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Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Seasonal pattern, global search trend, and public interest in arthritis from 2004 to 2022: an infodemiology study
Arthritis is a common condition that causes articular cartilage damage, joint tissue destruction, and ligament involvement...
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort
Patients with idiopathic inflammatory myopathies (IIM) are at increased risk for infections. Identifying clinical and immu...
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Characterization of the neuromuscular manifestations in patients with IgG4-related disease: a systematic review
Immunoglobulin G4-related disease (IgG4-RD) neurological involvement typically presents as pachymeningitis. However, there...
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine protects against postoperative neurocognitive disorder by mitigating mitochondrial dysfunction through regulating the IP3R-GRP75-VDAC1 complex-mediated calcium transport
Dexmedetomidine (Dex), an α2 adrenergic receptor agonist, has been shown to exert protective effects against postoper...
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
History of cold urticaria research: from systematic studies of the 19th century to modern prospective strategies in clinical practice
This study aimed to determine the current prospective strategies for diagnosing and treating cold urticaria based on the h...
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease
The development and stability of induced regulatory T cells (iTregs) are essential for their immunosuppressive function an...
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Lactylation-related multigene signature in multiple myeloma: integrated prognostic stratification, immune landscape profiling, and therapeutic guidance
Multiple myeloma (MM) is an incurable hematologic malignancy with high heterogeneity and poor prognosis. Lactylation, a no...
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF): a Janus-faced cytokine in viral pathogenesis and host defense
Macrophage migration inhibitory factor (MIF) is one of several pivotal cytokines that contribute to orchestrate immune reg...
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
Regulatory dynamics of Th17 lymphocytes in oral squamous cell carcinoma: immune modulation and emerging immunotherapies
With the rapid increase in the severity and mortality of OSCC, the potential for new and effective therapies has increased...
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Polymorphisms in and genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressiv...
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
BECN1 activator peptide Tat-beclin 1 promotes ferroptosis via the BECN1-SLC7A11 axis to inhibit NSCLC progression
Non-small-cell lung cancer (NSCLC) is associated with high mortality. Beclin 1 (BECN1), an autophagy regulator, and ferrop...
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Deciphering macrophage dynamics and immune evasion strategies by the intracellular bacteria
Macrophages are the constituents of the innate immune system that play an important role in the control of infections, pha...
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
MYC affects mitochondrial function in IgA nephropathy by promoting the degradation of MFN1 through HRD1
IgA nephropathy is characterized by the deposition of IgA and complement C3 in the glomerular mesangial region. Recent res...
Hypermethylation of lysosomal-associated genes and compromises lysosome function in patients with acute lymphoblastic leukemia
Hypermethylation of lysosomal-associated genes and compromises lysosome function in patients with acute lymphoblastic leukemia
DNA methylation plays a pivotal role in the pathogenesis of Acute Lymphocytic Leukemia (ALL), a hematological malignancy m...
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges
RNA-based cancer vaccines: mechanisms, clinical progress, and translational challenges
Recent advancements in vaccine technology have led to the development of RNA-based vaccines, including mRNA, circular RNA,...
Prevalence, incidence, and mortality of autoimmune diseases among adolescents and young adults in Mexico: an analysis based on the global burden of disease study 2021
Prevalence, incidence, and mortality of autoimmune diseases among adolescents and young adults in Mexico: an analysis based on the global burden of disease study 2021
This nationwide analysis quantified the contemporary and future burden of six autoimmune diseases (ADs)—rheumatoid a...
Macrophage-derived exosomes in autoimmune diseases: mechanistic insights and therapeutic implications
Macrophage-derived exosomes in autoimmune diseases: mechanistic insights and therapeutic implications
Autoimmune diseases are characterized by an aberrant immune response that targets the body’s own tissues, resulting ...
Efficacy and safety of natural killer cell therapy for the treatment of advanced non-small cell lung cancer: A meta-analysis and systematic review
Efficacy and safety of natural killer cell therapy for the treatment of advanced non-small cell lung cancer: A meta-analysis and systematic review
To evaluate the efficacy and safety of natural killer (NK) cell therapy for the treatment of advanced non-small cell lung ...
Immunoenhancing of the anti-cancer therapy and anti-oxidative stress by co-administration of granulocyte-colony stimulating factor-mobilized stem cells or cells derived from bone marrow and/or spleen plus vaccination with chemotherapeutic cyclophosphamide
Immunoenhancing of the anti-cancer therapy and anti-oxidative stress by co-administration of granulocyte-colony stimulating factor-mobilized stem cells or cells derived from bone marrow and/or spleen plus vaccination with chemotherapeutic cyclophosphamide
The combination of immunotherapy and chemotherapy, referred to as chemo-immunotherapy, represents a promising regimen for ...
Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India
Utility of simultaneous quantification of TREC/KREC in patients with common variable immunodeficiency phenotype: an observational study from North India
Because of its heterogeneity, common variable immunodeficiency (CVID), the commonest symptomatic inborn error of immunity,...
α-Amanitin aggravates hepatic injury by activating oxidative stress and mitophagy via peroxiredoxin 6 inhibition
α-Amanitin aggravates hepatic injury by activating oxidative stress and mitophagy via peroxiredoxin 6 inhibition
Mushroom poisoning is mainly caused by α-amanitin (α-AMA), and there is currently no effective drug to treat ...
Pivotal epitopes for islet antigen-specific CD8 T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele
Pivotal epitopes for islet antigen-specific CD8 T cell detection improve classification of suspected type 1 diabetes with the HLA-A*0201 allele
A proportion of patients with new-onset diabetes share similar symptoms with type 1 diabetes (T1D) patients but they are n...
Phenotypic characterization of tumor associated macrophages and circulating monocytes in patients with Urothelial carcinoma of bladder
Phenotypic characterization of tumor associated macrophages and circulating monocytes in patients with Urothelial carcinoma of bladder
Targeting immune checkpoints has shown clinical efficacy in Urothelial carcinoma of bladder (UBC); however, a substantial ...
Clinical management of autoimmune liver diseases: juncture, opportunities, and challenges ahead
Clinical management of autoimmune liver diseases: juncture, opportunities, and challenges ahead
The three major autoimmune liver diseases are autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary s...
HBx/WDR5 enhances IGF-1 transcription in hepatocellular carcinoma cells and promotes recruitment, infiltration, and activity of Treg cells
HBx/WDR5 enhances IGF-1 transcription in hepatocellular carcinoma cells and promotes recruitment, infiltration, and activity of Treg cells
HBV X protein (HBx), the smallest open reading frame in the hepatitis B virus (HBV) genome, can promote hepatocellular car...
Role of basophils and type 2 inflammation in bullous pemphigoid pathophysiology: a comparative study of blood and blister fluid
Role of basophils and type 2 inflammation in bullous pemphigoid pathophysiology: a comparative study of blood and blister fluid
Bullous pemphigoid (BP) is an autoimmune disease characterized by blister formation and inflammatory cell infiltration. In...
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images
Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images
Accurate and accessible classification of anti-nuclear antibodies (ANA) through indirect immunofluorescence (IIF) imaging ...
Baicalin restores innate lymphoid immune imbalance during exacerbation of COPD
Baicalin restores innate lymphoid immune imbalance during exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is characterized by immune dysregulation, including altered innate lymphoid c...
A patient with variant causing an expression defect in both HLA ABC and HLA DR
A patient with variant causing an expression defect in both HLA ABC and HLA DR
The major histocompatibility complex (MHC) encompasses a group of genes critical for immune system regulation. In humans, ...
Immunomodulatory effects of alexidine dihydrochloride on mammalian macrophages through the modulation of the JNK pathway
Immunomodulatory effects of alexidine dihydrochloride on mammalian macrophages through the modulation of the JNK pathway
A plethora of the cancer drugs with high therapeutic potential cannot pass the clinical trials because of their immunotoxi...
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