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Metabolic dysregulation in psychotic mania: longitudinal cardiometabolic changes with exploratory analyses of serum uric acid
Metabolic dysregulation in psychotic mania: longitudinal cardiometabolic changes with exploratory analyses of serum uric acid
Psychotic mania, a severe form of bipolar disorder, presents with elevated mood, hyperactivity, and psychotic symptoms. It...
Role of insulin-like growth factor-1/2 and related signaling in parkinson’s disease
Role of insulin-like growth factor-1/2 and related signaling in parkinson’s disease
Parkinson’s disease (PD) is a chronically progressive neurodegenerative disorder primarily characterized by the dege...
reduces D-galactose-induced hepatic and cerebral oxidative damage in aging mice via the Nrf2/ARE pathway
reduces D-galactose-induced hepatic and cerebral oxidative damage in aging mice via the Nrf2/ARE pathway
The global aging population necessitates safe, multi-target strategies to combat age-related functional decline. Tu-Si-Zi-...
Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets
Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets
Tryptophan (TRP) is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metaboli...
Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer’s disease: a study combining network pharmacology, transcriptomics, and experimental validation
Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer’s disease: a study combining network pharmacology, transcriptomics, and experimental validation
Ferroptosis is considered to be an important pathological driver of Alzheimer’s disease (AD), and inhibiting neurona...
Neuroinflammatory profiles and cellular localization of TNF-α associated with chronic vanadium neurotoxicity
Neuroinflammatory profiles and cellular localization of TNF-α associated with chronic vanadium neurotoxicity
Vanadium, an environmental pollutant, is closely associated with neurodegeneration, primarily through oxidative damage and...
Emerging neurological and cognitive symptoms in patients with late-onset ornithine transcarbamylase deficiency: a narrative review
Emerging neurological and cognitive symptoms in patients with late-onset ornithine transcarbamylase deficiency: a narrative review
Ornithine transcarbamylase deficiency (OTCD) is a rare X-linked urea cycle disorder associated with mild-to-severe neurolo...
Sex-dependent behavioral and hypothalamic receptor changes after early-life monosodium glutamate (MSG) exposure and adult social stress in Wistar rats
Sex-dependent behavioral and hypothalamic receptor changes after early-life monosodium glutamate (MSG) exposure and adult social stress in Wistar rats
Obesity is a growing public health issue, with comorbidities including metabolic syndrome and psychiatric disorders. Stres...
Ellagic acid can improve stroke by regulating gut microbiota
Ellagic acid can improve stroke by regulating gut microbiota
Stroke is a condition characterized by high rates of morbidity, mortality, and disability. Developing new and effective tr...
Plasma sterol profiling in autism spectrum disorder: insights from cerebrotendinous xanthomatosis screening and beyond
Plasma sterol profiling in autism spectrum disorder: insights from cerebrotendinous xanthomatosis screening and beyond
Cerebrotendinous xanthomatosis (CTX) is a rare, treatable bile acid synthesis disorder characterized by increased levels o...
Vitamin D and hypoxia-inducible factors signaling interplay: A hypothesis-driven review of therapeutic strategies for acute cerebral infarction
Vitamin D and hypoxia-inducible factors signaling interplay: A hypothesis-driven review of therapeutic strategies for acute cerebral infarction
Acute cerebral infarction (ACI) is a severe cerebrovascular disease characterized by a steadily rising global incidence ra...
From bench to bedside: Emerging therapeutics for alzheimer's disease in clinical trials
From bench to bedside: Emerging therapeutics for alzheimer's disease in clinical trials
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive declination, neuronal loss, &am...
Circadian disruption as a driver and target in neurodegenerative diseases: from molecular mechanisms to chronotherapeutic strategies
Circadian disruption as a driver and target in neurodegenerative diseases: from molecular mechanisms to chronotherapeutic strategies
The Circadian System is a complex network of coordinated clocks that regulates the organism’s internal clock in sync...
Targeting of neuroinflammation, oxidative stress, and synaptic dysfunction by vinpocetine in alzheimer’s disease: a comprehensive appraisal
Targeting of neuroinflammation, oxidative stress, and synaptic dysfunction by vinpocetine in alzheimer’s disease: a comprehensive appraisal
Alzheimer disease (AD) is a neurodegenerative disease presented with progressive memory loss and cognitive impairment. Dep...
The metabolic roots of memory loss: interlinking the Diabetes-Alzheimer’s hypothesis
The metabolic roots of memory loss: interlinking the Diabetes-Alzheimer’s hypothesis
Diabetes mellitus (DM) and Alzheimer’s disease (AD) are two of the most widely recognized as prevalent conditions af...
Activation of mitophagy via miR-223/NLRP3 axis ameliorates dopaminergic neuronal damage in parkinson’s disease
Activation of mitophagy via miR-223/NLRP3 axis ameliorates dopaminergic neuronal damage in parkinson’s disease
Parkinson’s disease (PD) is a major neurodegenerative disorder. MiR-223 as a potential biomarker for Parkinson’...
Neuroprotective effects of nano-phytosomes in haloperidol-induced Parkinson’s rat model: A computational-guided Olivil nanoformulation delivery approach
Neuroprotective effects of nano-phytosomes in haloperidol-induced Parkinson’s rat model: A computational-guided Olivil nanoformulation delivery approach
Parkinson’s disease (PD) is an age-associated neurodegenerative disorder. While allopathic treatments offer symptoma...
Metabolomic analysis of blood spots in a Chinese cohort with autism spectrum disorders: a pilot study
Metabolomic analysis of blood spots in a Chinese cohort with autism spectrum disorders: a pilot study
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic component that is becoming increasin...
Differential effects of industrial and ruminant trans fatty acids on appetitive memory
Differential effects of industrial and ruminant trans fatty acids on appetitive memory
Trans-fatty acids (TFAs) are categorized into industrial TFAs (iTFAs) and ruminant TFAs (rTFAs). TFAs intakes over 48&...
An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer’s disease in rats
An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer’s disease in rats
The choroid plexus (CP), which is responsible for forming the blood-cerebrospinal fluid barrier, contributes to the modula...
Ivermectin’s neuroprotective effects decrease with prolonged use after cerebral ischemia/reperfusion
Ivermectin’s neuroprotective effects decrease with prolonged use after cerebral ischemia/reperfusion
Ivermectin (IVM), the recipient of the 2015 Nobel Prize, is an FDA-approved drug for a variety of parasitic diseases in an...
Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery
Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery
Traumatic brain injury (TBI) is defined as structural damage or physiological disruption of brain function resulting from ...
Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury
Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury
This study investigates the specific mechanisms by which SIRT1/SIRT3 modulates the reduction of mitochondrial regeneration...
Neuroprotective efficacy of in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems
Neuroprotective efficacy of in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems
The incidence of neurotoxicity has been rising recently due to increase exposure to toxic compounds such as Cadmium (Cd). ...
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression
To investigate the mechanisms by which butylphthalide (NBP) alleviates cerebral edema after intracerebral hemorrhage (ICH)...
Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice
Neuroprotective effects of Simvastatin against alcohol-induced oxidative stress and neurodegeneration in the Hippocampus of adolescent mice
Adolescent alcohol abuse in disadvantaged communities is a significant concern due to regulatory gaps. It disrupts brain d...
From nonalcoholic fatty liver disease to neuroinflammation: the role of chronic systemic inflammation
From nonalcoholic fatty liver disease to neuroinflammation: the role of chronic systemic inflammation
Neuroinflammation is a significant contributor to neurological disorders. While previous research has mainly concentrated ...
Paeoniflorin and depression: a comprehensive review of underlying molecular mechanisms
Paeoniflorin and depression: a comprehensive review of underlying molecular mechanisms
Depression is one of the common mental disorders that often leads to persistent low mood, feelings of sadness or a sense o...
Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD)
Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD)
Diabetes patients have reduced basal cognitive abilities like learning, memory, and perceptual quickness, as well as a 65 ...
Optimizing predictive biomarkers for alzheimer’s disease: muscarinic M1 antagonist-induced synaptic signaling disruptions and bee venom intervention through cholinergic modulation and multiregression dose selection
Optimizing predictive biomarkers for alzheimer’s disease: muscarinic M1 antagonist-induced synaptic signaling disruptions and bee venom intervention through cholinergic modulation and multiregression dose selection
Alzheimer’s (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neurochemical im...
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