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SCI Abstract
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Corrigendum to “BCG and β-glucan primed monocytes yield dendritic cells that hamper the induction of pro-inflammatory T cell immunity” [Cell. Immunol. 419 (2026) 105060]
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Tumor resection may abort the antitumor immune response produced from primary foci
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Clarifying diagnostic rigor and cohort characteristics in neurosyphilis nomogram development: a response to Kenyon
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Thymidine induces macrophage M1 polarization in radiation-induced-lung-injury by ATF3/p38 pathway
Radiation-induced lung injury (RILI) is a common complication associated with thoracic radiotherapy for malignant tumors s...
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Identification and validation of hub genes associated with neutrophil immunosuppression during Sepsis
Sepsis, a life-threatening syndrome arising from a dysregulated host response to infection, remains a leading cause of mor...
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Dendritic cells targeted CEA tumor antigen through DEC205 in combination with oncolytic reovirus stimulate strong immune response in colorectal cancer model
Colorectal cancer (CRC) is one of the most common cancers in the world and ranks third in terms of incidence, but second i...
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STAT signaling pathway in pregnancy stages and related to complications
Pregnancy is often viewed as a semi-allograft situation because the fetus carries paternal antigens, which can create an i...
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FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway
Stroke is clinically defined as an acute-onset neurological dysfunction caused by disrupted cerebral perfusion. It ranks a...
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The RNA-binding protein ALYREF promotes mitochondrial dysfunction and ferroptosis in CD4+ helper T cells in chronic obstructive pulmonary disease and non-small cell lung cancer by enhancing ZWINT mRNA stability
Worldwide, lung cancer leads in cancer-related deaths, with non-small cell lung cancer (NSCLC) comprising approximately 85...
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Aerobic exercise activates let-7e-5p through TP73-AS1 to inhibit the HMGB1/RAGE axis and alleviate asthma airway inflammation and remodeling
Asthma has emerged as the most widespread chronic condition in developed nations, impacting more than 10 % of the adult po...
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“Mesenchymal stem cell-derived exosomes (MSC-exosomes) in hematology: From mechanisms to clinical breakthroughs”
Mesenchymal stem cells, commonly referred to as MSCs, represent a distinct category of multipotent stromal cells that poss...
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Macrophage heterogeneity in autoimmune diseases
Autoimmune diseases are a group of disorders characterized by an aberrant immune response, in which the immune system erro...
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Polymorphonuclear myeloid-derived suppressor cells protect against hyperoxia-induced bronchopulmonary dysplasia in neonatal mice through suppression of excessive inflammatory response
Advancements in neonatology over the past few decades have considerably increased the survival rate of premature newborns ...
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A novel approach to hematopoietic stem cell transplantation: The effect of CMV infection and HLA genotypes on chimerism status in Egyptian patients
Over the past three decades, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for patient...
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Gliadin amplifies the macrophage response triggered by stressed beta cells
In humans, a gluten-free diet can slow disease progression and improve clinical outcome in newly diagnosed type 1 diabetes...
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Curcumin mitigates systemic lupus erythematosus by suppressing double-negative T cells through cell apoptosis
Systemic erythematosus lupus (SLE) is a chronic autoimmune disease in which the immune system attacks healthy cells and ti...
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MEX3A activates the JAK-STAT pathway to suppress NK cell cytotoxicity and accelerate lung adenocarcinoma progression
LUAD, the most frequent subtype of lung cancer, represents about 40 % of all lung cancer cases [1]. Despite the recent str...
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Efficacy and safety of interferon alpha-2b aerosol therapy for patients infected with the SARS-CoV-2 omicron variant: A randomized controlled single-blind study
Despite widespread vaccination, COVID-19 continues to pose a global public health threat. Current treatment strategies pri...
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Quercetin alleviates diabetic nephropathy by inhibiting M1 macrophage polarization via targeting NLRC5/NLRP3 pathway
Diabetic nephropathy (DN) constitutes one of the gravest microvascular complications of diabetes mellitus (DM) and stands ...
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M6A methyltransferase ZC3H13-mediated downregulation of GPX4 mRNA stability inhibits the progression of kidney renal clear cell carcinoma (KIRC)
As a common malignancy in the urinary system, renal cell carcinoma (RCC) originates from the renal epithelium and accounts...
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Functional avidity enhancement of a T-cell receptor targeting the KRASG12D cancer neoantigen
Somatic mutations can generate neoantigens that are exclusive to cancer cells and absent in normal tissues, making them at...
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Acetyl-CoA subcellular compartmentalization regulates T cell adaptation
Upon activation, naïve T cells undergo rapid proliferation and differentiation, giving rise to clonally expanded populatio...
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Corrigendum to “Modular activation of macrophage-like cells by beta-2-microglobulin via mitochondria and the cGAS-STING pathway” [Cell. Immunol. 413 (2025) 104962]
Volume 414, August 2025, 104984Author links open overlay panelJosefine Kofoed Corneliussen a, Helena Borland Madsen b, Nad...
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ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis
Acute lung injury (ALI) is a respiratory disease that widely exists in the world and can develop into severe respiratory f...
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Enhancing the antitumor activity of CD19/BCMA CAR-T cells in vitro with a PD1IL7R chimeric switch receptor
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Sfrp2-deficient colonic fibroblasts drive mucosal inflammation and epithelial injury in ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder targeting the colon with an increasing global prevalence. The d...
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Chloroquine treatment ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell differentiation and pDC accumulation
ObjectivesChloroquine (CQ) has been used to treat rheumatoid arthritis and systemic lupus erythematosus, but its use in mu...
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Identification of Epstein-Barr virus nuclear antigen 1 (EBNA1)-specific T-cell receptors: implications for immunotherapy targeting EBV-associated malignancies
Epstein-Barr virus (EBV), an oncogenic γ-herpes virus infecting >90 % of adults worldwide, is associated with malignanc...
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METTL3 positively regulates the development and cytotoxicity of human embryonic stem cells-derived NK cells
Natural killer (NK) cells, as innate cytotoxic lymphocytes, serve as the first line of defense against infections and tumo...
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KLHDC8A knockdown in normal ovarian epithelial cells promoted the polarization of pro-tumoral macrophages via the C5a/C5aR/p65 NFκB signaling pathway
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