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Immune responses against islet allografts during tapering of immunosuppression – A pilot study in 5 subjects
Immune responses against islet allografts during tapering of immunosuppression – A pilot study in 5 subjects
Abstract Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but conti...
Imaging immune responses in neuroinflammatory diseases
Imaging immune responses in neuroinflammatory diseases
Abstract Innate and adaptive immune responses in the central nervous system (CNS) play critical roles in the pathogenesis ...
Decoding the proregenerative competence of regulatory T cells through complex tissue regeneration in zebrafish
Decoding the proregenerative competence of regulatory T cells through complex tissue regeneration in zebrafish
Abstract Regulatory T cells (Tregs) are specific subtype of T cells that play a central role in sustaining self-antigen to...
Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma‐tocotrienol supplementation
Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma‐tocotrienol supplementation
Abstract Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including...
‘A picture is worth a thousand words’: The use of microscopy for imaging neuroinflammation
‘A picture is worth a thousand words’: The use of microscopy for imaging neuroinflammation
Abstract Since the first studies of the nervous system by the Nobel laureates Camillo Golgi and Santiago Ramon y Cajal usi...
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mammalian target of rapamycin signaling pathway in patients with rheumatoid arthritis
Abstract B cell dysfunction and inflammatory cytokine over-production participate in the pathogenesis of rheumatoid arthri...
"A picture is worth a thousand words": the use of microscopy for imaging neuroinflammation
"A picture is worth a thousand words": the use of microscopy for imaging neuroinflammation
Abstract Since the first studies of the nervous system by the Nobel laureates Camillo Golgi and Santiago Ramon y Cajal usi...
Neuroinflammation and immunoregulation in glioblastoma and brain metastases: recent developments in imaging approaches
Neuroinflammation and immunoregulation in glioblastoma and brain metastases: recent developments in imaging approaches
Summary Brain tumors and brain metastases induce changes in brain tissue remodelling that lead to immunosuppression and tr...
Acquired Angioedema in B Cell Lymphoproliferative Disease: A Retrospective Case Series
Acquired Angioedema in B Cell Lymphoproliferative Disease: A Retrospective Case Series
Abstract Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is rare and is associated with underlyin...
Neutrophil‐mediated mechanisms of damage and in vitro protective effect of colchicine in non‐vascular Behçet’s syndrome
Neutrophil‐mediated mechanisms of damage and in vitro protective effect of colchicine in non‐vascular Behçet’s syndrome
Abstract Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations. Neutrophil hyperactiva...
Down‐regulation of PR/SET Domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma
Down‐regulation of PR/SET Domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma
Abstract Hepatocellular carcinoma (HCC) is the world’s leading cause of tumor-related mortalities. Natural killer (...
Intravenous immunoglobulin and the current risk of moderate and severe anaphylactic events, a cohort study
Intravenous immunoglobulin and the current risk of moderate and severe anaphylactic events, a cohort study
Abstract This large cohort study from the US Premier Healthcare Database evaluated the risk and predictors of anaphylaxis ...
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mTOR signaling pathway in patients with rheumatoid arthritis
Altered peripheral B lymphocyte homeostasis and functions mediated by IL‐27 via activating the mTOR signaling pathway in patients with rheumatoid arthritis
Summary B cell dysfunction and inflammatory cytokines over-production participate in the pathogenesis of rheumatoid arthri...
Progressive B cell depletion in human MALT1 deficiency
Progressive B cell depletion in human MALT1 deficiency
Abstract MALT1-deficiency is a rare combined immunodeficiency characterized by recurrent infections, dermatitis and entero...
Cytotoxic T lymphocyte antigen‐4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression
Cytotoxic T lymphocyte antigen‐4 regulates development of xenogenic graft versus host disease in mice via modulation of host immune responses induced by changes in human T cell engraftment and gene expression
Abstract Graft versus host disease (GvHD) is a major clinical problem with a significant unmet medical need. We examined t...
Decoding the Pro‐regenerative Competence of Regulatory T cells (Treg) through Complex Tissue Regeneration in Zebrafish
Decoding the Pro‐regenerative Competence of Regulatory T cells (Treg) through Complex Tissue Regeneration in Zebrafish
Abstract Regulatory T (Treg) cells are specific subtypes of T cells that play a central role in sustaining self-antigen to...
Imaging Immunological Processes from Blood to Brain in Amyotrophic Lateral Sclerosis
Imaging Immunological Processes from Blood to Brain in Amyotrophic Lateral Sclerosis
Abstract Neuropathology studies of amyotrophic lateral sclerosis (ALS) and animal models of ALS reveal a strong associatio...
CTLA‐4 Regulates Development of Xenogenic‐Graft versus Host Disease in Mice via Modulation of Host Immune Responses Induced by Changes in Human T cell Engraftment and Gene Expression
CTLA‐4 Regulates Development of Xenogenic‐Graft versus Host Disease in Mice via Modulation of Host Immune Responses Induced by Changes in Human T cell Engraftment and Gene Expression
ABSTRACT Graft versus Host Disease (GvHD) is a major clinical problem with a significant unmet medical need. We examined t...
PMA Induces the Differentiation of Monocytes into Immunosuppressive MDSCs
PMA Induces the Differentiation of Monocytes into Immunosuppressive MDSCs
Abstract The induction of immune tolerance without the use of immunosuppressive drugs is a crucial problem in organ transp...
Dynamics of circulating dendritic cells and cytokines after kidney transplantation – no effect of remote ischaemic conditioning
Dynamics of circulating dendritic cells and cytokines after kidney transplantation – no effect of remote ischaemic conditioning
Abstract Inflammation resulting from ischaemia/reperfusion injury can cause kidney graft dysfunction, increase the risk of...
Irisin levels in the serum and cerebrospinal fluid of patients with multiple sclerosis and the expression and distribution of irisin in experimental autoimmune encephalomyelitis
Irisin levels in the serum and cerebrospinal fluid of patients with multiple sclerosis and the expression and distribution of irisin in experimental autoimmune encephalomyelitis
Summary Irisin is a novel hormone-like myokine that plays an important role in central nervous system (CNS) diseases, such...
Follicular helper and follicular regulatory T cell subset imbalance is associated with higher activated B cells and abnormal autoantibody production in primary anti‐phospholipid syndrome patients
Follicular helper and follicular regulatory T cell subset imbalance is associated with higher activated B cells and abnormal autoantibody production in primary anti‐phospholipid syndrome patients
Abstract Primary anti-phospholipid antibody syndrome (pAPS) is a multi-organ autoimmune disease, and autoantibodies are in...
T cell activator‐carrying extracellular vesicles induce antigen specific regulatory T cells
T cell activator‐carrying extracellular vesicles induce antigen specific regulatory T cells
Abstract he mechanism of antigen (Ag)-specific regulatory T cell (Treg) induction is not fully understood yet. Curcumin ha...
Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma‐tocotrienol supplementa
Reduced infiltration of regulatory T cells in tumours from mice fed daily with gamma‐tocotrienol supplementa
Abstract Gamma-tocotrienol (γT3) is an analogue of vitamin E with beneficial effects on the immune system, including...
55 years in the life of Clinical & Experimental Immunology
55 years in the life of Clinical & Experimental Immunology
Launched in 1966 by the British Society for Immunology, Clinical & Experimental Immunology (CEI) is this year celebrat...
Towards PET imaging of the dynamic phenotypes of microglia
Towards PET imaging of the dynamic phenotypes of microglia
Abstract There is increasing evidence showing the heterogeneity of microglia activation in neuroinflammatory and neurodege...
Improved function and balance in T cell modulation by endothelial cells in young people
Improved function and balance in T cell modulation by endothelial cells in young people
Abstract Elderly individuals exhibit unbalanced bone marrow (BM) effector T cell subset differentiation, such as increased...
Inflammatory cytokine responses in children with asymptomatic malaria infection living in rural, semi‐urban and urban areas in south‐eastern Gabon
Inflammatory cytokine responses in children with asymptomatic malaria infection living in rural, semi‐urban and urban areas in south‐eastern Gabon
Abstract Cytokines are soluble mediators of the immune response and their evolution influences the disease outcome. Gainin...
Body mass index and adipokines/cytokines dysregulation in Systemic Sclerosis
Body mass index and adipokines/cytokines dysregulation in Systemic Sclerosis
ABSTRACT Body fat has regulatory functions through producing cytokines and adipokines whose role in the pathogenesis of Sy...
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