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Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity
Jianlong Wang is a tenured Professor of Medicine at Columbia University Irving Medical Center and a core faculty member of...
Centromere regulation in the germline and early embryo
Centromeres are essential for genome inheritance, serving as sites for kinetochore assembly and for final sister chromatid...
Why and how paternal mitochondrial DNA gets cut out of the inheritance
Mitochondrial DNA (mtDNA) is inherited maternally across animals, yet the evolutionary rationale behind this unusual mode ...
Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice
Germ cells are unique in their ability to acquire totipotency. Toward this end, they reorganize their three-dimensional (3...
Transcription-coupled repair: protecting genome across generations
The primary objective of life is to ensure the faithful transmission of genetic material across generations, despite the c...
Genome instability in mammalian embryos implications for genome editing, development, and evolution
Genomic instability is a significant challenge in early mammalian development and a cause for developmental failure and ab...
Transcription-Export complex in neurodevelopmental disorders
The genomic information is insulated in the nucleus of all eukaryotic cells. Error-free transcription needs to be followed...
Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA decay mechanism that serves the purpose of controlling ...
Evolution and ecology of commensal gut protists: recent advances
The microbial community colonizing the animal gut includes all domains of life, including eukaryotic microbes. Historicall...
Linking phenotype to genotype using comprehensive genomic comparisons
Comparative genomics is a powerful approach to illuminate the genetic basis of phenotypic diversity across macro-evolution...
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks
Comparative transcriptomic studies are key to understanding how molecular evolution drives phenotypic divergence across th...
Polygenic prediction of human complex traits using ancient DNA
Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molec...
Behavioral evolution by diverging cell type composition
Recent advances in single-cell genomics are propelling a flurry of discoveries about the cellular composition of the brain...
Human gut evolution: insights from stem cell models and single-cell genomics
The gastrointestinal (GI) tract evolved in response to dietary changes and pathogen exposures that varied throughout histo...
Evolutionary genetics meets ecological immunology: insights into the evolution of immune systems
Immune genes show remarkably consistent evidence of selection, modification, and diversification across the tree of life. ...
New methodological approaches and insights gained toward understanding the evolved human skeleton
Humans exhibit marked musculoskeletal changes compared to their African ape relatives, such as chimpanzees, bonobos, and g...
Epistatic drift in protein evolution
New methods are revealing the character of epistatic interactions within proteins and their impacts on evolution. Variatio...
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation
ADNPActivity Dependent Neuroprotector HomeoboxCACapsidCRECis-regulatory elementCTDC-Terminal DomainDBDDNA binding domainDU...
Editorial Overview: Developmental mechanisms patterning and evolution (2025)
Yukiko Yamashita is a professor at Massachusetts Institute of Technology and a member of the Whitehead Institute for Biome...
Editorial overview: Molecular and genetic basis of disease (2025): post-transcriptional regulation of neurodevelopment and associated disorders
Dr. Naiara Akizu is associate professor of Pathology and Laboratory Medicine at the Childrens’ Hospital of Philadelphia an...
Fine-tuned programming of placenta trophoblast determines optimal maternal–fetal nutrient allocation
The placenta, a temporary organ, is pivotal for fetal growth and health by enabling the exchange of nutrients and waste be...
Recent insights into the in vitro culture systems for mammalian embryos
Early embryonic development is crucial for individual health. Abnormal early embryonic development may lead to early pregn...
Insights and Interventions in Age-Associated Inflammation
Aging is a systemic, complex, and heterogeneous process characterized by a progressive decline in physiological functions,...
Decoding N6-methyladenosine’s dynamic role in stem cell fate and early embryo development: insights into RNA–chromatin interactions
The epitranscriptome, also known as RNA epigenetics, refers to the collection of chemical modifications on RNA molecules t...
Modeling forebrain regional development and connectivity by human brain organoids
Brain organoids are powerful research tools with a wide range of applications, including disease modeling, drug developmen...
Editorial overview: Regaining architecture and cell cross-talk upon regeneration
D. Jonathan Yuin-Han Loh is Research Director at the Institute of Molecular and Cell Biology and Professor (Adj) at the Na...
Exploring the connection between RNA splicing and intellectual disability
Intellectual disability (ID) is a broad diagnostic category that encompasses individuals with impaired cognitive ability. ...
Bridging spatial and temporal scales of developmental gene regulation
The development of multicellular organisms relies on the precise coordination of molecular events across multiple spatial ...
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe
Olfaction, the detection and identification of volatile chemicals, is a primal sense essential for animal survival, reprod...
Editorial overview: Peering into our history through a genetic lens: How advances in genetics are changing our understanding of human evolution
Jason L Stein is an Associate Professor in the Department of Genetics and UNC Neuroscience Center at the University of Nor...
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