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Response to Comment on Ipp and Kumar. A Clinical Conundrum: Intensifying Glucose Control in the Presence of Advanced Diabetic Retinopathy. Diabetes Care 2021;44:2192–2193
Rigalleau et al. (1) provide interesting findings from their observational follow-up study of long-term sequelae of type 2...
The Brains Behind SGLT2 Inhibition
Control of the central nervous regulation of eating behavior and further body functions by administration of drugs is a lo...
Risk of Foot Ulcer and Lower-Extremity Amputation Among Participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
OBJECTIVE. Intensive glycemic control reduces the risk of kidney, retinal, and neurologic complications in type 1 diabetes...
ADA/EASD Precision Medicine in Diabetes Initiative: An International Perspective and Future Vision for Precision Medicine in Diabetes
The Precision Medicine in Diabetes Initiative (PMDI) was launched in 2018 by the American Diabetes Association (ADA) in co...
Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation
OBJECTIVE. Total pancreatectomy with islet autotransplantation (TPIAT) is indicated to alleviate debilitating pancreas-rel...
Trends in Glycemic Control Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study
OBJECTIVE. To describe temporal trends and correlates of glycemic control in youth and young adults (YYA) with youth-onset...
Comment on Lee et al. Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study. Diabetes Care 2021;44:2419–2426
We read with great interest the article by Lee et al. (1) showing an increased risk of retinal vein occlusion (RVO) among ...
Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826–1834
We read with interest the letter and study synopsis from Ivanisevic and Djelmis (1) and published descriptions (n = ∼30) o...
Comment on Ipp and Kumar. A Clinical Conundrum: Intensifying Glucose Control in the Presence of Advanced Diabetic Retinopathy. Diabetes Care 2021;44:2192–2193
We were interested by the recent article from Ipp and Kumar (1), who questioned whether we should slow down glycemic norma...
Response to Comment on Lee et al. Sodium–Glucose Cotransporter 2 Inhibitors and Risk of Retinal Vein Occlusion Among Patients With Type 2 Diabetes: A Propensity Score–Matched Cohort Study. Diabetes Care 2021; 44:2419–2426
We would like to thank Feldman-Billard and Paques (1) for their interest in our article (2) and for expressing their conce...
Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826–1834
We read with interest the article by Meek et al. (1). The authors have measured maternal serum C-peptide concentrations at...
2022 National Standards for Diabetes Self-Management Education and Support
By the most recent estimates, 34.2 million people in the U.S. have diabetes (1). At the same time, 88 million people are a...
Controversies Around the Measurement of Blood Ketones to Diagnose and Manage Diabetic Ketoacidosis
The measurement of blood ketones in preference to urine ketones has become a well-established tool in the diagnosis and ma...
Structural Lesions on Kidney Biopsy in Youth-Onset and Adult-Onset Type 2 Diabetes
OBJECTIVE. Type 2 diabetes (T2D) is a leading cause of end-stage kidney disease worldwide. Recent studies suggest a more a...
Utilization Rates of SGLT2 Inhibitors and GLP-1 Receptor Agonists and Their Facility-Level Variation Among Patients With Atherosclerotic Cardiovascular Disease and Type 2 Diabetes: Insights From the Department of Veterans Affairs
OBJECTIVE. There is mounting evidence regarding the cardiovascular benefits of sodium–glucose cotransporter 2 inhibitors (...
Socioeconomic Factors Play a More Important Role than Clinical Needs in the Use of SGLT2 Inhibitors and GLP-1 Receptor Agonists in People With Type 2 Diabetes
Growing evidence from clinical trials and observational studies has demonstrated cardiac and renal benefits of two newer g...
Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study
OBJECTIVE. Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whe...
GLP-1 Receptor Agonists for Cardiovascular Protection: A Matter of Time
Efpeglenatide is a newly developed exendin-derived long-acting glucagon-like peptide 1 receptor agonist (GLP-1RA). It is c...
Effect of Dapagliflozin on Hematocrit in Patients With Type 2 Diabetes at High Cardiovascular Risk: Observations From DECLARE-TIMI 58
There is a growing body of evidence for sodium–glucose cotransporter 2 (SGLT2) inhibitors, supporting their use in a wide ...
Factors Associated With Discontinuation of Subspecialty Diabetes Care During the COVID-19 Pandemic: A Multisite Retrospective Cohort Study
Subspecialty care for people with diabetes (PWD) changed dramatically in 2020, with rapid conversion to telehealth necessi...
Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol
OBJECTIVE. LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to...
A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes
OBJECTIVE. To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), mode...
Impact of a Novel Diabetes Support System on a Cohort of Individuals With Type 1 Diabetes Treated With Multiple Daily Injections: A Multicenter Randomized Study
OBJECTIVE. Achieving optimal glycemic control for many individuals with type 1 diabetes (T1D) remains challenging, even wi...
Durability of High-Frequency 10-kHz Spinal Cord Stimulation for Patients With Painful Diabetic Neuropathy Refractory to Conventional Treatments: 12-Month Results From a Randomized Controlled Trial
Diabetic sensorimotor peripheral neuropathy is the most common complication of diabetes and results in potentially debilit...
Response to Comment on Liu et al. Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017. Diabetes Care 2021;44:2503–2509
We thank Weng et al. (1) for their interest in our article regarding the incidence of type 1 diabetes (T1D) in the Chinese...
Effect of Fenofibrate Therapy on Laser Treatment for Diabetic Retinopathy: A Meta-Analysis of Randomized Controlled Trials
Diabetic eye disease (retinopathy and maculopathy) remains a leading cause of blindness and impaired vision, and it is als...
Glycemic Control and Risk of Sepsis and Subsequent Mortality in Type 2 Diabetes
OBJECTIVE. To investigate the nature of the relationship between HbA1c and sepsis among individuals with type 2 diabetes, ...
Weighing in on Type 2 Diabetes Remission
Type 2 diabetes (T2D) is a growing public health challenge that affects 422 million people and increases morbidity and mor...
Comment on Shih et al. Increased Incidence of Pediatric Type 1 Diabetes With Novel Association With Coxsackievirus A Species in Young Children but Declined Incidence in Adolescents in Taiwan. Diabetes Care 2021;44:1579–1585
We applaud Shih et al. (1) for using enterovirus (EV) infection as a time-dependent covariate and time to type 1 diabetes ...
Response to Comment on Shih et al. Increased Incidence of Pediatric Type 1 Diabetes With Novel Association With Coxsackievirus A Species in Young Children but Declined Incidence in Adolescents in Taiwan. Diabetes Care 2021;44:1579–1585
We appreciate the comments from Dr. Yen and Dr. Wei (1). Here is our response to their concerns. First, we agree that the ...
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