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Natural polysaccharides as multifunctional anti-cancer agents: structure-activity relationships, mechanisms of action, and therapeutic potential
Cancer remains a formidable global health challenge, characterized by alarmingly high incidence and mortality rates. Tradi...
Reversible cerebral vasoconstriction syndrome following ciltacabtagene autoleucel therapy for relapsed multiple myeloma: a case report
Ciltacabtagene autoleucel (cilta-cel), a BCMA-directed CAR-T therapy, is approved for relapsed/refractory multiple myeloma...
Neoantigen-based cancer vaccines: a mechanistic and clinical review of personalised melanoma immunotherapy
Melanoma, owing to its high tumour mutational burden (TMB) and inherent immunogenicity, has emerged as a prime target for ...
Dual immune armies in glaucoma: microglia and monocyte-derived macrophages
Glaucoma is a leading cause of irreversible blindness globally, with the core pathological feature being progressive degen...
Heterologous expression of interferon-stimulated genes reveals conserved anti-Toxoplasma properties between human and porcine cells
Toxoplasma is a zoonotic parasite that can cause life-threatening illness in humans and animals. The similarities in Toxop...
Lactylation at the crossroads of metabolism and epigenetics in neuroinflammation
Lactate has moved from being viewed as an inert glycolytic end-product to a pleiotropic metabolite that shapes cellular si...
Varicella-zoster virus-associated central nervous system infection in immunocompromised vs. immunocompetent herpes zoster patients: a comparative study
ObjectivesVaricella-zoster virus (VZV) is a significant pathogen of viral central nervous system (CNS) infections. There a...
Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence
IntroductionChronic radiation proctitis (RP) is characterized by persistent inflammation and impaired tissue repair. This ...
Ferroptosis inhibition and AMPK activation: key mechanisms of soy isoflavones against cerebral injury
BackgroundCerebral ischemia–reperfusion injury (CIRI) remains a major cause of neurological disability and lacks effective...
The role of ALOX15 in inflammation-related diseases
Arachidonate 15-lipoxygenase (ALOX15) is a key member of the lipoxygenase family, catalyzing the oxidation of polyunsatura...
Immunometabolic remodeling: new perspectives and strategies for liver transplantation
Liver transplantation (LT) has become the optimal therapeutic strategy for end-stage liver disease. Beyond chronic conditi...
Liquid biopsy in cancer drug resistance: real-time monitoring, mechanistic insights, and translational applications
Liquid biopsy provides a non-invasive approach for cancer detection. It examines tumor-associated components in blood and ...
Astragaloside IV suppresses neuroinflammation via PI3K/Akt/NF-κB to ameliorate cerebral ischemia-reperfusion injury based on network pharmacology analysis and experimental validation
AimThis study aimed to systematically investigate the therapeutic effects and underlying mechanisms of ASIV against cerebr...
Erythrocyte membrane–liposome coating sustains circulation stability and targeted tumor therapy of CAR-T cells
BackgroundCAR-T therapy is limited by off-target sequestration in liver, spleen, and lungs, which reduces tumor delivery a...
The therapeutic potential of compounds from natural products for alleviating depression by targeting P2X7 receptor-mediated proinflammatory signaling pathways
Depression is a prevalent neuropsychiatric disorder with high incidence and causing severe disability, representing a clin...
Identification of herbal formula Huatanqushihuoxue formula as a potential therapeutic agent for metabolism-related fatty liver disease: a multi-omics and network pharmacology approach
ObjectiveThis study aimed to evaluate the therapeutic effect of the traditional Chinese medicine compound Huatan Qushi Huo...
Genomic characterization of rabies virus glycoprotein co-expressing CD70 CAR-T cells during killing of glioma cells in vitro
BackgroundChimeric antigen receptor T cell therapy has limited efficacy in the treatment of glioma due to the blood-brain ...
Correction: Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren’s disease
A correction refers to a change to their article that the author wishes to publish after publication. The publication of t...
XIST expression and hypermethylation of the X chromosome in males with systemic lupus erythematosus
IntroductionSystemic Lupus Erythematosus (SLE) exhibits a pronounced sex bias, affecting females approximately nine times ...
Correction: Differences in the peripheral blood immune landscape between early-onset and late-onset colorectal cancer
This article is a correction to:Differences in the peripheral blood immune landscape between early-onset and late-onset co...
The impact of immune-related adverse events on the outcome of advanced gastric cancer patients with immune checkpoint inhibitor treatment
IntroductionAccording to GLOBOCAN 2022, gastric cancer (GC) accounted for the fifth incidence with 968,000 novel cases and...
Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma
IntroductionCutaneous T-cell lymphoma (CTCL) encompasses a heterogenous group of non-Hodgkin T-cell lymphomas characterize...
Commentary: BAFF blockade attenuates DSS-induced chronic colitis via inhibiting NLRP3 inflammasome and NF-кB activation
With a discerning and inquisitive interest, we read the paper "BAFF Blockade Attenuates DSS-Induced Chronic Colit...
Mechanisms of HIV-immunologic non-responses and research trends based on gut microbiota
1 IntroductionAcquired immunodeficiency syndrome (AIDS) is an infectious disease with immune deficiency caused by infectio...
Beneficial effects of ultrafine bubble shower on a mouse model of atopic dermatitis
1 IntroductionAtopic dermatitis (AD) is a common chronic inflammatory disease characterized by purpuric relapsing skin ery...
Understanding the tumor microenvironment for personalized immunotherapy in early-onset head and neck squamous cell carcinoma
1 IntroductionCancer remains a leading cause of morbidity and mortality worldwide, imposing a substantial burden on global...
Editorial: Community series in recent advances in potential biomarkers for rheumatic diseases and in cell-based therapies in the management of inflammatory rheumatic diseases, volume II
This Research Topic focuses on recent advances in the identification of diagnostic, prognostic and predictive biomarkers f...
Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing
IntroductionRheumatoid arthritis (RA) is a chronic autoimmune disorder marked by persistent synovial inflammation, leading...
S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines
IntroductionThe novel coronavirus, SARS-CoV-2, emerged in 2019, leading to a global pandemic with profound public health i...
Case report: Rituximab combined with plasma exchange treatment for systemic lupus erythematosus complicated with thrombotic microangiopathy and non-cirrhotic portal hypertension
1 IntroductionSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ and multi-system in...
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