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Thyroid Tumors of Uncertain Malignant Potential (UMP)- Clinicopathologic and Molecular Characterization of 324 Cases
Thyroid Tumors of Uncertain Malignant Potential (UMP)- Clinicopathologic and Molecular Characterization of 324 Cases
Thyroid tumors with questionable capsular invasion (CI) or angioinvasion (AI) pose diagnostic and management challenges. T...
Thyroblastoma Dominated by a Primitive Small Round Cell Component: A Diagnostic Pitfall
Thyroblastoma Dominated by a Primitive Small Round Cell Component: A Diagnostic Pitfall
The tumor was predominantly located within a 2.5 cm sclerotic thyroid nodule, showing capsular invasion and infiltration i...
Clinicopathologic and Molecular Features of Poorly Differentiated Thyroid Carcinomas in Adults ≤ 45 Years of Age
Clinicopathologic and Molecular Features of Poorly Differentiated Thyroid Carcinomas in Adults ≤ 45 Years of Age
The clinical behavior and molecular underpinnings of rare cases of poorly differentiated thyroid carcinoma (PDTC) diagnose...
Lineage Classification of Pituitary Neuroendocrine Tumors From Whole-Slide Images Using Attention-Guided Graph Representation Learning
Lineage Classification of Pituitary Neuroendocrine Tumors From Whole-Slide Images Using Attention-Guided Graph Representation Learning
Pituitary neuroendocrine tumors (PitNETs) are common sellar neoplasms and represent a major component of routine pituitary...
Impact of Molecular Testing on Surgical Decision-Making in Indeterminate Thyroid Nodules: A Global Meta-Analysis Across Test Generations
Impact of Molecular Testing on Surgical Decision-Making in Indeterminate Thyroid Nodules: A Global Meta-Analysis Across Test Generations
Thyroid nodules with indeterminate cytology represent a clinical challenge owing to uncertain malignancy risk, often leadi...
Molecular Profiling of Digestive Grade 3 Neuroendocrine Tumors Reveals a Shared Molecular Framework with Lower-Grade Tumors, Marked Heterogeneity, and Therapeutic Opportunities
Molecular Profiling of Digestive Grade 3 Neuroendocrine Tumors Reveals a Shared Molecular Framework with Lower-Grade Tumors, Marked Heterogeneity, and Therapeutic Opportunities
Well-differentiated neuroendocrine tumors, grade 3 (NETs G3) of the digestive system are high-grade neuroendocrine neoplas...
Three-Tier Prognostic Stratification of Lung Carcinoids (NET G1-G2-G3) by Multivariable, Data-Driven Integration of Ki-67 and Mitotic Count
Three-Tier Prognostic Stratification of Lung Carcinoids (NET G1-G2-G3) by Multivariable, Data-Driven Integration of Ki-67 and Mitotic Count
Pulmonary neuroendocrine tumors (NETs) include typical and atypical carcinoids, corresponding to low- and intermediate-gra...
Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma
Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma
The mechanisms underlying how adrenocortical carcinoma (ACC) progresses into a metastatic and lethal disease remain poorly...
Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis
Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis
Current data on neuroendocrine tumors (NETs) of the gallbladder and cystic duct (GB-NETs) are highly limited, and the avai...
Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical Transcript Architectures in Oncocytic Thyroid Neoplasms
Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical Transcript Architectures in Oncocytic Thyroid Neoplasms
Oncocytic thyroid carcinomas are characterized by a unique chromosomal landscape and frequent resistance to radioactive io...
An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups
An Integrative RNA Spliceosomic Landscape of Pancreatic Neuroendocrine Tumors Identifies Clinically Relevant Molecular Subgroups
Alterations in alternative splicing are emerging as a novel cancer hallmark, offering new insights into tumor biology. How...
Prevalence and Histologic Features of Multifocal Fibrosing Thyroiditis in the Routine Pathology Practice
Prevalence and Histologic Features of Multifocal Fibrosing Thyroiditis in the Routine Pathology Practice
Multifocal fibrosing thyroiditis (MFT) is a poorly understood condition characterized by multiple fibrotic scar-like lesio...
Integrated Pathologic, Genomic, and Transcriptomic Analysis of Renal Neuroendocrine Tumors Reveals Neuroendocrine Transcriptional Programs and Associated Gastrointestinal-Type Epithelium in a Subset of Cases
Integrated Pathologic, Genomic, and Transcriptomic Analysis of Renal Neuroendocrine Tumors Reveals Neuroendocrine Transcriptional Programs and Associated Gastrointestinal-Type Epithelium in a Subset of Cases
Renal well-differentiated neuroendocrine tumors (RenNETs) are rare primary renal neoplasms with enigmatic histogenesis. To...
Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study
Circulating Tumor DNA Analysis in Adrenocortical Carcinoma: A Retrospective Cohort Study
Adrenocortical carcinoma (ACC) is a rare malignancy with high recurrence rates. Circulating tumor DNA (ctDNA) is a minimal...
Expansion of Germline Variants in Primary Hyperparathyroidism: Fumarate Hydratase Deficiency as a Cause of Parathyroid Adenomas
Expansion of Germline Variants in Primary Hyperparathyroidism: Fumarate Hydratase Deficiency as a Cause of Parathyroid Adenomas
A substantial fraction (60–85%) of hereditary primary hyperparathyroidism (hPHPT) lacks an identifiable genetic etio...
A Cauda Equina Neuroendocrine Tumor with Tyrosine Hydroxylase Expression
A Cauda Equina Neuroendocrine Tumor with Tyrosine Hydroxylase Expression
Asa SL, Ezzat S, Mete O (2018) The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations. J Clin Med ...
Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas
Tumor Necrosis is Associated with an Increased Metastatic and Cardiovascular Risk in Paragangliomas: A Single-Center Series and Meta-Analysis Comparing Necrosis and Cystic Degeneration in Paragangliomas
Paragangliomas (PGLs) are rare neural crest–derived tumors with highly variable morphology and clinical behavior. Th...
Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas
Comprehensive Genomic Analysis in Hereditary Adrenal and Extra-Adrenal Paragangliomas
Adrenal and extra-adrenal paragangliomas (PPGLs) are highly heritable non-epithelial neuroendocrine neoplasms. Through a r...
Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System
Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System
Neuroendocrine neoplasms (NENs) of the urinary bladder are rare but highly aggressive tumors that account for under 1% of ...
Real-World-Feasible Immunohistochemistry of ATRX, DAXX, and Menin Identifies a Subgroup of Non-Functioning Pancreatic Neuroendocrine Tumors with low Recurrence Risk to Guide De-Escalating Surveillance
Real-World-Feasible Immunohistochemistry of ATRX, DAXX, and Menin Identifies a Subgroup of Non-Functioning Pancreatic Neuroendocrine Tumors with low Recurrence Risk to Guide De-Escalating Surveillance
Non-functioning pancreatic neuroendocrine tumors (NF-pNETs) show a variable prognosis. Despite 40–60% of patients re...
Digital Immunophenotyping of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Subtypes With Specific Tumor-Immune Microenvironment Features
Digital Immunophenotyping of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Subtypes With Specific Tumor-Immune Microenvironment Features
Atypical carcinoids (ACs) and large cell neuroendocrine carcinomas (LCNECs) are defined by the WHO as intermediate- and hi...
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing
Performance of Immunohistochemistry to Detect Rb/p53 Alterations in High-Grade Neuroendocrine Neoplasms: Staining Patterns and Comparison with Genetic Testing
Rb and p53 status helps distinguishing well from poorly differentiated high-grade neuroendocrine neoplasms (HG-NENs) and m...
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy
Immunotherapy for Metastatic Pancreatic Neuroendocrine Tumors with High Mutational Burden and Mismatch Repair Alterations Following Treatment with Alkylating Chemotherapy
Alkylating agent-based chemotherapy is one of the main treatment options for patients with metastatic pancreatic neuroendo...
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome
Phenotypic Landscape of Pulmonary Neuroendocrine Tumors: Subtyped by OTP/ASCL1 Expression Correlated with Histology, Hormones and Outcome
Recent studies have shown that pulmonary neuroendocrine tumor (NET) subgroups, defined by the transcription factors OTP an...
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
About 40% of non-functioning (NF) Pancreatic Neuroendocrine Tumors (PanNETs) harbour mutations in MEN1, often co-occurring...
Follicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology
Follicular Thyroid Carcinoma Relapse Cases - Revisited by X-ray 3D Virtual Histology
The diagnosis and prognosis of follicular thyroid neoplasms are based on the identification of capsular and vascular invas...
Correction to: Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Correction to: Molecular Subtypes of Pancreatic Neuroendocrine Tumors Mutated in Explain Biological Variability
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
The Utility of Cabozantinib in the Therapy of Endocrine Tumours
The Utility of Cabozantinib in the Therapy of Endocrine Tumours
Endocrine and neuroendocrine malignancies, including epithelial neuroendocrine neoplasms (NENs), phaeochromocytoma/paragan...
Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma
Multi-center Assessment of DLL3 Expression by Immunohistochemistry in Medullary Thyroid Carcinoma
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy accounting for 1–2% of thyroid carcinomas. As ...
Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance
Quantitative Assessment of Focus Quality in Whole-Slide Imaging of Thyroid Liquid-Based Cytology Using Laplacian Variance
Reliable focus is essential for digital cytopathology, yet three-dimensional cell clusters in liquid-based cytology (LBC) ...
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