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Highlights from SfE BES 2026
This March, more than 1,000 endocrinologists convened in Harrogate, UK, for the annual meeting of the Society for Endocrin...
Clinical obesity in Asian people: bridging the gap between adiposity and disease
Clinical obesity in Asian people: bridging the gap between adiposity and disease
This Perspective argues for a reconceptualization of clinical obesity in Asian populations, moving beyond BMI-centric defi...
Advances in diagnosing and treating diabetic retinopathy
Advances in diagnosing and treating diabetic retinopathy
Diabetic retinopathy has traditionally been defined as a microvascular complication of diabetes mellitus; however, advance...
The pathogenesis and intersecting mechanisms of monogenic bone mass disorders
The pathogenesis and intersecting mechanisms of monogenic bone mass disorders
Monogenic disorders of bone mass arise from variants in single genes disrupting the intricate processes of bone formation ...
Causes and consequences of discontinuation of GLP1RAs or tirzepatide
Causes and consequences of discontinuation of GLP1RAs or tirzepatide
Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists and tirzepatide, a dual GLP1R and glucose-dependent insulinotropi...
Aldosterone synthase inhibitors for the treatment of cardiovascular disease
Aldosterone synthase inhibitors for the treatment of cardiovascular disease
Aldosterone is essential for maintaining blood pressure during hypovolaemia and/or dehydration through genomic actions med...
T cell activity is boosted after meals
T cell activity is boosted after meals
Long-term nutritional status has key roles in supporting immune system function, but how immune cell activity changes duri...
Endocrinologists gather at ECE 2026
In May, >4,500 endocrinologists travelled to Prague, Czechia, (or joined online) for the 28th European Congress of Endo...
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in typ...
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Co...
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH) secretion or action and results in hypocalcaem...
Tryptophan metabolism, exercise and depression
Depression is linked to an altered stress response, as measured by elevated levels of cortisol and systemic inflammation. ...
Recent advances in treatments for congenital adrenal hyperplasia
The first CRFR1 antagonist (crinecerfont) to be used for the treatment of congenital adrenal hyperplasia recently received...
The study that pioneered islet isolation techniques
In rodents, the endocrine pancreas consists of islets of Langerhans scattered throughout the exocrine acinar tissue and ac...
The enduring relevance of the Randle cycle
In people with diabetes mellitus, the heart is metabolically characterized by the excessive use of fatty acids and diminis...
Engineering adipocytes for cancer treatment
Engineering adipocytes for cancer treatment
Tumour cells are well known to have an altered metabolic profile and are more able to obtain and metabolize nutrients than...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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How a common NAFLD genetic risk variant affects human metabolism
How a common NAFLD genetic risk variant affects human metabolism
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A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, drive...
Macrophage and T cell networks in adipose tissue
Macrophage and T cell networks in adipose tissue
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development an...
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