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Digital Immunophenotyping of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Subtypes With Specific Tumor-Immune Microenvironment Features
Digital Immunophenotyping of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Subtypes With Specific Tumor-Immune Microenvironment Features
Atypical carcinoids (ACs) and large cell neuroendocrine carcinomas (LCNECs) are defined by the WHO as intermediate- and hi...
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing
Rb and p53 status helps distinguishing well from poorly differentiated high-grade neuroendocrine neoplasms (HG-NENs) and m...
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy
Alkylating agent-based chemotherapy is one of the main treatment options for patients with metastatic pancreatic neuroendo...
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome
Recent studies have shown that pulmonary neuroendocrine tumor (NET) subgroups, defined by the transcription factors OTP an...
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
About 40% of non-functioning (NF) Pancreatic Neuroendocrine Tumors (PanNETs) harbour mutations in MEN1, often co-occurring...
Follicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology
Follicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology
The diagnosis and prognosis of follicular thyroid neoplasms are based on the identification of capsular and vascular invas...
Correction to: Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Correction to: Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The Utility of Cabozantinib in the Therapy of Endocrine Tumours
The Utility of Cabozantinib in the Therapy of Endocrine Tumours
Endocrine and neuroendocrine malignancies, including epithelial neuroendocrine neoplasms (NENs), phaeochromocytoma/paragan...
Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma
Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy accounting for 1–2% of thyroid carcinomas. As ...
Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance
Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance
Reliable focus is essential for digital cytopathology, yet three-dimensional cell clusters in liquid-based cytology (LBC) ...
Adult Pancreatoblastoma: A Challenge in the Differential Diagnosis of Pancreatic Neuroendocrine Neoplasms
Adult Pancreatoblastoma: A Challenge in the Differential Diagnosis of Pancreatic Neuroendocrine Neoplasms
Authors and AffiliationsDepartment of Biomedical Sciences, Humanitas University, Milan, ItalyVincenzo Guastafierro, Saveri...
Book Review: AFIP Atlases of Tumor and Non-tumor Pathology Series 5, Fascicle 21: Tumors of the Adrenal Glands and Extra-adrenal Paraganglia by Ronald R. de Krijger, Arthur S. Tischler, Sylvia L. Asa, Ernest E. Lack, Marco Volante
Book Review: AFIP Atlases of Tumor and Non-tumor Pathology Series 5, Fascicle 21: Tumors of the Adrenal Glands and Extra-adrenal Paraganglia by Ronald R. de Krijger, Arthur S. Tischler, Sylvia L. Asa, Ernest E. Lack, Marco Volante
Cite this articleMete, O. Book Review: AFIP Atlases of Tumor and Non-tumor Pathology Series 5, Fascicle 21: Tumors of the ...
New Insights from the Expression of the Mismatch Repair System in Pituitary Neuroendocrine Tumors
New Insights from the Expression of the Mismatch Repair System in Pituitary Neuroendocrine Tumors
Although defects in the mismatch repair (MMR) system have been occasionally reported in aggressive/metastatic pituitary ne...
Non-Invasive Follicular Cell-Derived Thyroid Neoplasm Composed Entirely of Spindle Cells Harboring p.Q61R Mutation and Variable Atypia
Non-Invasive Follicular Cell-Derived Thyroid Neoplasm Composed Entirely of Spindle Cells Harboring p.Q61R Mutation and Variable Atypia
Non-Invasive Follicular Cell-Derived Thyroid Neoplasm Composed Entirely of Spindle CellsThe tumor was encapsulated and exh...
The Proteome of Bilateral Macronodular Adrenocortical Disease (BMAD) Shows Different Profiles Correlating with the Genetic Causes and Reveals Specific Dysregulation of RNA Polymerase II and Cholesterol Biosynthesis Enzymes
The Proteome of Bilateral Macronodular Adrenocortical Disease (BMAD) Shows Different Profiles Correlating with the Genetic Causes and Reveals Specific Dysregulation of RNA Polymerase II and Cholesterol Biosynthesis Enzymes
Bilateral macronodular adrenocortical disease (BMAD) is currently described as composed of 4 microscopic subtypes (subtype...
Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) of the Duodenum: An Image in Endocrine Pathology Exploring Patterns of Biomarker Expression in Tumor Elements
Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor (CoGNET) of the Duodenum: An Image in Endocrine Pathology Exploring Patterns of Biomarker Expression in Tumor Elements
Ethics Approval Not required for this article. ...
Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns
Deep Learning Enabled Scoring of Pancreatic Neuroendocrine Tumors Based on Cancer Infiltration Patterns
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of neoplasms that include tumors with different histo...
Clinical Relevance of Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors
Clinical Relevance of Gene Mutations and ALT in Functioning Pancreatic Neuroendocrine Tumors
Functioning pancreatic neuroendocrine tumors (PanNETs) represent a subset of PanNETs that cause symptoms due to hormonal a...
Comprehensive Gene Expression Analysis in Papillary Thyroid Carcinoma Reveals a Transcriptional Profile Associated with Reduced Radioiodine Avidity
Comprehensive Gene Expression Analysis in Papillary Thyroid Carcinoma Reveals a Transcriptional Profile Associated with Reduced Radioiodine Avidity
Papillary thyroid carcinoma (PTC) is the most common form of well-differentiated thyroid cancer (WDTC) and generally has a...
Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: ::, ::, and :: Fusions Induce MAPK Pathway Activation
Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: ::, ::, and :: Fusions Induce MAPK Pathway Activation
Pediatric papillary thyroid carcinoma (PPTC; under age 18 at the time of diagnosis) is relatively uncommon. There are few ...
Methylation Profiles Differ According to Clinical Characteristics in Well-Differentiated Neuroendocrine Tumors of the Lung
Methylation Profiles Differ According to Clinical Characteristics in Well-Differentiated Neuroendocrine Tumors of the Lung
Neuroendocrine tumors (NET) of the lung constitute a rare entity of primary lung malignancies that often exhibit an indole...
Refining Fusion Detection in Papillary Thyroid Carcinoma Through Pan-TRK Immunohistochemistry and Histopathologic Features
Refining Fusion Detection in Papillary Thyroid Carcinoma Through Pan-TRK Immunohistochemistry and Histopathologic Features
NTRK fusions are rare but recurrent driver alterations in papillary thyroid carcinoma (PTC), with therapeutic significance...
Next-Generation Immunohistochemistry in Thyroid Neoplasm: A Practical Review on the Applications in Diagnosis and Molecular Classification
Next-Generation Immunohistochemistry in Thyroid Neoplasm: A Practical Review on the Applications in Diagnosis and Molecular Classification
An integrative histologic and molecular classification of thyroid tumors has become clinically relevant due to the potenti...
DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms
DLL3 Expression in Neuroendocrine Carcinomas and Neuroendocrine Tumours: Insights From a Multicentric Cohort of 1294 Pulmonary and Extrapulmonary Neuroendocrine Neoplasms
Delta-like ligand 3 (DLL3) is frequently expressed in pulmonary small cell neuroendocrine carcinoma (SCNEC) and has emerge...
Impact of Tissue Thickness on Computational Quantification of Features in Whole Slide Images for Diagnostic Pathology
Impact of Tissue Thickness on Computational Quantification of Features in Whole Slide Images for Diagnostic Pathology
Tissue section thickness (TST) is an understudied variable in digital pathology that significantly impacts both visual ass...
Multicentric Retrospective Analysis of Oncocytic Adrenocortical Carcinoma: Insights into Clinical and Management Strategies
Multicentric Retrospective Analysis of Oncocytic Adrenocortical Carcinoma: Insights into Clinical and Management Strategies
Oncocytic adrenocortical carcinoma (OAC) is a rare variant of conventional adrenocortical carcinoma (ACC), characterized b...
Subclassifying "Atypia of Undetermined Significance (AUS)" Category in the 2023 Bethesda System for Thyroid Cytopathology: Analyzing K-TIRADS, V600E Mutation, and Risk of Malignancy
Subclassifying "Atypia of Undetermined Significance (AUS)" Category in the 2023 Bethesda System for Thyroid Cytopathology: Analyzing K-TIRADS, V600E Mutation, and Risk of Malignancy
The 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) update refines the atypia of undetermined significan...
Prevalence and Clinical Impact of p.V600E Mutation in Papillary Thyroid Carcinoma
Prevalence and Clinical Impact of p.V600E Mutation in Papillary Thyroid Carcinoma
Identifying risk factors in papillary thyroid carcinoma (PTC) that warrant more aggressive treatment is paramount. Importa...
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling
Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with a poor prognosis. Despite its rarity, identifying pred...
Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival
Amplification a Risk Stratification Marker in Papillary Thyroid Carcinoma, Significantly Correlated with Tumor Recurrence and Survival
Few studies have analyzed the prevalence of TERT amplification in thyroid cancer, showing discrepancies in various topics....
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