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The Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor
The Activating receptor KIR2DS2 bound to HLA‐C1 reveals the novel recognition features of activating receptor
Abstract Killer cell immunoglobulin-like receptors (KIRs) are important receptors for regulating the killing of virus-infe...
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy
Eosinophil plays a crucial role in intestinal mucositis induced by antineoplastic chemotherapy
Abstract Mucositis is a major clinical complication associated with cancer treatment and may limit the benefit of chemothe...
Metabolic manipulation of the tumour immune microenvironment
Metabolic manipulation of the tumour immune microenvironment
Abstract In the past few years, the evolution of immunotherapy has resulted in a shift in cancer treatment models. However...
Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms
Arid1a promotes thymocyte development through β‐selection‐dependent and β‐selection‐independent mechanisms
Abstract Early T-cell development from CD4− CD8− double-negative (DN) stage to CD4+ CD8+ double-po...
New‐onset autoimmune phenomena post COVID‐19 vaccination
New‐onset autoimmune phenomena post COVID‐19 vaccination
Abstract Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
Double‐negative T cells: setting the stage for disease control or progression
Double‐negative T cells: setting the stage for disease control or progression
Summary Double-negative T cells (DN) are present at relatively low frequencies in human peripheral blood, and are characte...
Arid1a promotes thymocyte development through β‐selection‐dependent and ‐independent mechanisms
Arid1a promotes thymocyte development through β‐selection‐dependent and ‐independent mechanisms
Abstract Early T cell development from CD4-CD8- double negative (DN) stage to CD4+CD8+ double positive (DP) stage in the t...
Meet the new Editor‐in‐Chief of Immunology: Greg M. Delgoffe, Ph.D
Meet the new Editor‐in‐Chief of Immunology: Greg M. Delgoffe, Ph.D
In this first issue of Immunology as Editor-in-Chief, I wanted to take the time to introduce myself to our readers and sci...
Rabaptin5 acts as a key regulator for Rab7l1‐mediated phagosome maturation process
Rabaptin5 acts as a key regulator for Rab7l1‐mediated phagosome maturation process
Abstract Phagosome maturation is an important innate defense mechanism of macrophages against pathogen infections. Phagoso...
Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells
Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterization of avian conventional dendritic cells
Abstract Conventional dendritic cells (cDC) are bone marrow-derived immune cells that play a central role in linking innat...
Anti‐CD52 antibody treatment in murine experimental autoimmune encephalomyelitis induces dynamic and differential modulation of innate immune cells in peripheral immune and central nervous systems
Anti‐CD52 antibody treatment in murine experimental autoimmune encephalomyelitis induces dynamic and differential modulation of innate immune cells in peripheral immune and central nervous systems
Abstract Anti-CD52 antibody (anti-CD52-Ab) leads to a rapid depletion of T and B cells, followed by reconstitution of immu...
Blocking T cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity
Blocking T cell egress with FTY720 extends DNA vaccine expression but reduces immunogenicity
Abstract Optimal immunogenicity from nucleic acid vaccines requires a balance of antigen expression that effectively engag...
Dynamic intron retention modulates gene expression in the monocytic differentiation pathway
Dynamic intron retention modulates gene expression in the monocytic differentiation pathway
Abstract Monocytes play a crucial role in maintaining homeostasis and mediating a successful innate immune response. They ...
Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers
Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid organ cancers
Abstract Accurate assessment of SARS-CoV-2 immunity is critical to evaluating vaccine efficacy and devising public health ...
BCG mediated protection against M. tuberculosis is sustained post malaria infection independent of parasite virulence
BCG mediated protection against M. tuberculosis is sustained post malaria infection independent of parasite virulence
Abstract Tuberculosis (TB) and malaria remain serious threats to global health. Bacillus Calmette Guerin (BCG), the only l...
Diverse myeloid cells are recruited to the developing and inflamed mammary gland
Diverse myeloid cells are recruited to the developing and inflamed mammary gland
Summary The immune system plays fundamental roles in the mammary gland, shaping developmental processes and controlling in...
Identifying SARS‐CoV‐2 “memory” NK cells from COVID‐19 convalescent donors for adoptive cell therapy
Identifying SARS‐CoV‐2 “memory” NK cells from COVID‐19 convalescent donors for adoptive cell therapy
Abstract COVID-19 disease is the manifestation of Syndrome coronavirus 2 (SARS-CoV-2) infection, which is causing a worldw...
MicroRNA‐590‐3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice
MicroRNA‐590‐3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice
Abstract T helper 17 (Th17) cells have a pathogenic effect in many autoimmune diseases. Inhibition of Th17 cells can allev...
Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterisation of avian conventional dendritic cells
Development of novel reagents to chicken FLT3, XCR1 and CSF2R for the identification and characterisation of avian conventional dendritic cells
ABSTRACT Conventional dendritic cells (cDC) are bone marrow derived immune cells that play a central role in linking innat...
NLRP3 Knockout Enhances Immune Infiltration and Inflammatory Responses and Improves Survival in a Burn‐Sepsis Model
NLRP3 Knockout Enhances Immune Infiltration and Inflammatory Responses and Improves Survival in a Burn‐Sepsis Model
ABSTRACT Although sepsis in burn patients is a major contributor to mortality, treatments are not always effective and und...
We need to talk about neutrophils
We need to talk about neutrophils
Over the past 15 years, our understanding of neutrophils has undergone an enormous shift – particularly for those of us wh...
A comprehensive review of IL‐26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases, and infections
A comprehensive review of IL‐26 to pave a new way for a profound understanding of the pathobiology of cancer, inflammatory diseases, and infections
Abstract Cytokines are considered vital mediators of the immune system. Down- or upregulation of these mediators is linked...
Human Immune Polymorphisms Associated with the Risk of Cryptococcal Disease
Human Immune Polymorphisms Associated with the Risk of Cryptococcal Disease
Abstract Cryptococcus neoformans is an opportunistic fungal pathogen that can cause lethal cryptococcal meningitis (CM) in...
Neutrophil and remnant clearance in immunity and inflammation
Neutrophil and remnant clearance in immunity and inflammation
ABSTRACT Neutrophil-centered inflammation and flawed clearance of neutrophils cause and exuberate multiple pathological co...
A specialist antigen storage compartment in dendritic cells to sustain cross‐presentation
A specialist antigen storage compartment in dendritic cells to sustain cross‐presentation
Dendritic cells (DCs) play a key role in inducing, shaping and maintaining adaptive immune responses. DCs act as professio...
LNA oligonucleotide mediates an anti‐inflammatory effect in autoimmune myocarditis via targeting lactate dehydrogenase B
LNA oligonucleotide mediates an anti‐inflammatory effect in autoimmune myocarditis via targeting lactate dehydrogenase B
Abstract Treatment of myocarditis is often limited to symptomatic treatment due to unknown pathomechanisms. In order to id...
LNA‐Oligonucleotide mediates an anti‐inflammatory effect in autoimmune myocarditis via target of lactate dehydrogenase B
LNA‐Oligonucleotide mediates an anti‐inflammatory effect in autoimmune myocarditis via target of lactate dehydrogenase B
Abstract Treatment of myocarditis is often limited to symptomatic treatment due to unknown pathomechanisms. In order to id...
The role of Bruton's tyrosine kinase in the immune system and disease
The role of Bruton's tyrosine kinase in the immune system and disease
Abstract Bruton's tyrosine kinase (BTK) is a TEC kinase with a multifaceted role in B-cell biology and function, highlight...
Immunomodulatory Functions of TRPM7 and its Implications in Autoimmune Diseases
Immunomodulatory Functions of TRPM7 and its Implications in Autoimmune Diseases
Abstract Autoimamune disease is an inappropriate response to one's tissues due to a break in immune tolerance and exposure...
Haemoglobin drives inflammation and initiates antigen spread and nephritis in lupus
Haemoglobin drives inflammation and initiates antigen spread and nephritis in lupus
Abstract Haemoglobin (Hb) has well-documented inflammatory effects and is normally efficiently scavenged; clearance mechan...
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