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Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial
Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial
Patients with cutaneous squamous cell carcinoma (CSCC) frequently require mutilating surgery and adjuvant radiotherapy (RT...
Ebola vaccine safe for mothers and infants
Ebola vaccine safe for mothers and infants
A clinical trial of pregnant women provides critical safety and immunogenicity data in support of a two-dose Ebola vaccine...
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study
Incorporating genomic sequencing into newborn screening will dramatically increase the number of detectable conditions but...
For trustworthy AI, keep the human in the loop
We call for more studies exploring the implementation of AI technologies and what happens when humans and AI interact in t...
Unlocking host response signatures in sepsis and critical illnesses
Unlocking host response signatures in sepsis and critical illnesses
Three studies that leverage blood-based gene expression data identify molecular and cellular host response signatures in s...
Developing cell therapies for lupus
Developing cell therapies for lupus
Two phase 1 studies report promising outcomes with chimeric antigen receptor (CAR) T cell therapies in patients with syste...
Modeling the threat of pfhrp2/3 gene deletions for malaria diagnosis
Modeling the threat of pfhrp2/3 gene deletions for malaria diagnosis
Malaria parasites that evade the most widely used rapid diagnostic tests are spreading. We combined new data and modeling ...
Rethinking India’s plate to improve metabolic health
Rethinking India’s plate to improve metabolic health
The ICMR-INDIAB survey of 18,090 adults revealed major differences in macronutrient intake across different regions in Ind...
Engineered heart muscle reinvigorates failing hearts
Engineered heart muscle reinvigorates failing hearts
Heart muscle grafts engineered from induced pluripotent stem cells enhanced cardiac function in rhesus macaques with heart...
Dementia prevention needs clinical trials
Interventions focused on disease prevention are a promising strategy for combating the rising incidence of dementia, but m...
Epigenetic footprints in prenatal cell-free DNA reveal risk of preeclampsia
Epigenetic footprints in prenatal cell-free DNA reveal risk of preeclampsia
We leveraged early-pregnancy prenatal cell-free DNA screening (PDNAS) sequencing data to determine tissue signatures assoc...
Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial
Reduced-energy diet in women with gestational diabetes: the dietary intervention in gestational diabetes DiGest randomized clinical trial
Reduced-energy diets promote weight loss and improve long-term outcomes in type 2 diabetes but are untested in gestational...
Integrating the environmental and genetic architectures of aging and mortality
Integrating the environmental and genetic architectures of aging and mortality
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quant...
Dual immunotherapy benefits certain patients with metastatic colorectal cancer
Dual immunotherapy benefits certain patients with metastatic colorectal cancer
The phase 3 CheckMate 8HW trial shows superior outcomes with nivolumab plus ipilimumab (compared with nivolumab monotherap...
Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody
Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody
Chimeric antigen receptor (CAR) T cells and bispecific T cell engagers have become integral components in the treatment of...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
Meningioma risk stratification with a targeted gene-expression biomarker
Meningioma risk stratification with a targeted gene-expression biomarker
A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningi...
11 clinical trials that will shape medicine in 2024
11 clinical trials that will shape medicine in 2024
Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine agains...
Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USASylvan C. Baca, Ji-Heui Seo, Matthew P. David...
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate...
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
KRAS G12C mutation is prevalent in ~4% of colorectal cancer (CRC) and is associated with poor prognosis. Divarasib, a KRAS...
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multice...
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of lif...
Monitoring medical AI device adoption
Monitoring medical AI device adoption
The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and l...
CT scans in young people and risk of hematological malignancies
CT scans in young people and risk of hematological malignancies
A study of nearly one million people who underwent a CT scan before 22 years of age finds that the radiation from CT scans...
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