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HIV-induced T cell quiescence and the origins of viral latency
HIV-induced T cell quiescence and the origins of viral latency
HIV drives host cells into dormancy within days of infection, actively laying the groundwork for latency and long-term per...
Macrophages drive fat cell differentiation
Adipose tissue macrophages are found in anatomically distinct subtissular niches, but how different macrophage subsets con...
Evading tumor evasion
Tumors often generate acidic microenvironments that are hostile to immune cells and impede anti-tumor immune responses. In...
Effector-memory ILC2s
In the small intestine, chemosensory tuft cells sense parasitic helminths and release IL-25 to activate resident type 2 in...
Sensory nerve niches
Macrophages associated with the peripheral nervous system are incompletely understood. In Immunity, Henneke and colleagues...
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections
Plasmacytoid dendritic cells (pDCs) are major producers of type I/III interferons. As interferons are crucial for antivira...
Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease
Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease
Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney diseases and is characteri...
Human versus mouse PD-1
Engagement of the immune checkpoint receptor PD-1 by its ligand PD-L1 triggers recruitment and activation of the phosphata...
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer
Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existen...
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation
Regulatory T (Treg) cells are a specialized CD4+ T cell lineage with essential anti-inflammatory functions. Analysis...
Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
These authors contributed equally: Nargis Khan, Kim A. Tran.Department of Medicine, Department of Pathology, Department of...
Insights into autoimmunity and cancer
Insights into autoimmunity and cancer
In December 2024, the NIH Office of Autoimmune Disease Research in the Office of Research on Women’s Health (OADR-OR...
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Metabolite signaling promotes the recruitment of immunosuppressive cells to tumors
Metabolite-sensing G protein-coupled receptors act as critical signaling hubs that connect metabolism to immunity in cance...
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
The NLRP3 inflammasome is a multiprotein complex that mediates caspase-1 activation and the release of proinflammatory cyt...
Systems neuroimmunology: current bottlenecks, research priorities and future directions
Systems neuroimmunology: current bottlenecks, research priorities and future directions
Strategies to advance the field of neuroimmunology by embracing its complexity via inclusion of its multidisciplinary prop...
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation
The nature of activation signals is essential in determining T cell subset differentiation; however, the features that det...
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require ...
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function
Spleen marginal zone (MZ) B cells are important for antibody responses against blood-borne antigens. The signals they use ...
Publisher Correction: CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
John DaviesPresent address: Department of Safety Assessment, Genentech, Inc., San Francisco, CA, USAChristian S. HinrichsP...
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Repeated mRNA vaccination sequentially boosts SARS-CoV-2-specific CD8+ T cells in persons with previous COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hybrid immunity is more protective than vaccination or previo...
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance
Bacille Calmette–Guérin (BCG) vaccination can confer nonspecific protection against heterologous pathogens. How...
Author Correction: Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms
Author notesWen ZhouPresent address: BillionToOne, Menlo Park, CA, USAFan GaoPresent address: Lyterian Therapeutics, South...
Severe dengue progression beyond enhancement
Severe dengue progression beyond enhancement
The immune response to dengue virus infection is a well-coordinated balancing act. New research shows that an imbalanced r...
Cancer immunology leads the way
Cancer immunology research is diverse, uses cutting-edge technologies and continues to excite with its constantly evolving...
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen re...
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consumin...
A second-generation M1-polarized CAR macrophage with antitumor efficacy
A second-generation M1-polarized CAR macrophage with antitumor efficacy
Chimeric antigen receptor (CAR) T cell therapies have successfully treated hematological malignancies. Macrophages have al...
The immunometabolic ecosystem in cancer
The immunometabolic ecosystem in cancer
Our increased understanding of how key metabolic pathways are activated and regulated in malignant cells has identified me...
Forks in the road for CAR T and CAR NK cell cancer therapies
Forks in the road for CAR T and CAR NK cell cancer therapies
The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented long-term clearance of relapse/...
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin
Lymphocyte development consists of sequential and mutually exclusive cell states of proliferative selection and antigen re...
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