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Intranasal and intramuscular H5-Matrix-M nanoparticle vaccines protects against highly pathogenic H5N1 influenza virus in mice
The emergence of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in dairy cows and transmission to humans has height...
Safety and immunogenicity testing of a melioidosis subunit vaccine candidate in cynomolgus macaques
Burkholderia pseudomallei, the etiologic agent of melioidosis, is a Gram-negative bacterial pathogen that causes severe di...
Optimization of heroin conjugate vaccine performance in rodent models
Opioid use disorder (OUD) remains a global public health concern, exerting a significant economic burden on societies worl...
A19Δbpe275 emerges as a safer live attenuated vaccine candidate
Brucellosis remains a major global challenge to both animal production and public health. Brucella abortus A19, are limite...
Single-cell technologies in mRNA cancer vaccines
The fast evolution of mRNA-based cancer therapeutics requires advanced frameworks to overcome the challenges of tumor hete...
Multiorgan Outcomes Following BNT162b2 mRNA Vaccination vs SARS-CoV-2 Infection: A 30-Million-Person Real-World Cohort Analysis
SARS-CoV-2 infection and BNT162b2 mRNA vaccination carry distinct cardiovascular risk profiles, yet direct comparative evi...
Preserved SARS-CoV-2 T-cell responses despite impaired humoral immunity in children with profound B-cell lymphopenia
Defining vaccine-induced protection in children with humoral immunodeficiency is essential to guide SARS-CoV-2 vaccination...
Fraction of viable virus particles in live varicella vaccine influences the profile of immune response
Compared with inactivated vaccines, live attenuated vaccines can theoretically induce potent cellular and humoral response...
Multi-disciplinary approaches paving the way for clinically effective peptide vaccines for cancer
Multi-disciplinary approaches paving the way for clinically effective peptide vaccines for cancer
Cytotoxic CD8+ T lymphocyte (CTL) cells are central in mediating antitumor immunity. Induction of a robust CTL response re...
A systems biology approach to define SARS-CoV-2 correlates of protection
A systems biology approach to define SARS-CoV-2 correlates of protection
Correlates of protection (CoPs) for SARS-CoV-2 have yet to be sufficiently defined. This study uses the machine learning p...
GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth
GMMA decorated with mucin 1 Tn/STn mimetics elicit specific antibodies response and inhibit tumor growth
Carbohydrate-based therapeutic vaccines are actively pursued as targeted immunotherapy to treat cancer. Aberrant glycosyla...
Risk analysis for outpatient experimental infection as a pathway for affordable RSV vaccine development
Risk analysis for outpatient experimental infection as a pathway for affordable RSV vaccine development
Controlled human infection models (CHIMs) are an important tool for accelerating clinical development of vaccines. CHIM co...
Emulsion adjuvant-induced uric acid release modulates optimal immunogenicity by targeting dendritic cells and B cells
Emulsion adjuvant-induced uric acid release modulates optimal immunogenicity by targeting dendritic cells and B cells
Squalene-based emulsion (SE) adjuvants like MF59 and AS03 are used in protein subunit vaccines against influenza virus (e....
Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4
Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4
Ionizable lipid nanoparticles (LNP) that have enabled the success of messenger RNA (mRNA) vaccines have been shown to be i...
Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens
Bivalent mRNA booster vaccination recalls cellular and antibody immunity against antigenically divergent SARS-CoV-2 spike antigens
The ongoing rollout of SARS-CoV-2 vaccines lags behind rapid viral evolution. Updated vaccine immunogens elicit neutralisi...
Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants
Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants
The effectiveness of intramuscular vaccines aimed at preventing severe COVID-19 remains limited due to waning immunity and...
Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budge...
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulati...
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of ...
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can i...
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bn...
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date ha...
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circula...
Outlook of pandemic preparedness in a post-COVID-19 world
Outlook of pandemic preparedness in a post-COVID-19 world
The COVID-19 pandemic was met with rapid, unprecedented global collaboration and action. Even still, the public health, so...
Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats
Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats
With the large-scale vaccination of lipid nanoparticles (LNP)-based COVID-19 mRNA vaccines, elucidating the potential poly...
Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Rift Valley fever (RVF) is a zoonotic viral disease transmitted by mosquitoes and causes abortion storms, fetal malformati...
Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity...
Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine
Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine
The flavivirus envelope protein is a class II fusion protein that drives flavivirus-cell membrane fusion. The membrane fus...
IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
The inability of neonates to develop CD4+FoxP3-CXCR5hiPD-1hi T follicular helper (TFH) cells contributes to their weak vac...
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