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Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice
Declining FXR expression coordinates neonatal beta cell mass development with microbial bile acid metabolism maturation in mice
Diet switch during weaning induces gut microbiome maturation, accompanied by the formation of adequate functional beta cel...
LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogramming
LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogramming
Pancreatic beta cell dedifferentiation underlies the reversible reduction in beta cell mass and function in diabetes. Expl...
Evolution of islet autoantibodies in the Environmental Determinants of Islet Autoimmunity (ENDIA) prospective cohort
Evolution of islet autoantibodies in the Environmental Determinants of Islet Autoimmunity (ENDIA) prospective cohort
Islet autoantibodies herald early type 1 diabetes. However, less is known of the evolution of autoantibodies to the islet ...
Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA for the diagnosis of type 2 diabetes
Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA for the diagnosis of type 2 diabetes
The IDF has proposed 1 h plasma glucose (1 h PG) as a diagnostic test for type 2 diabetes. This study evaluated the utilit...
Inter- and intra-physician variability in insulin injection adjustments compared with Bayesian algorithm recommendations in type 1 diabetes
Inter- and intra-physician variability in insulin injection adjustments compared with Bayesian algorithm recommendations in type 1 diabetes
There is an unmet need for automated insulin adjustments for multiple daily injections in type 1 diabetes under unsupervis...
α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding
α7 Nicotinic acetylcholine receptor activation rescues mitochondrial dysfunction in gestational diabetes mellitus by competing with p66Shc for VDAC1 binding
Gestational diabetes mellitus (GDM) is associated with placental hormone-induced insulin resistance; however, the mechanis...
Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer
Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer
Type 2 diabetes has been associated with increased risk of colorectal cancer (CRC), but the specific diabetogenic pathways...
Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms
Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms
Fasting hyperinsulinaemia is a key feature of obesity and is implicated in diabetes progression. However, the following as...
Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort
Dietary intake of vitamins A, B, C, D and E and risk of islet autoimmunity and type 1 diabetes in genetically at-risk children: a prospective study from the DIPP birth cohort
In this prospective birth cohort study, we examined whether the dietary intake of A, B, C, D and E vitamins is associated ...
Effects of combined intraduodenal administration of lauric acid and -tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomised, crossover study
Effects of combined intraduodenal administration of lauric acid and -tryptophan on postprandial plasma glucose, glucoregulatory hormones and gastric emptying in type 2 diabetes: a double-blind, randomised, crossover study
In healthy men, lauric acid (C12) and l-tryptophan (Trp), when administered intraduodenally in loads of 1.26 and 0.42 kJ/m...
Efficacy of tirzepatide versus semaglutide in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial
Efficacy of tirzepatide versus semaglutide in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial
Simultaneous control of HbA1c, lipid profile, BP and body weight is essential for preventing chronic complications of type...
Aberrant STING signalling promotes endothelial dysfunction and neurovascular injury in diabetic retinopathy
Aberrant STING signalling promotes endothelial dysfunction and neurovascular injury in diabetic retinopathy
Diabetic retinopathy is a common complication of diabetes mellitus that is characterised by neurovascular dysfunction and ...
Prevalence of type 2 diabetes among global Indigenous adult populations: a systematic review
Prevalence of type 2 diabetes among global Indigenous adult populations: a systematic review
Despite evidence documenting high prevalence of type 2 diabetes among several Indigenous populations, a comprehensive syst...
Characterisation of human pancreatic mesenchymal stromal cells in type 1 diabetes
Characterisation of human pancreatic mesenchymal stromal cells in type 1 diabetes
Culture-expanded mesenchymal stromal cells (MSCs) reduce immune cell activation and improve islet functional survival. How...
Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice
Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice
Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent inducti...
Effects of insulin regimens for type 2 diabetes mellitus: a systematic review and network meta-analysis
Effects of insulin regimens for type 2 diabetes mellitus: a systematic review and network meta-analysis
Insulin therapy is essential for managing hyperglycaemia in type 2 diabetes mellitus when oral or non-insulin injectable a...
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic ...
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
Estimated GFRs utilising creatinine- (eGFRcreat) or cystatin C-based (eGFRcyst) equations can generate discrepant results ...
DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study
DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study
Diabetic peripheral neuropathy (DPN) and neuropathic pain (NP) are common complications of type 1 diabetes that can greatl...
Severe hypoglycaemia is associated with increased risk of adverse cardiovascular complications in adults with type 1 diabetes: risk mitigation using intermittently scanned continuous glucose monitoring
Severe hypoglycaemia is associated with increased risk of adverse cardiovascular complications in adults with type 1 diabetes: risk mitigation using intermittently scanned continuous glucose monitoring
It has been proposed that severe hypoglycaemia events (SHE) may increase the risk of adverse CVD complications in adults w...
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus
Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact...
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition
The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabete...
Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity
Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity
Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance....
Treatment discontinuation among users of GLP-1 receptor agonists and SGLT2 inhibitors in a national population of individuals with type 2 diabetes
Treatment discontinuation among users of GLP-1 receptor agonists and SGLT2 inhibitors in a national population of individuals with type 2 diabetes
Our aim was to assess treatment discontinuation, reinitiation and switching between drugs within the same drug class for g...
Duration and type of statin use and long-term risk of type 2 diabetes among men and women with hypercholesterolaemia: findings from three prospective cohorts
Duration and type of statin use and long-term risk of type 2 diabetes among men and women with hypercholesterolaemia: findings from three prospective cohorts
Findings from RCTs and observational studies indicate a positive association between statin use and risk of type 2 diabete...
Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter
Type 1 diabetes prediction in autoantibody-positive individuals: performance, time and money matter
Efficient prediction of clinical type 1 diabetes is important for risk stratification and monitoring of autoantibody-posit...
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Alt...
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokine would lead to antige...
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium su...
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