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Fisetinidin chloride ameliorates carbon tetrachloride-induced hepatotoxicity in HepaRG cells
Fisetinidin chloride ameliorates carbon tetrachloride-induced hepatotoxicity in HepaRG cells
Liver diseases poses a significant global health burden. This study investigated the hepatoprotective effects of fisetinid...
Integrated analysis of RNA-binding proteins in MAFLD: mechanistic insights and diagnostic biomarker potential via alternative splicing
Integrated analysis of RNA-binding proteins in MAFLD: mechanistic insights and diagnostic biomarker potential via alternative splicing
Metabolic associated fatty liver disease (MAFLD) is a highly prevalent global chronic liver disease. While abnormal expres...
EMF-induced mesenchymal stem cell migration is mediated by SOCE-dependent calcium influx and modulated by ROCK signaling
EMF-induced mesenchymal stem cell migration is mediated by SOCE-dependent calcium influx and modulated by ROCK signaling
Electromagnetic field (EMF) exposure promotes mesenchymal stem cell (MSCs) migration, a critical process in regenerative m...
Shionone attenuates endoplasmic reticulum stress-associated ferroptosis in cardiomyocytes by reducing LCN2 and regulating PI3K/Akt signaling
Shionone attenuates endoplasmic reticulum stress-associated ferroptosis in cardiomyocytes by reducing LCN2 and regulating PI3K/Akt signaling
Ischemia/reperfusion-induced myocardial dysfunction remains a clinical problem and is associated to poor outcomes in patie...
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells
ALK5 inhibition reduces HDM-induced inflammation and oxidative injury by regulating KLF4-mediated glycolysis in BEAS-2B cells
As an important transcription factor, activin receptor-like kinase 5 (ALK5) plays a crucial role in the development of var...
PTGS2 as a potential target for apigenin to promote spinal cord injury repair
PTGS2 as a potential target for apigenin to promote spinal cord injury repair
Spinal cord injury (SCI) is characterized by damage to the spinal cord caused by various reasons, and there is a lack of e...
P2 X 7 receptor deficiency ameliorates high-fat-induced cardiac remodeling by improving oxidative stress through PI3K/AKT/GSK3β-mediated regulation of Nrf2
P2 X 7 receptor deficiency ameliorates high-fat-induced cardiac remodeling by improving oxidative stress through PI3K/AKT/GSK3β-mediated regulation of Nrf2
Abnormal or excessive fat accumulation may lead to the development of cardiac remodeling. Yet, the mechanism of action rem...
Mesenchymal stem cell-originated exosomal ZEB1 alleviates hypoxia/reperfusion-induced apoptosis, oxidative stress, and endoplasmic reticulum stress in cardiomyocytes via regulating UBIAD1
Mesenchymal stem cell-originated exosomal ZEB1 alleviates hypoxia/reperfusion-induced apoptosis, oxidative stress, and endoplasmic reticulum stress in cardiomyocytes via regulating UBIAD1
Background: Acute myocardial infarction (AMI) is a major cardiovascular disease. Exosomes from mesenchymal stem cells (MSC...
MATR3 regulates METTL3-Mediated mA modification of MSI2 mRNA to activate the Wnt/β-Catenin pathway, exacerbating myocardial fibrosis and atrial fibrillation
MATR3 regulates METTL3-Mediated mA modification of MSI2 mRNA to activate the Wnt/β-Catenin pathway, exacerbating myocardial fibrosis and atrial fibrillation
To investigate the role and molecular mechanisms of the RNA-binding protein MATR3 in myocardial fibrosis of atrial fibrill...
Unraveling the therapeutic mechanisms of cinnamaldehyde in allergic rhinitis: a network Pharmacology and experimental approach
Unraveling the therapeutic mechanisms of cinnamaldehyde in allergic rhinitis: a network Pharmacology and experimental approach
Cinnamaldehyde (CA), a bioactive compound with demonstrated anti-inflammatory and anti-oxidant properties, has been shown ...
The eIF3a/m6A/ENO1 axis orchestrates glycolytic reprogramming and cell growth in cervical cancer
The eIF3a/m6A/ENO1 axis orchestrates glycolytic reprogramming and cell growth in cervical cancer
Glycolysis plays a key role in the development of cervical cancer (CC); therefore, investigating its molecular mechanisms ...
METTL16-mediated m6A modification of LYRM2 drives breast cancer progression by inducing CD8 T cell dysfunction via Glycolysis
METTL16-mediated m6A modification of LYRM2 drives breast cancer progression by inducing CD8 T cell dysfunction via Glycolysis
CD8+ T cells in the tumor microenvironment suppress breast cancer (BRCA) progression. Although LYRM2 correlates with immun...
Efficacy of 5-fluorouracil and metronomic chemotherapy mediated ornithine decarboxylase antizyme for inhibiting of colorectal cancer
Efficacy of 5-fluorouracil and metronomic chemotherapy mediated ornithine decarboxylase antizyme for inhibiting of colorectal cancer
the inhibitory therapy for colorectal cancer (CRC) is currently a hot topic in clinical research, and the stability betwee...
Coenzyme Q10 exerts anti-cancer effects in bladder cancer by inducing ROS-mediated apoptosis and autophagy
Coenzyme Q10 exerts anti-cancer effects in bladder cancer by inducing ROS-mediated apoptosis and autophagy
Bladder cancer (BCa) is one of the most common types of cancer that impacts the urinary system, and its incidence is incre...
Ferulic acid relieves hypoxic damage by inhibiting endoplasmic reticulum stress, oxidative stress, and apoptosis through activating FOXA2-modulated Nrf2/HO-1 pathway in spermatogonial cells
Ferulic acid relieves hypoxic damage by inhibiting endoplasmic reticulum stress, oxidative stress, and apoptosis through activating FOXA2-modulated Nrf2/HO-1 pathway in spermatogonial cells
Male infertility is a global public health problem affecting human development. Ferulic acid (FA) is an important active p...
Epigenetic activation of PDLIM7 via H3K27 acetylation mitigates neuroinflammation and neurodegeneration in parkinson’s disease models
Epigenetic activation of PDLIM7 via H3K27 acetylation mitigates neuroinflammation and neurodegeneration in parkinson’s disease models
This study investigates the role and regulatory mechanisms of PDZ and LIM domain protein 7 (PDLIM7) in the pathology of Pa...
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via based on transcriptome sequencing analysis
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via based on transcriptome sequencing analysis
The incidence of knee osteoarthritis (KOA) continues to rise with the aging of the population, which seriously reduces the...
DNA hypermethylation drives BVES-mediated autophagy to promote cisplatin resistance in lung adenocarcinoma
DNA hypermethylation drives BVES-mediated autophagy to promote cisplatin resistance in lung adenocarcinoma
Aberrant DNA methylation induces abnormal expression of drug-resistance genes, promoting drug resistance. This study ident...
The expression of glial cell-derived neurotrophic factor in the hippocampal tissue of rats with vascular dementia and its correlation with molecular pathways involved in learning and memory impairment
The expression of glial cell-derived neurotrophic factor in the hippocampal tissue of rats with vascular dementia and its correlation with molecular pathways involved in learning and memory impairment
It aimed to investigate the expression of glial cell-derived neurotrophic factor (GDNF) in the hippocampal tissue of rats ...
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen-glucose deprivation/reperfusion-induced brain damage PINK1/Parkin pathway activation
Accumulating studies have unraveled that dexmedetomidine (DEX) is neuroprotective against brain damage. However, it remain...
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Anti-inflammatory effects of Esomeprazole in septic lung injury by mediating endoplasmic reticulum stress
Acute lung injury characterized by overactive pulmonary inflammation is a common and serious complication of sepsis. Esome...
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Targeting hypoxia-induced HIF-1α/JMJD3/Notch axis in gastric cancer therapy
Hypoxia has been reported to induce high expression of HIF-1α in multiple cancer tissues, and HIF-1α significant...
KunMingShanHaiTang formula reprograms macrophage metabolism and promotes M2 polarization via the HIF-1α pathway to alleviate ulcerative colitis symptoms in a rat model
KunMingShanHaiTang formula reprograms macrophage metabolism and promotes M2 polarization via the HIF-1α pathway to alleviate ulcerative colitis symptoms in a rat model
The KunMingShanHaiTang Formula (KMSHTF), adjusted by Professor Zhong Chuanhua for the treatment of ulcerative colitis (UC)...
The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer
The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer
Otto Warburg originally proposed that cancer arose from a two-step process. The first step involved a chronic insufficienc...
Mechanism of LncRNA CBR3-AS1 in regulating pyroptosis of intestinal epithelial cells in ulcerative colitis
Mechanism of LncRNA CBR3-AS1 in regulating pyroptosis of intestinal epithelial cells in ulcerative colitis
Ulcerative colitis (UC) is a common chronic relapsing inflammatory disease that threatens human life. This study aims to e...
Differences in metabolite profiling by cold atmospheric plasma in normal and cancer cells
Differences in metabolite profiling by cold atmospheric plasma in normal and cancer cells
Cold atmospheric plasma (CAP) recently it has been introduced as an innovative therapeutic approach for cancer cell treatm...
NSUN2 contributes to the RB malignant progression and Glycolysis by mediating the m5C methylation modification of HKDC1
NSUN2 contributes to the RB malignant progression and Glycolysis by mediating the m5C methylation modification of HKDC1
Retinoblastoma (RB) is a malignant neoplasm originating from photoreceptor precursor cells that is common in children unde...
Mollugin attenuates oxygen-glucose deprivation/reperfusion-induced brain microvascular endothelial cell death and permeability through activation of BDNF/TrkB-modulated Akt pathway
Mollugin attenuates oxygen-glucose deprivation/reperfusion-induced brain microvascular endothelial cell death and permeability through activation of BDNF/TrkB-modulated Akt pathway
Brain microvascular endothelial cell injury is an important pathological basis for blood-brain barrier damage in ischemic ...
TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression
TKT regulates the pentose phosphate pathway via RBKS to promote epithelial-mesenchymal transition during AML progression
Acute myeloid leukemia is a life-threaten disease. Researches have indicated that increased expression of TKT was closely ...
Dimethyl fumarate improves sepsis-induced acute lung injury by inhibiting STING-mediated ferroptosis
Dimethyl fumarate improves sepsis-induced acute lung injury by inhibiting STING-mediated ferroptosis
The precise pathogenic mechanisms underlying sepsis-induced acute respiratory distress syndrome (ARDS) remain incompletely...
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