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Therapeutic approaches for targeting the pediatric brain tumor microenvironment
Therapeutic approaches for targeting the pediatric brain tumor microenvironment
Central nervous system (CNS) tumors are the most frequent solid malignant tumors in pediatric patients and are the leading...
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are st...
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Breast cancer is the most common cancer among women, with approximately 2.3 million new cases globally. Triple-negative br...
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Dementia includes a variety of neurodegenerative diseases that affect and target the brain’s fundamental cognitive f...
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
This study presents an emerging approach for oral peptide drug delivery by designing self-emulsifying drug delivery system...
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Pulmonary infections caused by bacteria, viruses and fungi are a significant global health issue. Inhalation therapies are...
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
Despite exhaustive investments, the breakthrough potential of nanomedicines (NM) is not yet realized. Whilst Doxil and cov...
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
A shift towards the subcutaneous (S.C.) delivery of protein therapeutics is enabling patient-centric at-home self-administ...
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Inflammation and impaired bone regeneration are major challenges in oral and maxillofacial surgery, necessitating the deve...
Post-encapsulation methods for the preparation of mRNA-LNPs
Post-encapsulation methods for the preparation of mRNA-LNPs
Microfluidics mixing is the current lab-scale method used for producing mRNA-loaded lipid nanoparticles (mRNA-LNPs) thanks...
Radiolabelling and bioequivalence of modified Tamoxifen solid lipid nanoparticles as a targeted chemotherapeutic drug
Radiolabelling and bioequivalence of modified Tamoxifen solid lipid nanoparticles as a targeted chemotherapeutic drug
There are several types of breast cancer where the breast's cells proliferate uncontrollably. A selective oestrogen re...
A framework for conducting clinical trials involving 3D printing of medicines at the point-of-care
A framework for conducting clinical trials involving 3D printing of medicines at the point-of-care
The integration of 3D printing (3DP) technologies into personalized medicine manufacture at the point-of-care is garnering...
Evaluation of ocular tolerability and bioavailability of tonabersat transfersomes ex vivo
Evaluation of ocular tolerability and bioavailability of tonabersat transfersomes ex vivo
While transfersomes (TFS) have extensively been investigated as carriers for topical drug delivery to the skin, their appl...
Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering
Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering
Despite current medicine’s fast-paced advances, many acute and chronic illnesses still lack truly effective and safe...
Synergy of dissolving microneedles and ultrasound to enhance transdermal delivery for rheumatoid arthritis
Synergy of dissolving microneedles and ultrasound to enhance transdermal delivery for rheumatoid arthritis
Dissolving microneedles (DMNs) are an emerging transdermal drug delivery system that has gained increasing attention as an...
Bovine colostrum–derived extracellular vesicles modulate gut microbiota and alleviate atopic dermatitis via the gut–skin axis
Bovine colostrum–derived extracellular vesicles modulate gut microbiota and alleviate atopic dermatitis via the gut–skin axis
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by immune dysregulation and a disrupted gut&...
Mitigating radioresistance mechanisms by polymer-lipid manganese dioxide nanoparticles enhances immunogenic cell death and antitumor immune response to facilitate abscopal effect in breast tumor models
Mitigating radioresistance mechanisms by polymer-lipid manganese dioxide nanoparticles enhances immunogenic cell death and antitumor immune response to facilitate abscopal effect in breast tumor models
Breast cancer is the most diagnosed cancer and the second leading cause of cancer death in women. Although treatments with...
Development of a hydrophilic transdermal patch for combined delivery of sumatriptan and metoclopramide in migraine therapy
Development of a hydrophilic transdermal patch for combined delivery of sumatriptan and metoclopramide in migraine therapy
Migraine, a prevalent neurological disorder, is known to significantly impact patients' quality of life. The effective...
Evaluation of proinsulin(F25D) as a targeting ligand for insulin-binding B cells in autoimmune diabetes
Evaluation of proinsulin(F25D) as a targeting ligand for insulin-binding B cells in autoimmune diabetes
Insulin-binding B cells are implicated in Type 1 Diabetes (T1D) pathology. Antigen-specific immunotherapy (ASIT) holds pro...
A patented portable multifunctional nebulizer for enhanced respiratory drug delivery: an experimental study
A patented portable multifunctional nebulizer for enhanced respiratory drug delivery: an experimental study
This study aimed to design and evaluate the clinical efficacy of a new patented portable multifunctional medical nebulizer...
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effe...
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
While considerable efforts have been made to develop new therapies, progress in the treatment of pancreatic cancer has so ...
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Cannabidiol (CBD) has gained significant attention as a complementary and alternative medicine due to its promising therap...
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Chronic and allergic rhinosinusitis impacts approximately 12% of the global population. Challenges in rhinosinusitis treat...
Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance
Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance
Cite this articleWang, S., Tan, X., Zhou, Q. et al. Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targete...
Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing
Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing
The leading cause of death worldwide and a significant factor in decreased quality of life are the cardiovascular diseases...
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Fluconazole (FLZ) has been widely used in the treatment of infection caused by Candida albicans, including the treatment o...
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of...
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alt...
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Lyophilization also known as freeze-drying is a technique that has been employed to enhance the long-term durability of na...
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