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Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis
Regulated expression of galectins 1 and 3 IS associated with dysregulated T cell responses in pulmonary and pleural tuberculosis
Galectins exert a wide range of effects on immune cells in acute and chronic pathologies, although their effects are less ...
Therapeutic potential of PMC204 membrane vesicles against drug-resistant
Therapeutic potential of PMC204 membrane vesicles against drug-resistant
Tuberculosis remains a severe global health threat, exacerbated by the rising prevalence of multidrug-resistant (MDR) and ...
A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant
A new bactericidal chlorinated derivative containing 2-aminooxazole potentiates antibacterial action of colistin against multidrug-resistant
This comprehensive study provides insight into the antibacterial action of a recently published 2-chloro-N-(oxazol-2-yl)is...
Diagnostic performance of circulating microRNA signatures for differentiating tuberculosis disease from tuberculosis infection
Diagnostic performance of circulating microRNA signatures for differentiating tuberculosis disease from tuberculosis infection
As regulators of innate and adaptive immunity, microRNAs (miRNAs) could aid in the discrimination between tuberculosis dis...
Effect of controlled human infection on B cell subsets in individuals with different levels of malaria immunity
Effect of controlled human infection on B cell subsets in individuals with different levels of malaria immunity
Continuous exposure to Plasmodium falciparum (Pf) has been associated with alterations in B cells. We investigated the eff...
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
Characterizing tuberculous meningitis in a South African pediatric cohort using GCxGC-TOFMS metabolomics
The objective of this study was to characterize the metabolic profile of tuberculous meningitis (TBM) in the cerebrospinal...
or not? Beyond MALDI-TOF in the frontier of diversity
or not? Beyond MALDI-TOF in the frontier of diversity
Advanced platforms, such as whole genome sequencing (WGS), should be employed to enhance and refine microbial identificati...
Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant while enhancing eubiosis in antibiotic-induced dysbiosis mice
Microbiome therapeutic PMC101 inhibits the translocation of carbapenem-resistant while enhancing eubiosis in antibiotic-induced dysbiosis mice
Carbapenem-resistant Enterobacteriaceae (CRE), known for their extensive antibiotic resistance, pose a severe global medic...
Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages
Furamidine enhances IL-23-mediated autophagic response through IL-23R-TYK2-STAT3-dependent regulation of intracellular Ca²⁺ level to facilitate mycobacterial clearance in human macrophages
Mycobacterium tuberculosis (M. tb), the etiological agent of tuberculosis (TB), subverts host immune responses to establis...
YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine infection
YopP modulates bacterial virulence and systemic dissemination in Peyer´s patches during murine infection
Yersinia enterocolitica (Ye) typically causes gastroenteritis and mesenteric lymphadenitis and can also spread extra-intes...
Commensal induce activation of monocytes via TLR2/CD14 signalling in whole blood
Commensal induce activation of monocytes via TLR2/CD14 signalling in whole blood
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists rega...
Genotypic investigation of in patients with relapsing leprosy in Mato Grosso, Brazil
Genotypic investigation of in patients with relapsing leprosy in Mato Grosso, Brazil
Leprosy is a chronic disease that leads to significant neurological damage and disabilities. Drug resistance is a major ch...
A comprehensive multi-epitope recombinant protein strategy for accurate serological detection of infection
A comprehensive multi-epitope recombinant protein strategy for accurate serological detection of infection
Toxoplasma gondii is a globally prevalent zoonotic parasite responsible for toxoplasmosis. Accurate serological diagnosis ...
The role of ciliary function in airway epithelial defense against
The role of ciliary function in airway epithelial defense against
Respiratory cilia play a crucial role in clearing pathogens from the airway, and understanding how Pseudomonas aeruginosa ...
A novel TamA + LtgC bivalent vaccine induces potent immunogenic and bactericidal antibodies against
A novel TamA + LtgC bivalent vaccine induces potent immunogenic and bactericidal antibodies against
Development of an effective vaccine against Neisseria gonorrhoeae comes with unique challenges. After five decades of rese...
Isohemagglutinins exhibit synergistic polyreactivity toward surface antigens: implications for broad-spectrum reactivity of human antibodies
Isohemagglutinins exhibit synergistic polyreactivity toward surface antigens: implications for broad-spectrum reactivity of human antibodies
Synergistic polyreactivity of antibodies—where distinct oligo- or polyreactive clones combine to enable broad-spectr...
A potent protein vaccines OmpW induces strong protective immunity against in a mouse model
A potent protein vaccines OmpW induces strong protective immunity against in a mouse model
Klebsiella pneumoniae causes severe respiratory-associated infections in healthy individuals, and widespread antibiotic re...
Characterization of outer membrane vesicles from and their role in the dissemination of carbapenem resistance
Characterization of outer membrane vesicles from and their role in the dissemination of carbapenem resistance
Species outside the Acinetobacter calcoaceticus–baumannii (Acb) complex have recently emerged as new clinically rele...
The 2′-α-Fluoro,2′-β-Bromo uridine phosphoramidate prodrug (2-BFU) reduces dengue virus replication and attenuates infection-induced thrombocytopenia
The 2′-α-Fluoro,2′-β-Bromo uridine phosphoramidate prodrug (2-BFU) reduces dengue virus replication and attenuates infection-induced thrombocytopenia
Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febril...
Detection of human antibody responses to tick-borne
Detection of human antibody responses to tick-borne
Tick-borne Neoehrlichia mikurensis is the cause of neoehrlichiosis, an infectious disease that features fever and vascular...
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical pr...
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Exploring the potential of Lactocaseibacillus rhamnosus PMC203 in inducing autophagy to reduce the burden of Mycobacterium tuberculosis
Mycobacterium tuberculosis, a lethal pathogen in human history, causes millions of deaths annually, which demands the deve...
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Identification of homologs of the Chlamydia trachomatis effector CteG reveals a family of Chlamydiaceae type III secreted proteins that can be delivered into host cells
Chlamydiae are a large group of obligate endosymbionts of eukaryotes that includes the Chlamydiaceae family, comprising se...
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Repurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mort...
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases
Carl Flügge is best known for the promotion of studies demonstrating the transmission of all manner of infections, bu...
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Analytical and clinical evaluation of a novel real-time PCR-based detection kit for Mpox virus
Outbreaks of emerging diseases, like Mpox in 2022, pose unprecedented challenges to global healthcare systems. Although Mp...
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus
The Panton-Valentine leukocidin (PVL) of Staphylococcus aureus is associated with necrotizing infections. After binding to...
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV)
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a globally significant vector-borne pathogen with no internationally-lice...
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Trivalent outer membrane vesicles-based combination vaccine candidate induces protective immunity against Campylobacter and invasive non-typhoidal Salmonella in adult mice
Campylobacter and invasive non-typhoidal Salmonella (iNTS) are among the most common causative agents of gastroenteritis w...
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
A plant-based oligomeric CD2v extracellular domain antigen exhibits equivalent immunogenicity to the live attenuated vaccine ASFV-G-∆I177L
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a deadly, highly contagious disease in both ...
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