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Revisited case for intranasal neuropeptide Y based therapeutics: From preclinical to clinical

Compelling evidence from a variety of approaches attributes manifold benefits to NPY in the brain. NPY can reduce stress, ...

Neuropeptides

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Somatostatin neurons of the bed nucleus of the Stria terminalis drive aversive behaviors in mice

Available online 6 March 2026, 102607Author links open overlay panel, , , , , , , AbstractAppropriate valence processing, ...

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Neuropeptide systems in temporal lobe epilepsy

Neuropeptides are commonly co-expressed with classical neurotransmitters such as glutamate, GABA, or serotonin within the ...

Neuropeptides

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The role of galanin/GALR2 signaling in the link between type 2 diabetes and Alzheimer's disease

In recent decades incidences of Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are rapidly increasing, becom...

Neuropeptides

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Targeting the brain through the nose: Advances in polymeric nanoparticle delivery for schizophrenia

“Schizophrenia is a chronic and complex psychiatric disorder characterized by profound disturbances in perception, cogniti...

Neuropeptides

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Oxytocin as a neurotherapeutic target for nicotine withdrawal and craving modulation

Nicotine addiction remains one of the most persistent and challenging forms of substance dependence worldwide. Despite dec...

Neuropeptides

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Oxytocin beyond social bonding: Advancing neuromodulation, synaptic plasticity, and epigenetic precision in CNS disorders

Neurodegenerative diseases are characterized by the gradual loss of neurons, often leading to death (Khan et al., 2025). T...

Neuropeptides

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Differential effects of orexin system activation on dizocilpine-induced schizophrenia-like behaviors in mice

Schizophrenia encompasses positive, negative, and cognitive symptoms, and accumulating evidence suggests that the orexin s...

Neuropeptides

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The phoenixin-14/GPR173 Axis enhances post-stroke angiogenesis through ETS1-mediated VEGF signaling

Intracerebral hemorrhage (ICH) is a devastating stroke subtype that accounts for 10–20% of strokes worldwide (Aronowski an...

Neuropeptides

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Netrin-3 rectifies diabetes-induced cognitive impairment by counteracting hippocampal oxidative stress and NLRP3 inflammasome activation

Type 2 diabetes represents a mounting global health challenge, with its impact extending beyond traditional complications ...

Neuropeptides

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Effects of oxytocin on behavior and neurotrophic factors in the brain of aged female rats exposed to chronic social isolation

Social isolation refers to a state in which an individual's interaction with their environment is minimized. Chronic socia...

Neuropeptides

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Rapamycin reveals neuropeptide Y as a regulator of senescence and inflammatory pathways in arthritis

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by destructive and debilitating arthritis. Its pat...

Neuropeptides

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Neuroprotective effect of Ac-SDKP peptide in SH-SY5Y cells and rat model of Parkinson's disease against 6-OHDA-induced oxidative stress and ER stress

Parkinson's disease (PD) represents a progressive neurological condition marked by two hallmark pathological features: the...

Neuropeptides

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Dynorphin B induces mitochondrial fragmentation in NSCLC through the PKD/DRP-1 signaling pathway

Lung cancer persists in being the predominant contributing factor contributing to illness and death attributed to cancer w...

Neuropeptides

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Tauopathies: Emerging discoveries on tau protein, with a special focus on Alzheimer's disease

‘Tauopathies’ is a term used to describe the neurodegenerative diseases (NDDs) caused by abnormal accumulation of misfolde...

Neuropeptides

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Neuropeptide Y as a multifaceted modulator of neuroplasticity, Neuroinflammation, and HPA axis dysregulation: Perceptions into treatment-resistant depression

Treatment-resistant depression (TRD) poses a significant challenge within the field of mental health (McIntyre et al., 202...

Neuropeptides

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Irisin alleviates anxiety and deficits in fear extinction in PTSD within SPS mouse model

Post-traumatic stress disorder (PTSD) is a common psychological condition characterized by delayed and persistent mental d...

Neuropeptides

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Interplay of neuropeptide Y and autophagy in Alzheimer's disease: Therapeutic perspectives and mechanistic insights

Alzheimer's disease (AD) is a chronic neurodegenerative condition and the most common cause of dementia worldwide, affecti...

Neuropeptides

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Upregulation of Xbp1 in NPY/AgRP neurons reverses diet-induced obesity and ameliorates leptin and insulin resistance