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FSH Signaling in Osteoporosis and Alzheimer’s Disease
FSH Signaling in Osteoporosis and Alzheimer’s Disease
The female sex is itself a major risk factor for both osteoporosis and Alzheimer’s disease (AD), two age–relat...
The PTSD-Bone Axis: Evidence, Mechanisms, and Management
The PTSD-Bone Axis: Evidence, Mechanisms, and Management
This review explores the relationship between post-traumatic stress disorder (PTSD) and bone health, focusing on how chron...
Advances in Imaging-Based Fracture Risk Assessment for Unlocking Latent Skeletal Fragility
Advances in Imaging-Based Fracture Risk Assessment for Unlocking Latent Skeletal Fragility
This review summarizes recent advancements in imaging-based fracture risk assessment utilizing routinely acquired clinical...
Interferon–JAK–STAT Axis in Bone Metabolism
Interferon–JAK–STAT Axis in Bone Metabolism
Emerging evidence indicates that interferons (IFNs) are crucial links between immune activation and skeletal remodeling, h...
Health-related Quality of Life After Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures
Health-related Quality of Life After Vertebral Augmentation for Osteoporotic Vertebral Compression Fractures
Health-related quality of life (HRQOL) in patients with osteoporotic vertebral compression fractures (OVCFs) varies signif...
PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly
PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly
While GWAS has identified many loci associated with bone mineral density (BMD), translating these findings into functional...
The Use of Statistical Shape and Appearance Modelling for Predicting Osteoporotic Fracture Risk
The Use of Statistical Shape and Appearance Modelling for Predicting Osteoporotic Fracture Risk
Osteoporotic fractures remain a major cause of morbidity and mortality worldwide. Current clinical assessment metrics (e.g...
Sequential Versus Step-Therapy Approaches for Osteoporosis Management in Orthopedic Subspecialties
Sequential Versus Step-Therapy Approaches for Osteoporosis Management in Orthopedic Subspecialties
Osteoporosis affects more than 53 million Americans and contributes to nearly 2 million fragility fractu...
Brain–bone Crosstalk after Neurotrauma: Dual Effects of Traumatic Brain Injury on Skeletal Remodeling
Brain–bone Crosstalk after Neurotrauma: Dual Effects of Traumatic Brain Injury on Skeletal Remodeling
Traumatic brain injury (TBI) is increasingly recognized as a systemic disorder with significant effects on skeletal biolog...
The Innate and Adaptive Immune Functions of Osteoblast-Lineage Cells
The Innate and Adaptive Immune Functions of Osteoblast-Lineage Cells
The osteoblast lineage has traditionally been viewed through a structural and metabolic lens, yet growing evidence indicat...
Stimulant Medications and Bone Health
Stimulant Medications and Bone Health
This review summarizes the potential impact of stimulant medications on bone health, to raise awareness and optimize their...
Testosterone and Bone Health in Men
Testosterone and Bone Health in Men
To elucidate the association between testosterone and skeletal health in men. In this review, i) we discuss the influence ...
Cone Beam Computed Tomography of Bonejaws in Patients With Primary Osteoporosis: A Systematic Review
Cone Beam Computed Tomography of Bonejaws in Patients With Primary Osteoporosis: A Systematic Review
This study aimed to investigate the potential of Cone Beam Computed Tomography (CBCT) parameters to identify primary osteo...
Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics
Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics
Osteoporosis remains a pressing worldwide health concern. Understanding disease progression and evaluating treatment respo...
Beyond Fracture Probability: Communicating the Full Consequences of Fracture and Contextualization
Beyond Fracture Probability: Communicating the Full Consequences of Fracture and Contextualization
Fracture risk calculators such as FRAX, the Garvan Fracture Risk Calculator, and QFracture are now embedded in clinical gu...
When X Does Not Mark the Spot: Autosomal Dominant and Recessive Forms of Renal Hypophosphatemic Rickets and Osteomalacia
When X Does Not Mark the Spot: Autosomal Dominant and Recessive Forms of Renal Hypophosphatemic Rickets and Osteomalacia
Conditions resulting in elevated fibroblast growth factor 23 (FGF23) cause hypophosphatemic rickets and osteomalacia. The ...
The Role of Short-Chain Fatty Acids and Derived Metabolites in Osteoporosis
The Role of Short-Chain Fatty Acids and Derived Metabolites in Osteoporosis
To investigate the role of short-chain fatty acids (SCFAs) in the pathogenesis of osteoporosis and their potential value a...
A Fragile Phosphate/Pyrophosphate Balance: From Essential Mineralization to Rare Calcifying Diseases
A Fragile Phosphate/Pyrophosphate Balance: From Essential Mineralization to Rare Calcifying Diseases
Calcification, the deposition of phosphate-calcium crystals, is essential for the development and function of mineralized ...
Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity
Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity
Bone matrix is a multiscale composite material mainly composed of collagen, crystalline apatite mineral, water, and a smal...
Pathophysiology of Femoral Fractures in Hypophosphatasia
Pathophysiology of Femoral Fractures in Hypophosphatasia
In this review, we will examine the pathophysiology, anatomy, biochemistry, and genotype-phenotype correlation of femoral ...
Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population
Bone Marrow Adipoq-lineage Progenitors: an Emerging Osteoclast Niche Cell Population
The purpose of this review is to summarize and highlight the recent findings of a novel osteoclastic niche centered on the...
Pathophysiology of Bone Fragility in Type 2 Diabetes Mellitus
Pathophysiology of Bone Fragility in Type 2 Diabetes Mellitus
Individuals with type 2 diabetes mellitus (T2DM) are at greater risk of fragility fractures compared to those without diab...
Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
Fracture Risk in Type 2 Diabetes: Systematic Review of Cardiovascular Outcome Trials with Glucagon Like Peptide Receptor Agonists
This systematic review examined the available evidence on fracture risk in people with type 2 diabetes (T2D) using cardiov...
Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update
Epidemiology, Pathophysiology and Management of Atypical Femur Fractures: an Update
To summarise recent publications addressing the epidemiology, pathogenesis and management of atypical femur fractures (AFF...
The Role of Osteoporosis in Spine Surgery and Current Management Strategies: A Review
The Role of Osteoporosis in Spine Surgery and Current Management Strategies: A Review
Osteoporosis is a systemic skeletal disease that presents unique challenges in spine surgery due to decreased bone mass, p...
Leveraging Proteomics and Proteogenomics for Understanding Osteoporosis and Other Musculoskeletal Diseases
Leveraging Proteomics and Proteogenomics for Understanding Osteoporosis and Other Musculoskeletal Diseases
Osteoporosis and musculoskeletal diseases, including osteoarthritis and sarcopenia, contribute substantially to global mor...
New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging
New Aspects of the Pathophysiology of Diabetic Bone Fragility – Type 2 Diabetes Mellitus as a Disease of Accelerated Aging
This review summarizes recent findings of the pathophysiology of bone fragility with a particular focus on type 2 diabetes...
The Periosteum in Health and Disease
The Periosteum in Health and Disease
The periosteum has long been recognized as being essential for bone growth and repair. More recently, its involvement has ...
Cancer Cell Dormancy in the Bone Microenvironment
Cancer Cell Dormancy in the Bone Microenvironment
Cancer cell dormancy in the bone microenvironment presents a major obstacle to curative therapy across multiple cancer typ...
Efficacy of Osteoanabolic Agents in Type 2 Diabetes Mellitus: a Meta-analysis and Review of the Literature
Efficacy of Osteoanabolic Agents in Type 2 Diabetes Mellitus: a Meta-analysis and Review of the Literature
To synthesize evidence on the efficacy of osteoanabolic therapies (teriparatide, abaloparatide, romosozumab) in adults wit...
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