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Optimizing post-transplantation cell therapies to enhance graft-versus-leukemia effects in hematological malignancies
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for patients with hematologic mali...
Roles of endothelial cells during infection
Volume 97, December 2025, 102648Author links open overlay panel, , , , , Endothelial cells (ECs) integrate immune and vasc...
Human inborn errors of type I interferon–independent intrinsic immunity in nonleukocytic cells
Volume 97, December 2025, 102651Author links open overlay panel, , ‘Intrinsic immunity’ is often used to refer to mechanis...
Protective or pathogenic? Tuft cells shape divergent immune outcomes in helminth and viral infections
Barrier tissues like the lung and gut serve as the primary interface between the host and the microbial world, requiring s...
Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity
At mucosal barriers, the best outcome for the host requires a balance between defending against harmful exposures while al...
Antiviral responses in peripheral and brain neurons
Volume 97, December 2025, 102678Author links open overlay panel, , Neurotropic viruses represent a public health challenge...
Challenges in diagnosis of sarcoidosis
Volume 97, December 2025, 102652Author links open overlay panel, , Purpose of reviewDiagnosing sarcoidosis remains challen...
From genes to granulomas: the genetic blueprint of sarcoidosis
Volume 97, December 2025, 102663Author links open overlay panel, Highlights•Sarcoidosis affects all ancestries, underscori...
When granulomatous inflammation becomes visible: insights into cutaneous sarcoidosis
Cutaneous involvement of sarcoidosis can provide important insights into the presence and prognosis of systemic involvemen...
Treating sarcoidosis: when less is more
Sarcoidosis is a multisystem condition characterised by non-necrotising granulomatous inflammation, with pulmonary involve...
T follicular helper cell development during malaria
Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicu...
Pulmonary transfusion reactions as an immunological spectrum disorder
Volume 98, February 2026, 102689Author links open overlay panel, , , Transfusion-associated circulatory overload (TACO) an...
Role of ion channels in immune regulation of psoriasis
Volume 98, February 2026, 102688Author links open overlay panel, , , , , Psoriasis is a chronic inflammatory skin disease ...
Complement-targeting therapies in hemolytic diseases
Volume 98, February 2026, 102686Author links open overlay panel, , Complement inhibition has revolutionized the management...
Local complement inhibition by selective precision-targeted therapies
Volume 98, February 2026, 102687Author links open overlay panel, , , , Excessive complement activation represents a major ...
Regulatory T cell approaches for graft-versus-host disease prevention
Regulatory T cells (Tregs) are a rare subset of T cells that are potent regulators of the immune system. As a result, the ...
The power of genetics in decoding Sjögren’s disease: current status and future development
Volume 98, February 2026, 102690Author links open overlay panel, , Sjögren’s disease (SjD) is the second most common syste...
Indole-3-acetic acid from plants and microbes in human health
In his studies on the response of plants to light and their roots to gravity, Charles Darwin proposed the existence of a s...
Toward indole postbiotics precision therapy via AI-powered drug delivery technologies
Recent advancements in microbiome research have revealed the restorative capacities of postbiotics, including indole and i...
Can we cure autoimmunity?
Volume 98, February 2026, 102684Author links open overlay panel, , , , , , Autoimmune diseases have, until recently, been ...
Friends close, enemies closer: the complex role of the microbiome in antitumor immunity
Immunotherapy has achieved remarkable advances in cancer treatment by harnessing the immune system to combat tumors, yet i...
Metabolism and metabolites regulating hematopoiesis
Energy metabolism of immune cells, such as glycolysis and mitochondrial activity, requires strict regulation. This is espe...
Nucleic acid triggers of autoimmunity and autoinflammation
Volume 93, April 2025, 102535Author links open overlay panel, Highlights•TLR7 and TLR9 play very distinct roles in the dev...
Lymphatic messengers: Non-antigen soluble mediators from diseased tissues to draining lymph nodes
Lymph nodes serve to bring together antigens delivered by afferent lymph originating in draining tissues to meet lymphocyt...
T cell–B cell interactions in human autoimmune diseases
Activation of autoreactive B cells and production of specific autoantibodies are hallmark features of many autoimmune dise...
More X’s, more problems: how contributions from the X chromosomes enhance female predisposition for autoimmunity
Many autoimmune diseases, including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sjogren’s disease (S...
Defenders or defectors: mucosal-associated invariant T cells in autoimmune diseases
Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1, a major histocomp...
Sensory neurons on guard: roles in pathogen defense and host immunity
The ability of a mammalian host to sense and defend against pathogens is essential for survival. Recent studies suggest th...
The choroid plexus: a command center for brain–body communication during inflammation
The choroid plexus (ChP) comprises sheets of secretory epithelial cells enclosing a vascularized stroma of mesenchymal and...
Primary atopic disorders: inborn errors of immunity causing severe allergic disease
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