm
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Somatic mosaicism in hypothalamic hamartoma
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Somatic variation in multiple sclerosis: from blood to brain
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Tracing cell lineages in the developing brain: Insights from mosaic analysis and clone-resolved transcriptomics
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Beyond the gene: isoform diversity as a key contributor to human brain disorders
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Progress toward complete cell-type and spatial-resolution atlases of the developing brain
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GABAergic neuron fate specification and lineage allocation: from development to disorder
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Cis-regulatory strategies in developmental patterning
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Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity
Jianlong Wang is a tenured Professor of Medicine at Columbia University Irving Medical Center and a core faculty member of...
Centromere regulation in the germline and early embryo
Centromeres are essential for genome inheritance, serving as sites for kinetochore assembly and for final sister chromatid...
Why and how paternal mitochondrial DNA gets cut out of the inheritance
Mitochondrial DNA (mtDNA) is inherited maternally across animals, yet the evolutionary rationale behind this unusual mode ...
Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice
Germ cells are unique in their ability to acquire totipotency. Toward this end, they reorganize their three-dimensional (3...
Transcription-coupled repair: protecting genome across generations
The primary objective of life is to ensure the faithful transmission of genetic material across generations, despite the c...
Genome instability in mammalian embryos implications for genome editing, development, and evolution
Genomic instability is a significant challenge in early mammalian development and a cause for developmental failure and ab...
Transcription-Export complex in neurodevelopmental disorders
The genomic information is insulated in the nucleus of all eukaryotic cells. Error-free transcription needs to be followed...
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA decay mechanism that serves the purpose of controlling ...
Evolution and ecology of commensal gut protists: recent advances
The microbial community colonizing the animal gut includes all domains of life, including eukaryotic microbes. Historicall...
Linking phenotype to genotype using comprehensive genomic comparisons
Comparative genomics is a powerful approach to illuminate the genetic basis of phenotypic diversity across macro-evolution...
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