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COVID‐19 vaccination, time for a second breath?
COVID‐19 vaccination, time for a second breath?
One year into the Covid-19 vaccination campaign, C. Gerke, B. Pulverer and P. Sansonetti discuss its results and redefine ...
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression
Abstract Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is ...
Ketone body oxidation increases cardiac endothelial cell proliferation
Ketone body oxidation increases cardiac endothelial cell proliferation
Abstract Blood vessel formation is dependent on metabolic adaption in endothelial cells. Glucose and fatty acids are essen...
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis
Abstract We report a medium-throughput drug-screening platform (METPlatform) based on organotypic cultures that allows to ...
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS
Abstract Autoinflammatory diseases are a heterogenous group of disorders defined by fever and systemic inflammation sugges...
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma
Abstract Lineage dedifferentiation toward a mesenchymal-like state displaying myofibroblast and fibrotic features is a com...
Seasonality of influenza and other respiratory viruses
Seasonality of influenza and other respiratory viruses
In virology, the term seasonality describes variations in virus prevalence at more or less regular intervals throughout th...
Antifibrotic drugs as therapeutic tools in resistant melanoma
Antifibrotic drugs as therapeutic tools in resistant melanoma
Melanoma is the most aggressive form of skin cancer. Together with the recent advances in immunotherapy, targeted therapy ...
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant
Abstract The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has altered the trajectory...
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems
Abstract Despite the advance and success of precision oncology in gastrointestinal cancers, the frequency of molecular-inf...
Can THEM6 targeting stop resistance to prostate cancer treatment?
Can THEM6 targeting stop resistance to prostate cancer treatment?
Prostate cancer (PCa) clinical management relies heavily on androgen-deprivation therapy (ADT). However, despite experienc...
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours
Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to...
SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance
SARS‐CoV‐2 Omicron emergence urges for reinforced One‐Health surveillance
SARS-CoV-2 Omicron harbors substitutions in the receptor binding domain of the spike which strongly suggest its capacity t...
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection
Abstract The SARS-CoV-2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as ...
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy
Abstract Entering a drug-tolerant persister (DTP) state of cancer cells is a transient self-adaptive mechanism by which a ...
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
Abstract Multiple myeloma (MM) is an incurable malignancy characterized by the uncontrolled expansion of plasma cells in t...
Dual IRE1 RNase functions dictate glioblastoma development
Dual IRE1 RNase functions dictate glioblastoma development
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
Abstract Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prosta...
Decreased memory B cells frequencies in COVID‐19 Delta variant vaccine breakthrough infection
Decreased memory B cells frequencies in COVID‐19 Delta variant vaccine breakthrough infection
Abstract The SARS-CoV-2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as ...
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture
Abstract The prevalence of intracranial aneurysm (IA) is increasing, and the consequences of its rupture are severe. This ...
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma
Abstract Resistance to BRAF/MEK inhibitor therapy in BRAFV600-mutated advanced melanoma remains a major obstacle that limi...
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis
Abstract Psoriasis is a complex chronic inflammatory skin disease with unclear molecular mechanisms. We found that the Src...
Shiga toxin (Stx) type 2‐induced increase in O‐linked N‐acetyl glucosamine protein modification: a new therapeutic target?
Shiga toxin (Stx) type 2‐induced increase in O‐linked N‐acetyl glucosamine protein modification: a new therapeutic target?
Shiga toxin (Stx)-producing Escherichia coli (STEC) causes bloody diarrhea, which may progress to the potentially fatal he...
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential
Abstract The development of eukaryote-derived antimicrobial peptides as systemically administered drugs has proven a chall...
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect
A spectre is haunting biomedical research: It appears that a substantial fraction of published research results cannot be ...
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule
Abstract Epidemiological and clinical observations have shown that potassium ingestion is inversely correlated with arteri...
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical res...
Mining the bacterial genome to discover new antimicrobial molecules
Mining the bacterial genome to discover new antimicrobial molecules
Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organiz...
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer
Abstract Impressive clinical benefit is seen in clinic with PD-1 inhibitors on portion of cancer patients. Yet, there rema...
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