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Genomic similarity to quantitatively evaluate the reassortment potential of H7N9 with other subtypes of avian influenza viruses
IntroductionThe H7N9 influenza virus poses a significant public health threat due to its potential for reassortment and cr...
Integrated mechanistic and bioinformatics analysis of a traditional Chinese medicine compound MangHuang solution against Candida albicans
IntroductionThe growing prevalence of drug-resistant pathogens urgently calls for new treatment strategies. Traditional Ch...
Taraxacum alleviates ulcerative colitis, accompanied by the modulation of gut microbiota and restoration of intestinal barrier integrity
BackgroundPrevious studies have shown that Taraxacum(TM) possesses strong antioxidant, anti-inflammatory, and antibacteria...
Clinical characteristics and risk factors analysis of Clostridioides difficile infection in ulcerative colitis patients during biologic therapy
ObjectiveTo investigate the risk factors for Clostridioides difficile infection (CDI) in patients with ulcerative colitis ...
Characterization of a Klebsiella pneumoniae mutant strain wGF 1–2 with attenuated virulence, altered morphology, and reduced biofilm formation
IntroductionThe global rise of antimicrobial resistance has positioned multidrug-resistant Klebsiella pneumoniae as a crit...
Vitamin D deficiency in mice modulates oral microbiome stability over time and leads to changes in host inflammatory gene expression pathways
IntroductionWe previously showed that vitamin D deficiency leads to gingival inflammation and alveolar bone loss in mice, ...
First report on the biological characteristics of carbapenem-resistant Salmonella Thompson with blaCMY-2 production combined with OmpC and OmpF outer membrane protein deficiency in bloodstream infection
ObjectivesTo investigate the antimicrobial resistance profile and molecular characteristics of the first carbapenem-resist...
Duodenal microbiota profiling and its effects on gastrointestinal tract dysfunction
BackgroundDuodenal microbiota has been proposed to be associated with gastrointestinal dysfunction, but population-based d...
Characteristics of the resistome and the potential for bloodstream infections in patients with gut colonization by Klebsiella pneumoniae undergoing hematopoietic stem cell transplantation
BackgroundHematopoietic stem cell transplantation (HSCT) patients are at high risk for intestinal colonization by Klebsiel...
Megasphaera in the gut microbiome and cancer: from Megasphaera elsdenii dysbiosis to Megasphaera sp. XA511 in tumor microenvironments
Growing evidence suggests that the gut microbiome and specific gut microbes influence carcinogenesis both within the gastr...
Molecular strategies of Salmonella Typhimurium: from host cell invasion and metabolic hijacking to immune evasion
Salmonella enterica serovar Typhimurium (S. Typhimurium), a prevalent zoonotic pathogenic bacterium, has its pathogenicity...
Genetic variations in three insecticide targets in the disease vector Culex quinquefasciatus from Mianyang, China: simultaneous detection of novel mutations RDL A296G and VGSC A1007T
Culex quinquefasciatus is a major vector of filariasis and Japanese encephalitis in China. The application of insecticides...
A needle-free intradermal PEDV S protein vaccine elicits protective lactogenic immunity in piglets
Porcine epidemic diarrhea virus (PEDV) remains a major threat to the global swine industry, with genotype II (GII) strains...
Severe periodontitis patients with well-controlled type 2 diabetes display a distinct subgingival microbiome with increased Saccharibacteria compared to systemically healthy controls
IntroductionType 2 diabetes mellitus (T2DM) is a major systemic risk factor that exacerbates periodontitis, with microbial...
New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on Trypanosoma cruzi in vitro and in vivo
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is currently a global health problem. Its multiple for...
Six-month surveillance of Candida parapsilosis in Tyrol, Austria: high-risk ST11 lineage and early, heterogeneous fluconazole resistance
IntroductionCandida parapsilosis is an emerging cause of invasive candidiasis, driven by nosocomial transmission, environm...
Bioinformatics based design of thermostable virus-like particles-based vaccine for foot-and-mouth disease serotype A and in-vivo evaluation in guinea pigs
BackgroundFoot-and-mouth disease (FMD) is a contagious disease affecting cloven footed animals. Existing vaccines although...
The role and significance of the PI3K/Akt-mTOR signaling pathway in infectious diseases
The PI3K/Akt-mTOR signaling pathway, as a highly conserved and crucial intracellular signal transduction network, is deepl...
Recent progress in understanding ferroptosis mechanisms in infectious diseases
Ferroptosis, characterized by lipid peroxidation and iron-dependent oxidative damage, is a crucial factor in various disea...
Amoebae: beyond pathogens- exploring their benefits and future potential
1 IntroductionAmoebae, within the Protista kingdom, encompasses over 17,000 species, exhibiting diverse lifestyles from fr...
Prolonged fecal shedding of replication-competent virus, lasting immune activation, and intestinal inflammation in a rhesus macaque after experimental SARS-CoV-2 infection
1 IntroductionThe disease caused by SARS-CoV-2, COVID-19, was initially regarded as a respiratory syndrome. However, it so...
Immunogenicity and safety of the fourth dose of quadrivalent human papillomavirus (HPV) vaccine in immunosuppressed women who did not seroconvert after three doses
1 IntroductionPeople living with human immunodeficiency virus (PLWH), solid organ transplant (SOT) recipients, and other i...
Gut microbiome and clinical and lifestyle host factors associated with recurrent positive RT-PCR for SARS-CoV-2
Gut microbiome and clinical and lifestyle host factors associated with recurrent positive RT-PCR for SARS-CoV-2
1 IntroductionCoronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
Characterization of glycogen-related glycoside hydrolase glgX and glgB from Klebsiella pneumoniae and their roles in biofilm formation and virulence
1 IntroductionExcessive glucose ingested by organisms is stored in the form of inactive polymers, with glycogen serving as...
Editorial: Factors associated with drug resistance and virulence of Mycobacterium tuberculosis
The standard treatment regime for drug-sensitive TB is two months of therapy with rifampicin (RIF), isoniazid (INH), pyraz...
Diagnosis and insight into the unique lung microbiota of pediatric pulmonary tuberculosis patients by bronchoalveolar lavage using metagenomic next-generation sequencing
1 IntroductionTuberculosis (TB) remains a major public health problem for children and adolescents. In 2022, 7.5 million p...
Longitudinal ozone exposure and SARS-CoV-2 infection in late pregnancy: a retrospective cohort study
1 IntroductionThe global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome ...
Comparative transcriptomic and molecular biology analyses to explore potential immune responses to Vibrio parahaemolyticus challenge in Eriocheir sinensis
1 IntroductionChinese mitten crabs (Eriocheir sinensis) are a valuable aquaculture species in East Asia (Sun et al., 2013;...
Multi-epitope vaccines: a promising strategy against viral diseases in swine
1 IntroductionViral infections significantly impact the swine industry, particularly those affecting the respiratory, repr...
Increased in vitro antimicrobial resistance of Mycoplasma pneumoniae isolates obtained from children in Beijing, China, in 2023
1 IntroductionMycoplasmas are the smallest and simplest self-replicating prokaryotic organisms that often parasitize mucus...
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