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Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade
Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade
Anti–PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized the treatment of many types of cancer over the...
NKG7 Is Required for Optimal Antitumor T-cell Immunity
NKG7 Is Required for Optimal Antitumor T-cell Immunity
Tumor antigen-specific CD8+ T cells play a critical role in antitumor immunity. Clinical trials reinvigorating the immune ...
NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy
NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy
IntroductionCytotoxic CD8+ T cells (CTL) are a crucial component of the immune system. They are capable of specifically ta...
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability
IntroductionImmunotherapy with immune checkpoint inhibitors (ICI) targeting PD-1/PD-L1 has revolutionized the treatment fo...
Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment
Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment
Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of t...
Immunomodulation of T- and NK-cell Responses by a Bispecific Antibody Targeting CD28 Homolog and PD-L1
Immunomodulation of T- and NK-cell Responses by a Bispecific Antibody Targeting CD28 Homolog and PD-L1
Immunomodulation of T- and NK-cell Responses by a Bispecific Antibody Targeting CD28 Homolog and PD-L1 ...
C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models
C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models
Many solid tumors have low levels of cytotoxic CD56dim natural killer (NK) cells, suggesting that CD56dim NK-cell exclusio...
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
IntroductionThe interest in using natural killer (NK) cell–based strategies in human cancer immunotherapy has been growing...
Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers
Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16+ Cancers
Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is P...
A New Year, A New Initiative
A New Year, A New Initiative
Thank you for sharing this Cancer Immunology Research article.NOTE: We request your email address only to inform the rec...
Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases
Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases
Single-agent immunotherapy has improved outcomes for patients with cancer, but only a minority of patients respond, necess...
Pulling the Strings of the Tumor Microenvironment
Pulling the Strings of the Tumor Microenvironment
Macrophages are in the spotlight of cancer immunotherapy research because they exert a wide spectrum of protumorigenic fun...
About the Rising Star
About the Rising Star
Thank you for sharing this Cancer Immunology Research article.NOTE: We request your email address only to inform the rec...
Imaging {alpha}-GalCer-Activated iNKT Cells in a Hepatic Metastatic Environment
Imaging {alpha}-GalCer-Activated iNKT Cells in a Hepatic Metastatic Environment
Patients with colorectal cancer frequently develop liver metastases after, and perhaps as a consequence of, lifesaving sur...
Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy
Engineering Principles for Synthetic Biology Circuits in Cancer Immunotherapy
Recent advances in biomolecular engineering have led to novel cancer immunotherapies with sophisticated programmed functio...
Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFN{gamma}-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFN{gamma}-Secreting Lymphocytes and IL12-Producing Dendritic Cells
Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-...
Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation
Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation
AbstractCombination immunotherapy treatments that recruit both innate and adaptive immunity have the potential to increase...
APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses
APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses
APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell–Mediated Antitumor Immune ...
B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression
B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression
IntroductionOvarian cancer is the eighth leading cause of cancer death in women worldwide, with an estimated figure of mor...
Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine
Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine
IntroductionOncodrivers are proteins overexpressed in tumor cells that promote proliferation and growth, but counteract ce...
BET Inhibition Enhances TNF-Mediated Antitumor Immunity
BET Inhibition Enhances TNF-Mediated Antitumor Immunity
BET Inhibition Enhances TNF-Mediated Antitumor Immunity Lisa C. Wellinger, Simon J. Hogg, Dane M...
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer
Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer
IntroductionImmunotherapy has emerged as a promising treatment for patients with advanced cancer. Immune system–based canc...
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors
A Sampling of Highlights from the Literature: Article Recommendations from Our Deputy and Senior Editors
Thank you for sharing this Cancer Immunology Research article.NOTE: We request your email address only to inform the rec...
Exosomal lncRNA-Mediated Intercellular Communication Promotes Glioblastoma Chemoresistance
Exosomal lncRNA-Mediated Intercellular Communication Promotes Glioblastoma Chemoresistance
1Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake Un...
Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited
Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited
T cells are the key players in eliminating malignant tumors. Adoptive transfer of tumor antigen-specific T cells and immun...
Glioblastoma Cell-Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance
Glioblastoma Cell-Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance
Glioblastoma Cell–Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoti...
Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets
Effective Treatment of Established Bone Metastases Can Be Achieved by Combinatorial Osteoclast Blockade and Depletion of Granulocytic Subsets
Osteoclast (OC) blockade has been successful in reducing tumor growth in bone in preclinical settings, but antiresorptive ...
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFN{gamma} and ICAM-1
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFN{gamma} and ICAM-1
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1 Chahrazade...
The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity
The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity
The SETDB1–TRIM28 Complex Suppresses Antitumor Immunity Jianhuang Lin, Dajiang Guo, Heng Liu, We...
Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents
Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents
AbstractImmune-checkpoint blockade has revolutionized cancer treatment. However, most patients do not respond to single-ag...
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