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Adipose-Derived Proinflammatory Visfatin Promotes Vascular Calcification via TLR4 and is Suppressed by Empagliflozin
Adipose-Derived Proinflammatory Visfatin Promotes Vascular Calcification via TLR4 and is Suppressed by Empagliflozin
Vascular calcification, a common complication of metabolic diseases such as diabetes and obesity, is closely associated wi...
Dendritic Cells Derived MMP9 Fuels Sepsis-Induced Cardiac Dysfunction Through JNK/AP1 Driven Pro-Inflammatory Cytokine and Nitric Oxide Storm
Dendritic Cells Derived MMP9 Fuels Sepsis-Induced Cardiac Dysfunction Through JNK/AP1 Driven Pro-Inflammatory Cytokine and Nitric Oxide Storm
Metalloproteinase9 is an important inflammatory mediator, but its contribution to sepsis-induced myocardial dysfunction (S...
The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions
The Histamine Four Receptor Regulates LFA-1 But Not Mac-1 -Dependent Neutrophil Adhesion and Inflammatory Functions
Neutrophils incubated on ICAM-1- or fibrinogen- coated plates produced histamine in response to fMLP indicating that hista...
Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis
Peripheral Circulating Exosomes Induce Sepsis-associated Liver Injury by Up-regulating STAT1 to Promote Autophagy and Regulating the SLC7A11-GSH-GPX4 Axis to Promote Ferroptosis
Peripheral exosomes have been implicated in the pathogenesis of multiple organ dysfunction during sepsis. However, their r...
Nrf2 Protects Against Lipoteichoic Acid-Induced Acute Lung Injury By Suppressing SLC24A2-Mediated Ferroptosis
Nrf2 Protects Against Lipoteichoic Acid-Induced Acute Lung Injury By Suppressing SLC24A2-Mediated Ferroptosis
Acute lung injury (ALI) is a severe inflammatory syndrome characterized by epithelial and endothelial injury, increased pu...
Erosion or Explosion: Integrated Single-Cell Transcriptomics Reveals Cellular Heterogeneity in Aortic Aneurysm and Dissection
Erosion or Explosion: Integrated Single-Cell Transcriptomics Reveals Cellular Heterogeneity in Aortic Aneurysm and Dissection
Aortic aneurysm (AA) and aortic dissection (AD) are life-threatening vascular diseases characterized by progressive wall d...
miR-182-Mediated Dysregulation of Histidine Metabolism Compromises T Cell Immunity in Sepsis
miR-182-Mediated Dysregulation of Histidine Metabolism Compromises T Cell Immunity in Sepsis
MicroRNA-182 (miR-182) exhibits immunomodulatory effects in regulating inflammatory responses to bacterial infection. Howe...
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP
C-reactive protein (CRP) is a highly conserved pentraxin, synthesized primarily in the liver, and is widely recognized as ...
HAPLN1 Exhibits Dual Effects: Facilitating Extracellular Matrix Restoration while Enhancing Inflammatory Mediator Production in Arthritic Chondrocytes
HAPLN1 Exhibits Dual Effects: Facilitating Extracellular Matrix Restoration while Enhancing Inflammatory Mediator Production in Arthritic Chondrocytes
Hyaluronan and proteoglycan link protein 1 (HAPLN1) secreted by fibroblast-like synoviocytes (FLSs) plays a critical role ...
The Kynurenine Pathway in Psoriasis: Mechanisms and Therapeutic Opportunities
The Kynurenine Pathway in Psoriasis: Mechanisms and Therapeutic Opportunities
Psoriasis is a chronic inflammatory disease driven by genetic and environmental factors, with pathogenesis closely linked ...
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice
Ferroptosis is closely associated with the various pathological manifestations of asthma. This study aimed to explore the ...
Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil Elastase
Neutrophils Induce P-Selectin Shedding from Activated Platelets Via Neutrophil Elastase
It is suggested that neutrophil adhesion to P-selectin (P-sel) on activated platelet can induce P-sel shedding, however, t...
The Role of CCL11-CCR3 Induced Mitochondrial Dysfunction and Oxidative Stress in Cognitive Impairment in Early-onset Schizophrenia: Insights from Preclinical Studies
The Role of CCL11-CCR3 Induced Mitochondrial Dysfunction and Oxidative Stress in Cognitive Impairment in Early-onset Schizophrenia: Insights from Preclinical Studies
Abnormal cytokine expression has been implicated as a potential contributor to neurodegeneration. This study aimed to inve...
Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium
Large Peritoneal Macrophages Promote the Resolution of Inflammation in Injured Endometrium
Macrophages play a significant role in the repair of endometrial injuries. While large peritoneal macrophages (LPMs) have ...
Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M
Exposure to Dietary Nitrite Exacerbates Lupus in MRL/lpr Mice by Enhancing Integrin Alpha M
There is a recognized longitudinal association between serum nitrogen oxides levels and disease activity in lupus nephriti...
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of
Mutations in the WFS1 gene, encoding wolframin (WFS1), are known to cause endoplasmic reticulum (ER) stress and lead to Wo...
Inflammatory Association between Periodontal Disease and Systemic Health
Inflammatory Association between Periodontal Disease and Systemic Health
Periodontitis is an oral disease that affects almost half of the adult population in United States. The complex relationsh...
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4
Membrane-Associated RING-CH-Type Finger 6 Protects against Hypertension-Induced Cardiac Remodeling by Suppressing Cardiomyocyte Ferroptosis Through the Degradation of ACSL4
Hypertension serves as a major contributing factor to various cardiovascular disorders, including heart failure. Ferroptos...
Inactivated R0179 Inhibits -Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis
Inactivated R0179 Inhibits -Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis
This study aims to explore the mechanism by which heat-inactivated Bacillus subtilis (B. subtilis) R0179 modulates the TLR...
Neutrophil Heterogeneity in Airway Inflammatory Diseases
Neutrophil Heterogeneity in Airway Inflammatory Diseases
Neutrophils, the most abundant circulating leukocytes in humans, play key roles in infection and inflammation. The lungs r...
Chemerin Exacerbates Pulmonary Inflammation in Type 2 Diabetes and Infection Comorbidity
Chemerin Exacerbates Pulmonary Inflammation in Type 2 Diabetes and Infection Comorbidity
The adipokine chemerin is increased in the serum of individuals with obesity and type 2 diabetes. Patients with type 2 dia...
Angiotensin-(1–7) Mitigates Progression from Acute Kidney Injury to Chronic Kidney Disease Via Renin-Angiotensin System Modulation in a Murine Model
Angiotensin-(1–7) Mitigates Progression from Acute Kidney Injury to Chronic Kidney Disease Via Renin-Angiotensin System Modulation in a Murine Model
Background. Acute kidney injury (AKI) often progresses to chronic kidney disease (CKD), presenting a significant ...
Identification and Experimental Validation of OS-Related Gene Sets Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data with Machine Learning in Patients with Sepsis
Identification and Experimental Validation of OS-Related Gene Sets Based on Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data with Machine Learning in Patients with Sepsis
Sepsis is a severe organ dysfunction syndrome caused by a dysregulated host response to infection, closely associated with...
Evaluation of Cardiac IL-11 and IL-11Rα Expression During Infection
Evaluation of Cardiac IL-11 and IL-11Rα Expression During Infection
Chagas disease (CD), caused by Trypanosoma cruzi, leads to cardiomyopathy in approximately 20–30% of infected indivi...
Expression and regulation network of BLNK in CP/CPPS in animal, cell model and clinical samples
Expression and regulation network of BLNK in CP/CPPS in animal, cell model and clinical samples
B-cell linker (BLNK) is associated with the inflammatory process of certain diseases. However, no studies have explored th...
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis
RBPJ Knockdown Promotes M2 Macrophage Polarization Through Mitochondrial ROS-mediated Notch1-Jagged1-Hes1 Signaling Pathway in Uveitis
Uveitis is an autoimmune eye disease that can be involved in the entire body and is one of the leading causes of blindness...
BRG1 Deficiency Promotes Cardiomyocyte Inflammation and Apoptosis by Activating the cGAS-STING Signaling in Diabetic Cardiomyopathy
BRG1 Deficiency Promotes Cardiomyocyte Inflammation and Apoptosis by Activating the cGAS-STING Signaling in Diabetic Cardiomyopathy
Brahma-related gene 1 (BRG1) has been implicated in the repair of DNA double-strand breaks (DSBs). Downregulation of BRG1 ...
Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis
Celastrol Regulates the Hsp90-NLRP3 Interaction to Alleviate Rheumatoid Arthritis
Previous studies have verified that celastrol (Cel) protects against rheumatoid arthritis (RA) by inhibiting the NLRP3 inf...
Dexmedetomidine Alleviates Acute Stress-Induced Acute Kidney Injury by Attenuating Inflammation and Oxidative Stress via Inhibiting the P2X7R/NF-κB/NLRP3 Pathway in Rats
Dexmedetomidine Alleviates Acute Stress-Induced Acute Kidney Injury by Attenuating Inflammation and Oxidative Stress via Inhibiting the P2X7R/NF-κB/NLRP3 Pathway in Rats
This study aimed to investigate the potential protective effects of Dexmedetomidine (DEX) against acute kidney injury (AKI...
Angiotensin II Type 2 Receptor Inhibits M1 Polarization and Apoptosis of Alveolar Macrophage and Protects Against Mechanical Ventilation-Induced Lung Injury
Angiotensin II Type 2 Receptor Inhibits M1 Polarization and Apoptosis of Alveolar Macrophage and Protects Against Mechanical Ventilation-Induced Lung Injury
Angiotensin II (Ang II) is associated with macrophage polarization and apoptosis, but the role of the angiotensin type 2 r...
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