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Obituary: Professor Farrokh Modabber (1940–2025) – Architect of Leishmaniasis Immunology and Champion of Global Health Equity
Professor Farrokh Modabber, a prominent immunologist whose early research laid foundational insights into cellular immunol...
A Novel Homozygous CGA > TGA Mutation at Codon 123 (Exon 6) of B-Linker Protein (BLNK) as a Potential Cause of ‎Hepatopathy and Rickets: A Case Report
BLNK deficiency is a subtype of autosomal recessive immune disorders that involves a lack of B cells,  agammaglobulinemia,...
Hypomethylation of OAS2 and OAS3 Gene Promoters: Insights into the ‎Pathogenesis of Systemic Lupus Erythematosus
Background: DNA methylation plays a key role in systemic lupus erythematosus (SLE) by regulating gene expression and impac...
Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson’s disease: Focus on Emerging Cytokines
Background: Parkinson’s disease (PD) is increasingly recognized as a condition driven by both central and peripheral infla...
Modulation of the CD200/CD200R Axis by IFN-β Treatment in a Mouse Model of Experimental Autoimmune Encephalomyelitis
Background: Interferon-b (IFN-β), a glycoprotein released during viral infections, plays a crucial role in modulating T ce...
Extracellular Vesicles from miR-146a Overexpressing Mesenchymal Stem Cells Attenuate ‎Imiquimod-Induced Psoriasis by Regulating Cytokine Expression
Background: Psoriasis is a chronic inflammatory skin disorder characterized by elevated levels of proinflammatory cytokine...
Interleukin-14 prevents cytarabine or irradiation induced neutropenia via JAK/STAT3 signaling
Background: Severe neutropenia significantly increases the risk of bacterial infections. Recent studies have shown that th...
Does Endoplasmic Reticulum (ER) Stress Contribute to T-cell Exhaustion in B-ALL?
Background: Glucose deprivation in T lymphocytes can trigger compensatory metabolic pathways, potentially contributing to ...
The Pro-inflammatory Functions of Type 1 CD 8+ T Cells and Interleukin-17-producing Cluster of Differentiation 8+ T Cells are Exhausted by Cholesterol in Atherosclerosis
Background: CD8+ T cells have been found to accumulate in atherosclerotic plaques. However, the specific role of CD8+ T ce...
Analysis of the Blood Levels of NK and NKT Cells in Patients with Severe SARS-CoV-2 Infection
Background: Clinical manifestations SARS-CoV-2 infection are variable, ranging from asymptomatic to pneumonia, and differe...
Effects of Intrauterine Infusion of G-CSF and HCG on Peripheral Blood Treg and Pregnancy Outcome in Patients with Thin Endometrium Undergoing Frozen-thawed Embryo Transfer
Background: Patients with thin endometrium undergoing frozen-thawed embryo transfer often encounter challenges with pregna...
Blood Cytokine Profile in Breast Cancer: Focusing on Differences among Molecular Subtypes
Background: Breast cancer is the leading cause of cancer-related deaths in women. Cytokines have been linked to various ca...
Design and Cytotoxicity Evaluation of a Cancer-targeting Immunotoxin Based on a Camelid Nanobody-PE Fusion Protein
Background: Developing effective targeted treatment approaches to overcome drug resistance remains a crucial goal in cance...
Evaluation of Metastasis Inhibition by ABD-IL-2 Compared to Human IL-2 in a Breast Cancer Mouse Model
Background: Interleukin-2 (IL-2) is a well-known cytokine that plays a crucial role in stimulating immune cells, including...
Antitumor Activity and Immunostimulant Properties of Liposomes Containing Rosemary Extract on a Mouse Model of Colorectal Cancer
Background: Rosemary (Ros) is a member of the Lamiaceae family known for its antitumor properties. However, its low water ...
Gamma-delta T Cells in Bladder Cancer Draining Lymph Nodes
Background: Gamma-delta (γδ) T cells are a distinct subset of T cells with a receptor composed of γ and δ chains. Their ab...
Human Umbilical Cord Mesenchymal Stem Cells and Their Extracellular Vesicles Modulate Pro- and Anti-Inflammatory Cytokines in Ligature-induced Periodontitis
Background: Periodontitis is a persistent inflammatory condition that impacts the tissues supporting the teeth, ultimately...
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia
Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (N...
Rescue of HLH with T and B Lymphocyte Involvement Due to Epstein-Barr Virus by PD-1 Inhibitor/Ruxolitinib and Rituximab Combination Regimens: A Case Report
Hemophagocytic lymphohistiocytosis (HLH) is a fatal clinical syndrome. The most common cause of secondary HLH is Epstein-B...
High-free Fatty Acid Treatment Induced Anti-inflammatory Changes in a Natural Killer (NK) Cell Line
Background: Natural killer (NK) cells play a role in the pathogenesis of various metabolic diseases related to obesity. Wh...
Antibody Production After COVID-19 Vaccination in Patients with Inborn Errors of Immunity
Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with Inborn errors of immunity (IEI).Objectiv...
Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips
Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite...
Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease
Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory respo...
Neutrophil Extracellular Traps Formation and Citrullinated Histones 3 Levels in Patients with Kawasaki Disease
Background: Kawasaki disease (KD) is a vasculitis associated with vascular injury and autoimmune response. Inflammatory fa...
Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans
Background: Buerger’s disease, also known as Thromboangiitis Obliterans (TAO), is a progressive, inflammatory vascular dis...
Vol 20, Supplementary Issue, 16th International Congress of Immunology and Allergy
We are delighted to share the Abstract Book of the "16th International Congress of Immunology and Allergy". The ...
IJI, Vol 20, Supplementary Issue, 16th International Congress of Immunology and Allergy
We are delighted to share the Abstract Book of the "16th International Congress of Immunology and Allergy". The ...
Effects of Blocking NLRP3 Inflammasome on Type II Innate Lymphoid Cell Response in Allergic Rhinitis
Background: Type 2 innate lymphoid cells (ILC2s) and NLRP3 inflammasome are related to allergic and inflammatory responses...
Implications of Complement Imbalance in COVID-19: A Molecular Mechanistic Discussion on the Importance of Complement Balance
Two central questions in COVID-19 treatment which should be considered are: “How does the imbalance of the complement syst...
Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response
Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. ...
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