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Tumor resection may abort the antitumor immune response produced from primary foci
Surgical resection represents a cornerstone of cancer treatment. However, clinical observations indicate that tumor recurr...
Clarifying diagnostic rigor and cohort characteristics in neurosyphilis nomogram development: a response to Kenyon
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Thymidine induces macrophage M1 polarization in radiation-induced-lung-injury by ATF3/p38 pathway
Radiation-induced lung injury (RILI) is a common complication associated with thoracic radiotherapy for malignant tumors s...
Identification and validation of hub genes associated with neutrophil immunosuppression during Sepsis
Sepsis, a life-threatening syndrome arising from a dysregulated host response to infection, remains a leading cause of mor...
STAT signaling pathway in pregnancy stages and related to complications
Pregnancy is often viewed as a semi-allograft situation because the fetus carries paternal antigens, which can create an i...
FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway
Stroke is clinically defined as an acute-onset neurological dysfunction caused by disrupted cerebral perfusion. It ranks a...
Aerobic exercise activates let-7e-5p through TP73-AS1 to inhibit the HMGB1/RAGE axis and alleviate asthma airway inflammation and remodeling
Asthma has emerged as the most widespread chronic condition in developed nations, impacting more than 10 % of the adult po...
“Mesenchymal stem cell-derived exosomes (MSC-exosomes) in hematology: From mechanisms to clinical breakthroughs”
Mesenchymal stem cells, commonly referred to as MSCs, represent a distinct category of multipotent stromal cells that poss...
Macrophage heterogeneity in autoimmune diseases
Autoimmune diseases are a group of disorders characterized by an aberrant immune response, in which the immune system erro...
Gliadin amplifies the macrophage response triggered by stressed beta cells
In humans, a gluten-free diet can slow disease progression and improve clinical outcome in newly diagnosed type 1 diabetes...
Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis
Systemic erythematosus lupus (SLE) is a chronic autoimmune disease in which the immune system attacks healthy cells and ti...
MEX3A activates the JAK-STAT pathway to suppress NK cell cytotoxicity and accelerate lung adenocarcinoma progression
LUAD, the most frequent subtype of lung cancer, represents about 40 % of all lung cancer cases [1]. Despite the recent str...
Quercetin alleviates diabetic nephropathy by inhibiting M1 macrophage polarization via targeting NLRC5/NLRP3 pathway
Diabetic nephropathy (DN) constitutes one of the gravest microvascular complications of diabetes mellitus (DM) and stands ...
Functional avidity enhancement of a T-cell receptor targeting the KRASG12D cancer neoantigen
Somatic mutations can generate neoantigens that are exclusive to cancer cells and absent in normal tissues, making them at...
Acetyl-CoA subcellular compartmentalization regulates T cell adaptation
Upon activation, naïve T cells undergo rapid proliferation and differentiation, giving rise to clonally expanded populatio...
ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis
Acute lung injury (ALI) is a respiratory disease that widely exists in the world and can develop into severe respiratory f...
Enhancing the antitumor activity of CD19/BCMA CAR-T cells in vitro with a PD1IL7R chimeric switch receptor
CAR-T cell immunotherapy is an adoptive cell therapy that involves the genetic modification of a patient's T lymphocytes, ...
Sfrp2-deficient colonic fibroblasts drive mucosal inflammation and epithelial injury in ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder targeting the colon with an increasing global prevalence. The d...
Chloroquine treatment ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell differentiation and pDC accumulation
ObjectivesChloroquine (CQ) has been used to treat rheumatoid arthritis and systemic lupus erythematosus, but its use in mu...
METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells
Natural killer (NK) cells, as innate cytotoxic lymphocytes, serve as the first line of defense against infections and tumo...