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Stress During Lactation: A Hidden Link to Offspring Bone Health
Stress During Lactation: A Hidden Link to Offspring Bone Health
Early-life resource limitation is one factor that could have a major impact on child health and development. Thus, using a...
Patterns of Bone Mineral Density Loss at Multiple Skeletal Sites Following Recent Menopause in Users and Non-Users of Menopausal Hormone Therapy
Patterns of Bone Mineral Density Loss at Multiple Skeletal Sites Following Recent Menopause in Users and Non-Users of Menopausal Hormone Therapy
Post-menopausal bone loss has been well described, however fewer studies have focussed on changes around the time of menop...
Mineral Content and Extracellular Matrix Protein Expression in Mouse Growth Plates During Epiphyseal Fusion: An Observational Study
Mineral Content and Extracellular Matrix Protein Expression in Mouse Growth Plates During Epiphyseal Fusion: An Observational Study
In humans, the growth plate cartilage is completely replaced by bone in late puberty, resulting in epiphyseal fusion. Howe...
Exploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic–Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor
Exploring the Role of FGF7 in Tumor-Induced Osteomalacia. Clinic–Pathologic Analysis in a Patient with a Sino-Nasal Phosphaturic Mesenchymal Tumor
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to the overproduction of Fibroblast Growth Fa...
Lower Limb Bone Mineral Density Reduction is Closely Relative With Diabetic Peripheral Neuropathy in the Postmenopausal Women and Men Over 50 Years Old With T2DM: A cross-Sectional, Controlled Study
Lower Limb Bone Mineral Density Reduction is Closely Relative With Diabetic Peripheral Neuropathy in the Postmenopausal Women and Men Over 50 Years Old With T2DM: A cross-Sectional, Controlled Study
A cross-sectional, controlled study was designed to investigate the relationship between BMD at different sites and DPN in...
Characterization of Bone Matrix Mineralization and Osteocyte Lacunar Density Unveils Microstructural Impairment at the Main Femoral Fracture-Initiating Site in Type 2 Diabetes Mellitus
Characterization of Bone Matrix Mineralization and Osteocyte Lacunar Density Unveils Microstructural Impairment at the Main Femoral Fracture-Initiating Site in Type 2 Diabetes Mellitus
This study aimed to perform microstructural characterization of the increased fragility of human bone in type 2 diabetes m...
Association of the Appendicular Skeletal Muscle Mass-to-Visceral Fat Area Ratio with Cause-Specific Mortality in Diabetes
Association of the Appendicular Skeletal Muscle Mass-to-Visceral Fat Area Ratio with Cause-Specific Mortality in Diabetes
The relationship between muscle mass and visceral fat with mortality risk in diabetes has been extensively studied. This s...
A Systematic Review of the Effects of Bisphosphonates on Osteoblasts In Vitro
A Systematic Review of the Effects of Bisphosphonates on Osteoblasts In Vitro
Bisphosphonates (BPs) are widely used to treat bone disorders, prevent skeletal-related events, and manage bone metastasis...
Bone Mineral Density and Trabecular Bone Score in Children, Adolescents and Young Adults with Familial Dysautonomia
Bone Mineral Density and Trabecular Bone Score in Children, Adolescents and Young Adults with Familial Dysautonomia
Familial dysautonomia (FD) is characterized by skeletal morbidity, including osteoporosis and increased fracture risk. We ...
Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk
Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk
To identify and validate lipid metabolites associated with bone mineral density (BMD) change and fracture risk through int...
Microbes Matter: Exploring the Connection Between Infant Gut Microbiota and Bone Development
Microbes Matter: Exploring the Connection Between Infant Gut Microbiota and Bone Development
Human milk, compared to milk formula, is considered the optimal source of nutrition for infants as it can shape offspring ...
Differential diagnosis of heritable and acquired osteomalacia in children: biochemical and biomaterial signatures
Differential diagnosis of heritable and acquired osteomalacia in children: biochemical and biomaterial signatures
Defective mineralization of bone matrix results in osteomalacia, which universally affects the skeletal system and dentiti...
Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research
Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research
To investigate the feasibility and accuracy of 100 kV low-voltage quantitative CT (QCT) for bone mineral...
Examination of Skeletal and Senescence Phenotypes in Young Mice with Juvenile Onset Type 1 Diabetes
Examination of Skeletal and Senescence Phenotypes in Young Mice with Juvenile Onset Type 1 Diabetes
Type 1 diabetes (T1D) and T2D are associated with skeletal fragility, contributing to increased fracture risk. Whereas dec...
The Influence of Different Degrees of Energy Restriction on Bone Parameters in Young Female Rats
The Influence of Different Degrees of Energy Restriction on Bone Parameters in Young Female Rats
The present study aimed to determine the influence of different degrees of energy restriction (ER) on the bones in young f...
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway
CD8a + GZMK + T Cells Inhibit Osteoclastogenesis in Postmenopausal Osteoporosis via the p38-MAPK Pathway
This study aims to investigate the heterogeneity and function of bone marrow T cells in postmenopausal osteoporosis (PMOP)...
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle
Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle
The systemic administration of cisplatin has been shown to substantially reduce skeletal muscle mass. This is a serious co...
Biochemical Clusters as Substitutes of Bone Biopsies in Kidney Transplant Patients
Biochemical Clusters as Substitutes of Bone Biopsies in Kidney Transplant Patients
Bone and mineral metabolism abnormalities are frequent in kidney transplant recipients and have been associated with cardi...
Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018
Changes in Blood Pressure is Associated with Bone Loss in US Adults: A Cross-Sectional Study from NHANES 2005–2018
Hypertension and osteoporosis are common geriatric diseases, sharing similar risk factors. This study aims to investigate ...
Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family
Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHNNC) is a rare autosomal recessive renal tubulopathy d...
Effect of Roflumilast, a Selective PDE4 Inhibitor, on Bone Phenotypes in ADO2 Mice
Effect of Roflumilast, a Selective PDE4 Inhibitor, on Bone Phenotypes in ADO2 Mice
Autosomal Dominant Osteopetrosis type II (ADO2) is a rare bone disease of impaired osteoclastic bone resorption that usual...
Osteosarcopenia: Prevalence and 10-Year Fracture and Mortality Risk – A Longitudinal, Population-Based Study of 75-Year-Old Women
Osteosarcopenia: Prevalence and 10-Year Fracture and Mortality Risk – A Longitudinal, Population-Based Study of 75-Year-Old Women
Osteosarcopenia is the coexistence of low bone mass and sarcopenia. In older women, its prevalence is not well described, ...
Comparison of the Clinical Outcomes of Vesselplasty vs. Percutaneous Vertebroplasty for the Treatment of Neurologically Intact Osteoporotic Kümmell’s Disease: A Retrospective Study
Comparison of the Clinical Outcomes of Vesselplasty vs. Percutaneous Vertebroplasty for the Treatment of Neurologically Intact Osteoporotic Kümmell’s Disease: A Retrospective Study
Kummell’s disease (KD) is a rare clinical complication of osteoporotic vertebral compression fractures (OVCFs). Mini...
The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study
The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study
Previous epidemiological evidence suggests rheumatoid arthritis is associated with sarcopenia-related features. However, m...
Regulatory Pathways in Growth Plate Chondrocytes that Are Impacted by Matrix Vesicle microRNA Identified by Targeted RISC Pulldown and Sequencing of the Resulting Transcriptome
Regulatory Pathways in Growth Plate Chondrocytes that Are Impacted by Matrix Vesicle microRNA Identified by Targeted RISC Pulldown and Sequencing of the Resulting Transcriptome
During endochondral bone formation, growth plate chondrocytes are differentially regulated by various factors and hormones...
Trend and Seasonality of Hip Fractures in Catalonia, Spain: Exploring the Influence of Climate
Trend and Seasonality of Hip Fractures in Catalonia, Spain: Exploring the Influence of Climate
To describe the secular trend and seasonality of the incidence of hip fracture (HF) and its relationship with climatic var...
Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization
Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization
Observational studies have shown a causal association between dyslipidemia and osteoporosis, but the genetic causation and...
An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
Pathogenic variants disrupting the binding between sclerostin (encoded by SOST) and its receptor LRP4 have previously been...
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization
This study aimed to examine the association between sex hormone-binding globulin (SHBG) and osteoporosis through a cross-s...
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway
In hyperlipidemia-induced osteoporosis, bone marrow mesenchymal stem cells (BMSCs) differentiate into more adipocytes than...
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