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Skin Treg cells set the tone for neuronal activation
Skin Treg cells set the tone for neuronal activation
A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their pr...
The promise of immunotherapy for central nervous system tumours
The promise of immunotherapy for central nervous system tumours
The nervous and immune systems are intricately linked to one another through bi-directional crosstalk. Given the limited t...
ILC2–neuron cross-talk regulates pain sensitivity and gait
Group 2 innate lymphoid cells are crucial for maintaining nerve structure and pain thresholds.
Proteotoxic shock is a mechanistic driver of T cell exhaustion
A proteotoxic stress response specific to exhausted T cells represents a target for cancer immunotherapy.
Enterobacteriaceae-derived cadaverine manipulates gut macrophage metabolism
Depending on context and concentration, the polyamine cadaverine can promote pro- or anti-inflammatory macrophage polariza...
Autoimmune T cells identified in ALS
Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferenti...
Targeting organelle function in T cells for cancer immunotherapy
Targeting organelle function in T cells for cancer immunotherapy
Organelles are the internal batteries, gears, actuators, 3D printers and transmitters that drive cell function. Their comp...
Microenvironmental regulation of solid tumour resistance to CAR T cell therapy
Microenvironmental regulation of solid tumour resistance to CAR T cell therapy
Chimeric antigen receptor (CAR) T cell therapy holds significant promise for the treatment of cancer; however, its efficac...
Faulty mitochondria jump between tumours and T cells
Faulty mitochondria jump between tumours and T cells
To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism...
HDAC9 association with heart disease linked to NLRP3 inflammasome activation
HDAC9 association with heart disease linked to NLRP3 inflammasome activation
Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a...
Immune-mediated strategies to solving the HIV reservoir problem
Immune-mediated strategies to solving the HIV reservoir problem
Antiretroviral therapy (ART) has markedly improved the life-expectancy of people living with HIV. However, during both HIV...
Meningeal Treg cells keep brain in balance
Meningeal Treg cells keep brain in balance
A study in Science Immunology shows that meningeal regulatory T (Treg) cells limit the activation, proliferation and paren...
Trogocytosis of CARs depends on transmembrane domains
Immune cells can exchange membrane-bound molecules via horizontal protein transfer, a poorly understood process termed tro...
IL-27 boosts cytotoxic T cells in cancer
Cytotoxic T lymphocytes (CTLs) in tumours are often dysfunctional. Bréart et al. investigated the association between cyto...
Reduced duration of natural protection in the Omicron era
The arrival of the Omicron variant of SARS-CoV-2 in late 2021 marked a major shift during the COVID-19 pandemic, as the vi...
Neutrophils release inflammation-resolving vesicles
Neutrophils release inflammation-resolving vesicles
Hsu et al. report in Cell that the release of complement-inhibiting vesicles by neutrophils as they age is a self-resolvin...
Sleep deprivation whips up cytokine storm
A new mouse model of sleep deprivation reveals a potent pathway by which sleep-related changes in prostaglandin D2 in the ...
TCRs and AI: the future is now
A preprint by Fast et al. describes TAPIR, a computational tool for predicting TCR–pMHC interactions.
Adipose tissue maintains healthy joint fibroblasts via cortisol signalling
A preprint by Faust et al. determines mechanisms of crosstalk between adipocytes and fibroblasts in the joint relevant to ...
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations
The approval of the first immune checkpoint inhibitors provided a paradigm shift for the treatment of malignancies across ...
Neonatal monocytes suppress adult TH17 cell responses in skin
A preprint by Dhariwala et al. reports that monocytes in the skin of newborn mice suppress microbiota-driven inflammatory ...
Brain regulatory T cells
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into...
Author Correction: Protein kinases: drug targets for immunological disorders
Authors and AffiliationsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Nationa...
Communicating science effectively in times of crisis: time for reflection
Communicating science effectively in times of crisis: time for reflection
Gary Koretzky served as president of the American Association of Immunologists (AAI) from 2021 to 2022. During this tenure...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Lipid metabolism extinguishes cGAS–STING-induced inflammation
Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of...
Role of the microbiota in response to and recovery from cancer therapy
Role of the microbiota in response to and recovery from cancer therapy
Our understanding of how the microbiota affects the balance between response to and failure of cancer treatment by modulat...
Low serotonin linked to long COVID
Low serotonin linked to long COVID
A study shows that individuals with long COVID have low levels of serotonin, which explains the neurocognitive impairments...
Host IgM facilitates mating in Leishmania
The parasite Leishmania, which causes the debilitating disease leishmaniasis, is spread by sandflies and affects millions ...
Gut fungi have lasting effect on immune response to severe COVID-19
A study by Kusakabe et al. reports increased antibody responses to specific fungi in individuals with severe COVID-19, par...
NMDAR-directed CAAR T cells show promise for autoimmune encephalitis
N-methyl-d-aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis. It is usually treated by un...
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