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Multi-omics identifies a T2DM-associated immune-regulatory network modulated by electroacupuncture
BackgroundRecent studies suggest a link between immune-related processes and type 2 diabetes (T2DM), yet the specific gene...
Adiposity measured by body roundness index is significantly associated with increased stroke prevalence: a population-based cross-sectional study
BackgroundStroke remains a major cause of disability and death. While central adiposity may contribute to vascular risk, t...
Atherogenic index of plasma and cardiovascular high-risk status in the ChinaHEART luohe cohort: multivariable association modeling with nonlinear dose-response and effect heterogeneity
BackgroundCommunity screening programs increasingly use World Health Organization (WHO) cardiovascular disease (CVD) risk ...
Insulin resistance assessed by estimated glucose disposal rate and risk of coronary artery calcification in middle-aged participants without diabetes undergoing health check-ups
Background and aimsInsulin resistance, assessed by estimated glucose disposal rate (eGDR), is linked to atherosclerosis, y...
Burosumab an emerging therapy in TIO: a local clinical survey and a systematic review with individual patient data analysis
IntroductionBurosumab, a recombinant antibody against fibroblast growth factor 23 (FGF23), is a new therapeutical option f...
Impact of post-vitrification storage duration on clinical outcomes of frozen-thawed cleavage-stage embryos transfer: a propensity score-matched retrospective cohort study
PurposeTo investigate the impact of storage duration after vitrification of cleavage-stage embryos on pregnancy and perina...
Prevalence and characteristics of overweight/obesity in children newly diagnosed with type 1 diabetes in Kuwait
IntroductionThe coexistence of overweight/obesity and type 1 diabetes (T1D) may increase disease burden and management com...
Evolution of molecular diagnostic strategies for 21-hydroxylase deficiency: from classical methods to advanced genomic techniques
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most technically challenging monogenic...
Development of an explainable machine learning model for predicting the occurrence of advanced diabetic kidney disease
AimsThis study aims to develop an interpretable machine learning (ML) model for predicting the occurrence of advanced diab...
Multidisciplinary approach and clinical management of McCune-Albright syndrome
McCune-Albright syndrome (MAS) is a rare, sporadic mosaic disorder classically characterized by fibrous dysplasia (FD) of ...
Association between creatinine-to-body weight ratio and incident prediabetes in Chinese adults: a large-scale retrospective cohort study
Background and objectiveWhile the creatinine-to-body weight ratio (Cre/BW) has emerged as a promising biomarker for muscle...
High hepatic insulin resistance is linked to glucose and lipid profiles in Korean adults with type 2 diabetes
AimsTo characterize the metabolic profiles associated with the Hepatic Insulin Resistance Index (HIRI), in Korean patients...
Oocyte maturation triggering in high responders in IVF treatment: a systematic review and network meta-analysis
ObjectiveThe aim of this study was to compare and rank the efficacy and safety of four final oocyte maturation trigger str...
Maternal obesity alters adipogenic potential and mitochondrial maximal respiration in infant mesenchymal stem cells
ObjectiveTo assess the adipogenic potential and mitochondrial bioenergetics of umbilical cord mesenchymal stem cells (UC-M...
Case Report: Rare collision tumors: ACTH-secreting pituitary neuroendocrine tumor and pituicytoma – histopathological and ultrastructural analysis
Collision tumors are rare conditions characterized by the coexistence of two histologically distinct neoplasms in the same...
The impact of estrogen status on the gut microbiome: a systematic review and meta-analysis
BackgroundEstrogens have been proposed as modulators of gut microbiome (GM) composition, yet evidence from observational s...
Comparing pregnancy outcomes in a population with natural versus surgical reduction of twin pregnancies: a retrospective cohort study
ObjectiveTo compare the cycle of initial twin pregnancy with vanishing twin syndrome (VTS), the cycle of initial twin preg...
Associations of four insulin resistance indicators with subsequent pregnancy outcomes in women with recurrent pregnancy loss
AimsThis study investigated the associations of four insulin resistance (IR) indicators—the triglyceride-glucose (TyG) ind...
Uterine morphology in normogonadotropic anovulation: a comparative study of polycystic ovary syndrome and hypothalamic-pituitary-ovarian dysfunction
PurposeTo compare uterine ultrasound measurements in women with normogonadotropic anovulation, specifically those with pol...
Preconception exposures of female mice to a panel of metabolic disruptors induce sexually dimorphic metabolic perturbations in their offspring
In recent years, there has been a growing emphasis on research investigating the transmission across generations of the ef...
Gender and activity disparities in the relationship between circadian syndrome and gallstone disease
IntroductionGlobally prevalent, gallstone disease (GSD) significantly contributes to hospital admissions for gastrointesti...
Association between night eating frequency and thyroid function and sensitivity: a cross-sectional study from the NHANES database
1 IntroductionThyroglobulin (Tg) is synthesized and stored within the thyroid follicular lumen (1). When the body requires...
Triglyceride-glucose index as a mediator of body mass index and cardiovascular disease in middle-aged and older Chinese adults: a nationally representative longitudinal cohort study
IntroductionThe ongoing challenge of cardiovascular disease (CVD) persists in its impact on global health, affecting both ...
Editorial: Benefits and risks of agonist triggering strategies
Since many years, the GnRH analogues GnRHa and GnRHant are used alternatively for preventing 20 premature LH surge and ovu...
Targeted deletion of the pancreatic β-cell oxytocin receptor and its effects on metabolic regulation and β-cell health
1 IntroductionThe neuropeptide oxytocin (OXT) and its receptor (OXTR) have been shown to play an important role in metabol...
The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China
BackgroundCurrent guidelines define acute decompensated heart failure (ADHF) as the presence of new or worsening symptoms ...
Triglycerides to apolipoprotein A1 ratio: an effective insulin resistance-associated index in identifying metabolic dysfunction-associated fatty liver disease in type 2 diabetes mellitus
IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD) represents a novel classification of nonalcoholic...
Editorial: Endocrine disruptors in obesity
Endocrine disruptors or endocrine disrupting chemicals (EDCs) are natural or man-made chemicals that can be found in vario...
Exploratory miRNA profiling from serum and bone tissue of mice with T1D-induced bone loss
1 IntroductionType 1 diabetes (T1D) is a chronic condition triggered by an autoimmune response that hinders the body’s nat...
Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population
1 IntroductionGestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first reco...
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