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Adipose-derived mesenchymal stem cell-derived extracellular vesicles reduce glycolysis and polarize macrophages toward M2 phenotype in sepsis-associated acute kidney injury via the miR-574-5p/GLUT1 axis
Adipose-derived mesenchymal stem cell-derived extracellular vesicles reduce glycolysis and polarize macrophages toward M2 phenotype in sepsis-associated acute kidney injury via the miR-574-5p/GLUT1 axis
Extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells (ADSCs) may exert a therapeutic benefit in sepsis...
The interplay between hepatitis B virus and antitumor drugs in the treatment of hepatocellular carcinoma
The interplay between hepatitis B virus and antitumor drugs in the treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) remains a lethal global health burden, with chronic hepatitis B virus (HBV) infection const...
FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer
FLT3LG as an inflammatory hub bridging tumor immune surveillance to therapy response in breast cancer
Breast cancer remains one of the most deadly cancers, highlighting the urgent need for better prognostic markers and treat...
Balancing the scales: folic acid and vitamin B12 in the aggressiveness of hepatocellular carcinoma
Balancing the scales: folic acid and vitamin B12 in the aggressiveness of hepatocellular carcinoma
Hepatocellular carcinoma represents a significant global cancer burden, ranking as the sixth most prevalent malignancy wor...
Targeting SET to counteract Lyn activation demonstrates anti-cancer potential in diffuse large B-cell lymphoma
Targeting SET to counteract Lyn activation demonstrates anti-cancer potential in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is characterized by molecular complexity and heterogeneity. The SET oncoprotein is o...
Integrated bioinformatics analysis reveals novel PANoptosis biomarkers and therapeutic response in clear cell renal cell carcinoma
Integrated bioinformatics analysis reveals novel PANoptosis biomarkers and therapeutic response in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. Apoptosis, pyroptosis, and necroptosis are key reg...
Identification of C1QA as a prognostic marker and regulator of immunosuppressive neutrophils in early-stage lung adenocarcinoma through integrated bioinformatics analyses
Identification of C1QA as a prognostic marker and regulator of immunosuppressive neutrophils in early-stage lung adenocarcinoma through integrated bioinformatics analyses
Neutrophils infiltrate lung tumours and can exhibit an immunosuppressive phenotype that promotes tumour growth, yet their ...
WT1 gene: a potential therapeutic target for multiple cancer treatment strategies
WT1 gene: a potential therapeutic target for multiple cancer treatment strategies
The Wilms’ Tumor 1 (WT1) gene has attracted significant attention in oncological research owing to its involvement i...
Multidimensional analysis reveals the potential of ACSL3 as a cancer biomarker: from pan-cancer exploration to functional validation in hepatocellular carcinoma
Multidimensional analysis reveals the potential of ACSL3 as a cancer biomarker: from pan-cancer exploration to functional validation in hepatocellular carcinoma
ACSL3 converts long-chain fatty acids into acyl-CoA, a key step in lipid metabolism. Since this process is linked to cance...
Angiogenesis and lymphangiogenesis in primary cutaneous lymphomas: a narrative review
Angiogenesis and lymphangiogenesis in primary cutaneous lymphomas: a narrative review
Angiogenesis and lymphangiogenesis are hallmarks of cancer and widely investigated both in solid and hematologic malignanc...
EZH2 suppresses the chemosensitivity of diffuse large B cell lymphoma via regulating TP53INP1
EZH2 suppresses the chemosensitivity of diffuse large B cell lymphoma via regulating TP53INP1
EZH2 functions as an oncogene in various cancers. However, the role of EZH2 in diffuse large B cell lymphoma (DLBCL) is sc...
Identification of potential biomarkers for Lyme disease using bioinformatics and machine learning
Identification of potential biomarkers for Lyme disease using bioinformatics and machine learning
Lyme disease (LD) presents significant diagnostic challenges due to the absence of a reliable screening method for initial...
Research progress of DUB enzyme in breast cancer
Research progress of DUB enzyme in breast cancer
According to GLOBOCAN 2022 cancer incidence and mortality statistics compiled by the International Agency for Research on ...
The MTORC1 signaling pathway related gene POLR3G serves as a potential prognostic biomarker in Hepatocellular Carcinoma
The MTORC1 signaling pathway related gene POLR3G serves as a potential prognostic biomarker in Hepatocellular Carcinoma
This study aims to investigate the prognostic significance and potential biological functions of the MTORC1 signaling path...
Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas
Notch pathway defines an aggressive and immune-suppressive phenotype associated with checkpoint inhibitor resistance in pan-gastrointestinal adenocarcinomas
The Notch pathway regulates the homeostasis and tumorigenesis of gastrointestinal epithelium. Given its roles in cancer st...
The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis
The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis
Ferroptosis is a novel form of cell death induced by ferrous ions and lipid peroxidation. However, the mechanisms of ferro...
miR-3662 targets CAB39L to promote proliferation and invasion in gastric cancer
miR-3662 targets CAB39L to promote proliferation and invasion in gastric cancer
Gastric cancer (GC) represents a highly aggressive malignancy within the gastrointestinal tract. The expression of miR-366...
Reliable biomarkers for diabetic nephropathy using machine learning-assisted contrast-enhanced ultrasonography and clinical characteristics
Reliable biomarkers for diabetic nephropathy using machine learning-assisted contrast-enhanced ultrasonography and clinical characteristics
To utilize machine learning techniques to screen contrast-enhanced ultrasound (CEUS) parameters and clinical characteristi...
Development and evaluation of a nutritional risk prediction model for patients with hepatocellular carcinoma undergoing transarterial chemoembolisation
Development and evaluation of a nutritional risk prediction model for patients with hepatocellular carcinoma undergoing transarterial chemoembolisation
To study the risk factors for malnutrition in patients with hepatocellular carcinoma undergoing transarterial chemoembolis...
VEGF-A in COVID-19: a systematic review and meta-analytical approach to its prognostic value
VEGF-A in COVID-19: a systematic review and meta-analytical approach to its prognostic value
Numerous studies have reported vascular endothelial growth factor A (VEGF-A) has a significant impact on...
Predicting sentinel lymph node metastasis in breast cancer: a study based on the SEER database
Predicting sentinel lymph node metastasis in breast cancer: a study based on the SEER database
Sentinel lymph node biopsy (SLNB), a standard surgical procedure for clinically axillary-negative breast cancer patients, ...
Investigating the pharmacological mechanisms of clopidogrel for carotid stenosis treatment based on network pharmacology and molecular docking techniques
Investigating the pharmacological mechanisms of clopidogrel for carotid stenosis treatment based on network pharmacology and molecular docking techniques
Carotid artery stenosis is a manifestation of atherosclerosis and is associated with an increased risk of various cardiova...
Circulating tumor DNA methylation markers for the early diagnosis of hepatocellular carcinoma
Circulating tumor DNA methylation markers for the early diagnosis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major global health concern, being the sixth most common cancer and the third leading ...
The role of miRNAs in the pathogenesis, diagnosis, and treatment of colorectal cancer and colitis-associated cancer
The role of miRNAs in the pathogenesis, diagnosis, and treatment of colorectal cancer and colitis-associated cancer
MicroRNAs (miRNAs) are a group of noncoding single-stranded RNA biomolecules that act in posttranscriptional regulation of...
Single-center clinical efficacy analysis of 16 cases of primary light chain cardiac amyloidosis including stage IIIb patients
Single-center clinical efficacy analysis of 16 cases of primary light chain cardiac amyloidosis including stage IIIb patients
To investigate the clinical efficacy of daratumumab versus bortezomib in patients with systemic light chain amyloidosis (p...
Analysis of the effectiveness and safety of lenvatinib/bevacizumab combined with PD-1/PD-L1 inhibitors and GEMOX in the first-line treatment of advanced biliary tract carcinoma
Analysis of the effectiveness and safety of lenvatinib/bevacizumab combined with PD-1/PD-L1 inhibitors and GEMOX in the first-line treatment of advanced biliary tract carcinoma
To assess the efficacy and safety of lenvatinib/bevacizumab combined with programmed death-1 (PD-1)/programmed death ligan...
GDF15 activates human fibroblast MRC5 cells via miR-338/STAT1 in silicosis
GDF15 activates human fibroblast MRC5 cells via miR-338/STAT1 in silicosis
Growth differentiation factor 15 (GDF-15) has been implicated in multiple biological functions. However, the role of GDF15...
The necessity of adjuvant chemotherapy in young patients with TNM breast cancer: a population-based study
The necessity of adjuvant chemotherapy in young patients with TNM breast cancer: a population-based study
Chemotherapy clearly adversely affects fertility in women of childbearing age. But it is not yet clear whether chemotherap...
Role of 18F-FDG PET/CT in assessing systemic involvement in ANCA-associated vasculitis
Role of 18F-FDG PET/CT in assessing systemic involvement in ANCA-associated vasculitis
The utilization of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has become a p...
Evaluation of leukemic stem cell (CD26 +) in chronic myeloid leukemia patients with different molecular responses and in treatment-free remission
Evaluation of leukemic stem cell (CD26 +) in chronic myeloid leukemia patients with different molecular responses and in treatment-free remission
CD26 + leukemic stem cells (LSC) are a specific marker for chronic myeloid leukemia (CML), absent in healthy i...
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