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Controlling cell architecture with protein design
Cells depend on a complex and precisely regulated subcellular organization, largely driven by the cytoskeleton and motor p...
Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity
The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (NaV)...
Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms
Cell biologists use a severely undersampled population of eukaryotes as model organisms to infer cellular processes across...
KASH proteins transform from passive tethers to dynamic conductors of motor-driven nuclear dynamics
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality control
Misfolded proteins can be toxic to cells, and their accumulation is a hallmark of diseases such as neurodegeneration. Norm...
Signaling mechanisms in the reactivation of quiescent neural stem cells in Drosophila
Neural stem cells (NSCs) play a central role in the nervous system development and regeneration. In the adult mammalian br...
Cancer-associated fibroblasts as mediators of tissue microenvironment remodeling in cancer
Cancer-associated fibroblasts (CAFs) are a multifunctional cell population of solid tumors that substantially remodel the ...
Mechanisms of cellular fitness and cell competition: Towards an integrated view
Cell competition is a fundamental mechanism of tissue quality control that enables the selective elimination of less fit, ...
Epigenetic regulation of DUX4: From embryogenesis to muscular degeneration
DUX4 is a transcription factor with a critical role in zygotic genome activation. It is expressed briefly in early embryog...
When two worlds collide: actin dynamics on endomembranes regulates membrane trafficking
Membrane trafficking is an essential aspect of cellular physiology, determining the spatial distribution of macromolecules...
Cell signaling across scales in health and disease
Victoria Sanz Moreno is a Professor of Cancer Cell and Metastasis Biology at the Institute of Cancer Research in London. H...
Roles of molecular motors in insulin-secreting beta cells
Pancreatic β cells are essential for glucose homeostasis through the regulated secretion of insulin in response to rising ...
Modeling cytoskeletal and cell dynamics
Here we give an overview of recent theoretical and experimental work on modeling the mechanics and dynamics of the cytoske...
Dynamic regulation of cell death signaling
There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from com...
From images to understanding: Advances in deep learning for cellular dynamics analysis
Deep learning (DL) has revolutionized bioimage analysis, enabling unprecedented insights into cellular dynamics. This revi...
Actin cytoskeleton protection by the formin-mediated safety valve
Mechanical forces shape cellular form and function by regulating key cellular processes; however, when dysregulated, they ...
Single-molecule biophysics in signaling: Functionality from stochastic effects
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
New insights into signaling networks coordinating epidermal stem cell regulation in skin regeneration and aging
The skin is a dynamic, regenerative organ capable of withstanding diverse internal and external stresses, supported by tis...
Autophagy regulation by signaling
The first identified regulators of autophagy were the hormones Glucagon and Insulin, long before the recognition that they...
Lessons on the force-form-function connection in cell biology from modeling a syncytial germline
Germline architecture plays a critical role in the production of functional gametes. Across species, oogenesis involves no...
The unconventional role of vimentin intermediate filaments
Intermediate filament (IF) proteins are essential components of the cytoskeleton, and are classified into six types based ...
The recent advances and implications in cancer therapy for the hippo pathway
Proper organ development and size control require an intricate balance between cell proliferation and apoptosis in additio...
Autophagic flux measurement: Cargo degradation versus generation of degradation products
Autophagy is the cellular processes that transport cytoplasmic components to lysosomes for degradation. It plays essential...
Moving the fat: Emerging roles of rab GTPases in the regulation of lipid droplet contact sites
Lipid droplets (LDs) play crucial roles in lipid metabolism, energy homeostasis, and cellular stress. Throughout their lif...
Unconventional protein secretion: Exploring membrane proteins and beyond
Protein secretion is essential for cellular communication and function, enabling the delivery of both soluble and integral...
Organelle homeostasis requires ESCRTs
The endosomal sorting complexes required for transport (ESCRT) catalyze membrane shape transformations throughout the cell...
LRRK2, lysosome damage, and Parkinson's disease
Limited understanding of regulatory mechanisms controlling LRRK2 kinase activity has hindered insights into both its norma...
Centrosome biogenesis and maintenance in homeostasis and disease
The centrosome was first described in the late 19th century, independently by Theodor Boveri and Edouard Van Beneden, who ...
The functional organisation of the centromere and kinetochore during meiosis
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Aneuploidy as a cancer vulnerability
Aneuploidy is defined as uneven sets of chromosomes in cells, that is chromosome numbers that deviate from the exact multi...
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