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Pulmonary Artery Banding: an Effective in-vivo Acute Model of Functional Tricuspid Regurgitation for Transcatheter Interventions
Pulmonary Artery Banding: an Effective in-vivo Acute Model of Functional Tricuspid Regurgitation for Transcatheter Interventions
Tricuspid regurgitation (TR) is a highly morbid and often untreated valvular heart disease. New devices are under...
The Role of Testosterone in Atherosclerosis: View From Cell Cultures and Animal Models
The Role of Testosterone in Atherosclerosis: View From Cell Cultures and Animal Models
Testosterone (TES) has complex roles in cardiovascular disease, influencing not only atherosclerosis development in genera...
Exosomes Enhance Diagnosis and Therapy of Ischemic Heart Disease: Insights and Advances
Exosomes Enhance Diagnosis and Therapy of Ischemic Heart Disease: Insights and Advances
Ischemic heart disease is a leading cause of global morbidity and mortality, yet early diagnosis and targeted therapies re...
Translational Methods for Wearable Heart Rate Variability Monitoring in Older Adults: Preoperative Risk Stratification and Postoperative Monitoring
Translational Methods for Wearable Heart Rate Variability Monitoring in Older Adults: Preoperative Risk Stratification and Postoperative Monitoring
Low preoperative heart rate variability (HRV) is associated with adverse cardiovascular outcomes and delirium after geriat...
Neutrophil Extracellular Traps and Complement Pathways: The Missing Links in Acute Rheumatic Fever and Rheumatic Heart Disease Pathogenesis
Neutrophil Extracellular Traps and Complement Pathways: The Missing Links in Acute Rheumatic Fever and Rheumatic Heart Disease Pathogenesis
For decades, the pathogenesis of Acute Rheumatic Fever and Rheumatic Heart Disease has been primarily attributed to autoim...
Correlation Between Serum GDF11 Levels and the Progression of Ischemic Mitral Regurgitation and Long-term Prognosis in Patients with ST-segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention
Correlation Between Serum GDF11 Levels and the Progression of Ischemic Mitral Regurgitation and Long-term Prognosis in Patients with ST-segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention
Ischemic mitral regurgitation (IMR) commonly complicates pPCI in STEMI patients. GDF11, a protective cardiovascular factor...
Gene Therapy for Heart Failure
Gene Therapy for Heart Failure
Heart failure is the leading cause of hospitalization globally, burdening healthcare systems and the economy. Heart failur...
Transcription Factor SP1 Drives Myocardial Ischemia/reperfusion Injury By Transcription Activation-mediated GADD45G Upregulation
Transcription Factor SP1 Drives Myocardial Ischemia/reperfusion Injury By Transcription Activation-mediated GADD45G Upregulation
Myocardial ischemia–reperfusion injury (MIRI) is an unresolved clinically fatal complication in the management of ac...
MiR-499-5P/PACS2/TRPV1 Axis Maintains Mitochondrial Homeostasis and Left Ventricular Function after Extreme Cold Stress
MiR-499-5P/PACS2/TRPV1 Axis Maintains Mitochondrial Homeostasis and Left Ventricular Function after Extreme Cold Stress
Exposure to cold environments is physiologically challenging, with extreme cold stress (ECS) impairing the function of the...
PAD-associated Genetic Variants are More Strongly Associated with Surgical Intervention than Premature Onset
PAD-associated Genetic Variants are More Strongly Associated with Surgical Intervention than Premature Onset
This study explored the association between 19 peripheral artery disease (PAD)-associated variants and PAD severity. We cl...
Sustained Mechanical Occlusion of the Superior Vena Cava Safely Reduces Cardiac Filling Pressures in a Preclinical Model of Heart Failure
Sustained Mechanical Occlusion of the Superior Vena Cava Safely Reduces Cardiac Filling Pressures in a Preclinical Model of Heart Failure
Device-based therapies may augment decongestion in acute decompensated heart failure. We investigated the efficacy and saf...
Pressure Measurements Obtained from Intraosseous Access: Potential Clinical Applications Explored Using a Porcine Model
Pressure Measurements Obtained from Intraosseous Access: Potential Clinical Applications Explored Using a Porcine Model
Intraosseous access, the fastest access in emergencies, is exclusively used for delivering medications or fluids....
Computational Fluid Dynamics Simulation of Endothelium-Modulated Thrombosis
Computational Fluid Dynamics Simulation of Endothelium-Modulated Thrombosis
The development of blood-wetted artificial organs is limited by thrombosis on synthetic biomaterial surfaces. In contrast,...
Lacylation of Stearoyl-CoA Desaturase-1 Contributes to the Myocardial Ischemia–Reperfusion Injury Through Regulating Wnt/β-Catenin Signaling
Lacylation of Stearoyl-CoA Desaturase-1 Contributes to the Myocardial Ischemia–Reperfusion Injury Through Regulating Wnt/β-Catenin Signaling
Myocardial ischemia–reperfusion injury (MIRI) involves tissue damage following restoration of blood flow. Stearoyl-C...
Glucagon-like Peptide-1 Receptor Dependent Signaling in Cardiovascular Health and Disease: A Mini-review
Glucagon-like Peptide-1 Receptor Dependent Signaling in Cardiovascular Health and Disease: A Mini-review
Glucagon-like peptide-1 (GLP-1) is a hormone mainly produced by intestinal L cells after meal, and its main functions incl...
Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke
Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke
The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic s...
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock
The acute pathophysiological changes after myocardial ischemia complicated by cardiogenic shock (CS) remain poorly defined...
Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies
Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies
Small Interfering RNA (siRNA) is a class of double-stranded, noncoding RNA that silences pathogenic mRNA through the proce...
Intracoronary Stenting and Restenosis – Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial
Intracoronary Stenting and Restenosis – Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial
In-stent restenosis (ISR) is the leading cause of revascularization failure, occurring in up to 10% of patients within 10&...
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation
Myocardial infarction (MI) remains a leading cause of mortality, and although reperfusion therapy is essential for myocard...
Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction
Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction
Myocardial markers and inflammatory factors have been identified as risk factors for the development of sepsis-induced car...
A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy
A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM), defined as cardiac impairment resulting from the development of diabetes mellitus, has emer...
Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease
Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease
Coronary artery disease (CAD) is increasingly recognized as a chronic inflammatory condition. Interleukin-27 (IL-27), a cy...
Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients
Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients
This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferropt...
Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications
Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications
Cachexia, often seen in chronic heart failure (CHF), worsens patient outcomes and survival. Early detection is crucial, an...
The Proteome Profile of Stress Test Assessed Cardiovascular Disease Risk-Prone Diabetic Subjects
The Proteome Profile of Stress Test Assessed Cardiovascular Disease Risk-Prone Diabetic Subjects
Cardiovascular disease (CVD) is the leading cause of death in the diabetic population. There is a need for specific predic...
Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin
Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin
We tested whether platelet microRNAs (miRs) expression can predict bleeding in patients supported with the HeartMate3 (HM3...
Metabolomic Profiling for Predicting Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease- An Exploratory Study
Metabolomic Profiling for Predicting Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease- An Exploratory Study
We investigated the metabolomic profile of Kawasaki disease(KD) and its association with the development of coronary arter...
Nanoparticles For Rescue: Innovative Therapeutic Strategy For Cardiac Repair After Myocardial Infarction
Nanoparticles For Rescue: Innovative Therapeutic Strategy For Cardiac Repair After Myocardial Infarction
Myocardial infarction (MI), is a leading cause of global mortality, marked by cardiomyocyte death. This takes place as a r...
Normoxemic Extracorporeal Membrane Oxygenation Reduces Infarct Size and Preserves Mitochondrial Integrity in Preclinical Models of Acute Myocardial Infarction
Normoxemic Extracorporeal Membrane Oxygenation Reduces Infarct Size and Preserves Mitochondrial Integrity in Preclinical Models of Acute Myocardial Infarction
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides cardiopulmonary support during the critical care. Des...
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