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NEJM Endocrinology
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SCI Abstract
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Risk of Progression and Costs of Care for Patients with Type 2 Diabetes and Chronic Kidney Disease
Chronic kidney disease (CKD) progression is associated with a significant incremental economic burden. Previous work has d...
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A Pragmatic Approach to Improving Management and Patient Flow for Painful Diabetic Neuropathy in UK Primary Care
Painful diabetic peripheral neuropathy (pDPN) affects approximately 25% of individuals with diabetes in the UK and remains...
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The Mechanisms of Inflammatory Factors and the Total Load of Cerebral Small Vessel Disease in Diabetic Retinopathy and Cognitive Impairment
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Effect of Automated Insulin Delivery System Therapy at Diagnosis on Metabolic Control in Children and Adolescents with Type 1 Diabetes
The primary goal of managing type 1 diabetes mellitus (T1D) is to achieve glycemic control and prevent both acute...
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Pharmacokinetic Characteristics of a Once-Weekly Combination Therapy of Insulin Icodec and Semaglutide Versus Its Separate Components in Chinese Individuals with Type 2 Diabetes
IcoSema is under development as a once-weekly injectable combination therapy of icodec (basal insulin) and semaglutide (gl...
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Efficacy and Safety of Once-Weekly Insulin Icodec in Indian Participants with Diabetes: Results from ONWARDS 1, 4, and 6 Studies
These analyses explored the efficacy and safety of once-weekly insulin icodec (icodec) in Indian participants with type&am...
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Real-World Effectiveness of Tirzepatide versus Semaglutide on HbA1c and Weight in Patients with Type 2 Diabetes
To evaluate real-world hemoglobin A1c (HbA1c) and weight change in adults initiating treatment with tirzepatide (dual gluc...
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A Multicenter, Prospective, Observational, and Single-Arm Interventional Study of Mirogabalin in Diabetic Peripheral Neuropathic Pain: Rationale and Design of Dia-NeP
The exact prevalence of and recent changes in diabetic polyneuropathy (DPN) and diabetic peripheral neuropathic pain (DPNP...
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Tubeless Insulin Pump Combined with a Cloud-Based Data Management Platform: Real-World Evidence from 14,765 French People with Diabetes
This study aimed to examine glucose metrics and insulin delivery patterns in children, adolescents, and adults with type&a...
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Identifying the Healthcare Burden of Diabetic Ketoacidosis: Economic Analysis and Mitigation Strategies for Adult Patients in the United Arab Emirates
Diabetic ketoacidosis (DKA) is a potentially fatal diabetes complication marked by hyperglycemia, ketonemia, and acidosis ...
Diabetes Therapy
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Protective Role of Serum β-Hydroxybutyrate in Early Diabetic Kidney Disease: A Longitudinal Study
β-Hydroxybutyrate (βHB), the most stable form of ketone bodies, has exhibited protective effects in metabolic an...
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Insights into the Mechanism of Action of Tirzepatide: A Narrative Review
Tirzepatide is the first dual long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-...
Diabetes Therapy
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Diabetes Educators: Understanding the Role of Finerenone in Chronic Kidney Disease Associated with Type 2 Diabetes Mellitus
People living with type 2 diabetes mellitus (T2DM) are at risk of developing diabetes-related complications such as chroni...
Diabetes Therapy
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A Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus
There is an unmet need for pharmacological therapies for children with type 2 diabetes mellitus (T2DM). We assessed the ef...
Diabetes Therapy
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Advances in Imaging Techniques for Assessing Myocardial Microcirculation in People with Diabetes
Microangiopathy is a key complication of diabetes, adversely effecting several organs including the heart, kidneys, eyes, ...
Diabetes Therapy
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The Prevalence of Atherosclerotic Cardiovascular Disease in Patients with Type 2 Diabetes in Jordan: The PACT-MEA Study
This study investigated the prevalence and clinical management of atherosclerotic cardiovascular disease (ASCVD) and ASCVD...
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Knowledge, Attitudes, and Practices in Neonatal Diabetes Mellitus Management: the JEnious-NeOnatal-DIabetes (JENODI) Survey
We aimed to explore the knowledge, attitude, and management of neonatal diabetes mellitus (NDM) among members of the Inter...
Diabetes Therapy
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Predictors of Composite Maternal and Fetal Outcomes among Pregnant Women with Early-Onset Type 2 Diabetes: A Cross-Sectional Study
The most common form of pregestational diabetes in pregnancy is type 2 diabetes, requiring strict metabolic monitoring owi...
Diabetes Therapy
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Clinical Profile and Treatment Patterns in Individuals with Type 2 Diabetes and Chronic Kidney Disease Who Initiate a GLP-1 Receptor Agonist: A Multinational Cohort Study
Novel therapies are emerging for the prevention of chronic kidney disease (CKD) progression in patients with type 2 diabet...
Diabetes Therapy
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Long- and Short-Term Cost-Effectiveness of Once-Weekly Semaglutide versus Dulaglutide for the Treatment of Type 2 Diabetes in China: A Hypothetical Modeling Exercise
This study aimed to evaluate the long- and short-term cost-effectiveness of once-weekly semaglutide versus dulaglutide for...
Diabetes Therapy
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Real-World Comparisons Between Glucagon-Like Peptide-1 Receptor Agonists and Other Glucose-Lowering Agents in Type 2 Diabetes: Retrospective Analyses of Cardiovascular and Economic Outcomes in England
Clinical trials have demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce the risk of major adver...
Diabetes Therapy
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Tirzepatide Was Associated with Improved Health-Related Quality of Life in Adults with Obesity or Overweight and Type 2 Diabetes: Results from the Phase 3 SURMOUNT-2 Trial
In SURMOUNT-2, a phase 3, randomized clinical trial, tirzepatide treatment resulted in clinically meaningful reduction in ...
Diabetes Therapy
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Comparing Efficacy of Chiglitazar, Pioglitazone, and Semaglutide in Type 2 Diabetes: A Retrospective Study
Type 2 diabetes (T2D) is a complex chronic metabolic disease characterized by insulin resistance, dyslipidemia, inflammati...
Diabetes Therapy
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Combining GLP-1 Receptor Agonists and SGLT2 Inhibitors in Type 2 Diabetes Mellitus: A Scoping Review and Expert Insights for Clinical Practice Utilizing the Nominal Group Technique
Treating type 2 diabetes has shifted from a gluco-centric approach to broader cardio-renal-metabolic strategy, dr...
Diabetes Therapy
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Once-Weekly Semaglutide Versus Sodium-Glucose Co-transporter 2 Inhibitors: Real-World Impact on Weight, HbA1c, and Healthcare Resource Utilization in Type 2 Diabetes (PAUSE)
Clinical trials have demonstrated greater glycemic control and weight loss with once-weekly (OW) semaglutide versus other ...
Diabetes Therapy
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The Association Between HbA1c Levels and the Risk of Myocardial Infarction and Stroke in People with Type 2 Diabetes: A Post Hoc Analysis of the REPRESENT Study
The aim of this work was to analyze the association between baseline glycated hemoglobin (HbA1c) levels and other factors ...
Diabetes Therapy
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Systematic Literature Review of the Impact of Type 2 Diabetes and Heart Failure Guideline Adherence on Clinical and Economic Outcomes
Type 2 diabetes mellitus (T2DM) is associated with comorbidities, particularly in the cardiovascular, renal, and metabolic...
Diabetes Therapy
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Association of Blood Heavy Metals with Diabetic Foot Ulcers in U.S. Adults with Diabetes: Insights from the 1999–2004 NHANES Data
Diabetic foot ulcers (DFU) are serious complications of diabetes. These ulcers significantly increase the risk of amputati...
Diabetes Therapy
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Preferences, Expectations and Attitudes on Basal Insulin from Patient–Physician–Payer Perspective: A Multi-stakeholder Survey by the Italian Diabetes Society (ITA4P Study)
Diabetes management often involves complex insulin regimens, posing significant challenges for patients and healthcare sys...
Diabetes Therapy
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Durability of Effectiveness Between Users of Once-Weekly Semaglutide and Dipeptidyl Peptidase 4 Inhibitors (DPP–4i) in US Adults with Type 2 Diabetes
Long-term effectiveness and durability of glucose-lowering medications are important considerations in managing type&n...
Diabetes Therapy
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