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Predicting the regulatory genome
Deep learning models have made impressive strides in decoding the regulatory genome, but key challenges remain unsolved. I...
A clinical milestone for CRISPR in sickle-cell disease
A clinical milestone for CRISPR in sickle-cell disease
Gerald Mboowa reflects on the dual legacy of a 2021 study by Frangoul et al., which demonstrated safe and effective CRISPR...
Spatial architecture of development and disease
Spatial architecture of development and disease
Tissue architecture is a product of a multilayered molecular landscape, where even subtle disruptions in the spatial conte...
The evolution of Mycobacterium tuberculosis as humans migrated out of Africa
Sara Suliman describes a seminal 2013 publication by Comas et al. that investigated the origins of the tuberculosis-causin...
Forensic genetics in the omics era
Forensic genetics in the omics era
Recent advances in forensic genetics, driven by technological innovation coupled with the use of an expanding range of nuc...
Clinical use of polygenic risk scores: current status, barriers and future directions
Clinical use of polygenic risk scores: current status, barriers and future directions
Genome-wide association studies have identified thousands of single-nucleotide variants that are associated with complex t...
The early days of transcriptome sequencing and functional genomics
Ayako Suzuki recalls two papers published in the early 2000s by the Functional Annotation of the Mammalian Genome (FANTOM)...
Spatial metabolomics to unravel cellular metabolism
Spatial metabolomics to unravel cellular metabolism
In this Tools of the Trade article, Arafath Najumudeen and Johan Vande Voorde showcase the potential of mass spectrometry ...
Integrating ELSI study teams in paediatric genomic research efforts
Addressing ethical, legal and social implications (ELSI) in genomics requires early integration of specialized teams to en...
Spatial miRNomics: towards the integration of microRNAs in spatial biology
Spatial transcriptomics tools enable the detection and localization of hundreds to thousands of transcripts in biological ...
Genomic data sharing: you don’t know what you’ve got (till it’s gone)
Genomics research has thrived under a culture of data sharing, formalized during the genome-project era. As the field̵...
Tracking protein binding to cis-regulatory elements with PRINT
Tracking protein binding to cis-regulatory elements with PRINT
In this Tools of the Trade article, Yan Hu explains the development and application of PRINT and seq2PRINT, computational ...
Decoding cell–cell communication using spatial transcriptomics
Decoding cell–cell communication using spatial transcriptomics
In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which i...
Intrinsically disordered regions as facilitators of the transcription factor target search
Intrinsically disordered regions as facilitators of the transcription factor target search
Transcription factors (TFs) contribute to organismal development and function by regulating gene expression. Despite decad...
Decoding human genetic variation using a synthetic paradigm
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of &...
Divergence and conservation of the meiotic recombination machinery
Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during ...
Including diverse populations enhances the discovery of type 2 diabetes loci
Segun Fatumo highlights a paper by Mahajan et al. that uses a multi-ancestry genome-wide association studies approach to u...
Mouse genome rewriting with human DNA for disease modelling
Mouse genome rewriting with human DNA for disease modelling
Zhang et al. describe mSwAP-In, a platform for large-scale, efficient, biallelic and ‘scarless’ genome editing...
Weaponized genomics: potential threats to international and human security
Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussi...
Context-specific functions of chromatin remodellers in development and disease
Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human gen...
SWI/SNF function compensated by another chromatin remodeller
SWI/SNF function compensated by another chromatin remodeller
Martin et al. report that the EP400/TIP60 complex can compensate for function of the SWI/SNF complex to remodel chromatin ...
Translating genomic advances into biodiversity conservation
Translating genomic advances into biodiversity conservation
A key action of the new Global Biodiversity Framework is the maintenance of genetic diversity in all species to safeguard ...
Interrogating epigenetic mechanisms with chemically customized chromatin
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated i...
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. S...
Controlling organoid gene expression with light
Controlling organoid gene expression with light
Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can...
De novo genes: from non-genic to genic
Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially univ...
A genetic atlas of the human blood proteome
A genetic atlas of the human blood proteome
Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for unders...
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencin...
WNT regulator controls stripe patterning
WNT regulator controls stripe patterning
Johnson et al. identify a WNT regulator that underlies the development and evolution of distinct colour patterning in the ...
Genomics for monitoring and understanding species responses to global climate change
Genomics for monitoring and understanding species responses to global climate change
All life forms across the globe are experiencing drastic changes in environmental conditions as a result of global climate...
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