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Role of adiponectin and its receptors AdipoR1/2 in inflammatory bowel disease
Role of adiponectin and its receptors AdipoR1/2 in inflammatory bowel disease
Intake of nutrients and water from diet to maintain life, a typical physiological function of gut, is highly dependent on ...
Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask
Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask
Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental proce...
High-fat diet impairs microbial metabolite production and aggravates influenza A infection
High-fat diet impairs microbial metabolite production and aggravates influenza A infection
Alterations in the gut microbiom can significantly impact various regions in the human body, including the pulmonary tract...
Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting AChR clustering
Synergic action of MicroRNAs and Wnts delivered by motor neuron EVs in promoting AChR clustering
The neuromuscular junction (NMJ) establishment occurs through complex communication events between motor neurons and muscl...
The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection
The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection
Influenza A viruses (IAVs) initially infect a few host cells before spreading to neighboring cells. However, the molecular...
Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes
Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes
Beyond their conventional roles in hemostasis and wound healing, platelets have been shown to facilitate hematogenous meta...
STING exerts antiviral innate immune response by activating pentose phosphate pathway
STING exerts antiviral innate immune response by activating pentose phosphate pathway
The innate immune system serves as the host’s first line of defense against invading pathogens. Stimulator of interf...
Adipose tissue protects against skin photodamage through CD151- and AdipoQ- EVs
Adipose tissue protects against skin photodamage through CD151- and AdipoQ- EVs
To clarify the protective effects of subcutaneous adipose tissue (SAT) against photodamage, we utilized nude mouse skin wi...
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes
Anthracycline antitumor drug doxorubicin (DOX) induces severe cardiotoxicity. Deubiquitinating enzymes (DUBs) are crucial ...
Applications of lung cancer organoids in precision medicine: from bench to bedside
Applications of lung cancer organoids in precision medicine: from bench to bedside
As the leading cause of cancer-related mortality, lung cancer continues to pose a menacing threat to human health worldwid...
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Correction: Extracellular vesicles of the probiotic bacteria E. coli O83 activate innate immunity and prevent allergy in mice
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines: their significance for maintaining health and contributing to diseases
Polyamines are essential for the growth and proliferation of mammalian cells and are intimately involved in biological mec...
New insights into the stemness of adoptively transferred T cells by γc family cytokines
New insights into the stemness of adoptively transferred T cells by γc family cytokines
T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthr...
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
A missense mutant of ocrl1 promotes apoptosis of tubular epithelial cells and disrupts endocytosis and the cell cycle of podocytes in Dent-2 Disease
This study aimed to identify an orcl1 mutation in a patient with Dent-2 Disease and investigate the underlying mechanisms....
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regul...
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach
Despite improved patient outcome using tyrosine kinase inhibitors (TKIs), chronic myeloid leukaemia (CML) patients require...
Natural killer cells in the central nervous system
Natural killer cells in the central nervous system
Natural killer (NK) cells are essential components of the innate lymphoid cell family that work as both cytotoxic effector...
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cy...
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various ...
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery
Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a...
Targeting ferroptosis in melanoma: cancer therapeutics
Targeting ferroptosis in melanoma: cancer therapeutics
Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for ...
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Preeclampsia impedes foetal kidney development by delivering placenta-derived exosomes to glomerular endothelial cells
Foetal renal dysplasia is still the main cause of adult renal disease. Placenta-derived exosomes are an important communic...
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 rece...
New insights into the regulation of METTL3 and its role in tumors
New insights into the regulation of METTL3 and its role in tumors
As one of the most abundant epigenetic modifications in RNA, N6-methyladenosine (m6A) affects RNA transcription, splicing,...
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is com...
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation – A meta-analysis
Although interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been i...
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
IL-1β mediates the induction of immune checkpoint regulators IDO1 and PD-L1 in lung adenocarcinoma cells
Inflammation plays a significant role in various cancers, including lung cancer, where the inflammatory cytokine IL-1β...
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
The impact of erythroblast enucleation efficiency on the severity of anemia in patients with myelodysplastic syndrome
Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoi...
PKCδ regulates the vascular biology in diabetic atherosclerosis
PKCδ regulates the vascular biology in diabetic atherosclerosis
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social p...
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival
Glioblastoma is the most common and aggressive primary brain tumor with extremely poor prognosis, highlighting an urgent n...
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