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Atto 465 Derivative Is a Nuclear Stain with Unique Excitation and Emission Spectra Useful for Multiplex Immunofluorescence Histochemistry
Atto 465 Derivative Is a Nuclear Stain with Unique Excitation and Emission Spectra Useful for Multiplex Immunofluorescence Histochemistry
Multiplex immunofluorescence (mIF) is an effective technique for the maximal visualization of multiple target proteins in ...
Prognostic Value of the Immunohistochemical Expression of RAD51 and BRCA2 in Gastric Adenocarcinoma
Prognostic Value of the Immunohistochemical Expression of RAD51 and BRCA2 in Gastric Adenocarcinoma
Current scientific literature lacks data on the prognostic value of the expression of RAD51 and BRCA2 in gastric adenocarc...
IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy
IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy
Isocitrate dehydrogenase 1 and 2 (IDH1/2) are enzymes recurrently mutated in various types of cancer, including glioma, ch...
Morphometric and Immunohistochemical Characteristics of the Adult Human Soft Palate Muscles
Morphometric and Immunohistochemical Characteristics of the Adult Human Soft Palate Muscles
The soft palate is the only structure that reversibly separates the respiratory and gastrointestinal systems. Most species...
Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth
Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth
Although it is thought that there is a close relationship between Notch signal and preterm birth, the functioning of this ...
Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue
Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue
Primary obstructive megaureter (POM) morphogenesis is not fully known. The aim of the study was to evaluate the appearance...
Mitochondrial Localization of CB1 in Progesterone-producing Cells of Ovarian Interstitial Glands of Adult Mice
Mitochondrial Localization of CB1 in Progesterone-producing Cells of Ovarian Interstitial Glands of Adult Mice
Localization of cannabinoid receptor type 1 (CB1) immunoreactivity on mitochondrial membranes, at least their outer membra...
Effects of Alendronate and Dexamethasone on Osteoclast Gene Expression and Bone Resorption in Mouse Marrow Cultures
Effects of Alendronate and Dexamethasone on Osteoclast Gene Expression and Bone Resorption in Mouse Marrow Cultures
Osteoclasts are cells whose main function is the resorption of bone matrix. However, several factors, including medication...
Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas
Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas
Recent evidence supports the fimbriae of the fallopian tube as one origin site for high-grade serous ovarian cancer (HGSOC...
Defining a (Cancer Stem Cell) Niche
Defining a (Cancer Stem Cell) Niche
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity
Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity
Immune checkpoint inhibitors have become the mainstay of treatment for hepatocellular carcinoma (HCC). However, they are i...
Proteomic Distributions in CD34+ Microvascular Niche Patterns of Glioblastoma
Proteomic Distributions in CD34+ Microvascular Niche Patterns of Glioblastoma
The poor clinical prognosis and microvascular patterns of glioblastoma (GBM) are of serious concern to many clinicians and...
Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence
Comparison of Fixation Methods for the Detection of Claudin 1 and E-Cadherin in Breast Cancer Cell Lines by Immunofluorescence
The tight junction membrane protein claudin 1 and the adherens junction protein E-cadherin play critical roles in cell–cel...
Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow
Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow
Energy production by means of ATP synthesis in cancer cells has been investigated frequently as a potential therapeutic ta...
Latency-associated Peptide Degradation Fragments Produced in Stellate Cells and Phagocytosed by Macrophages in Bile Duct-ligated Mouse Liver
Latency-associated Peptide Degradation Fragments Produced in Stellate Cells and Phagocytosed by Macrophages in Bile Duct-ligated Mouse Liver
Transforming growth factor-β (TGF-β) activation is involved in various pathogeneses, such as fibrosis and malignancy. We p...
Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer
Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer
The role of Wnt family proteins, E-cadherin, and β-catenin in non-small cell lung cancer (NSCLC) is unclear. In this study...
Type I Interferon Signaling Increases Versican Expression and Synthesis in Lung Stromal Cells During Influenza Infection
Type I Interferon Signaling Increases Versican Expression and Synthesis in Lung Stromal Cells During Influenza Infection
Versican, a chondroitin sulfate proteoglycan, is an essential component of the extracellular matrix (ECM) in inflammatory ...
Regulation of Endothelial Nitric Oxide Synthase in the Reticular Lamina of the Organ of Corti by a Nitric Oxide Donor
Regulation of Endothelial Nitric Oxide Synthase in the Reticular Lamina of the Organ of Corti by a Nitric Oxide Donor
In the vertebrate cochlea, the reticular lamina seals the organ of Corti against the endolymph filled scala media. After n...
Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma
Carbonic Anhydrases II and IX in Non-ampullary Duodenal Adenomas and Adenocarcinoma
Non-ampullary duodenal adenocarcinoma (DAC) is a rare malignancy. Little information is available concerning the histopath...
Considerations for Whole-Slide Analysis of Murine Xenografts Experiments
Considerations for Whole-Slide Analysis of Murine Xenografts Experiments
Histochemistry of tumor sections is a widely employed technique utilized to examine cell death in preclinical xenograft an...
The Conspicuousness of High Endothelial Venules in Angioimmunoblastic T-cell Lymphoma Is Due to Increased Cross-sectional Area, Not Increased Distribution Density
The Conspicuousness of High Endothelial Venules in Angioimmunoblastic T-cell Lymphoma Is Due to Increased Cross-sectional Area, Not Increased Distribution Density
Angioimmunoblastic T-cell lymphoma (AITL) is a T-cell lymphoma of follicular helper T-cell origin. Histologically, neoplas...
Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness
Emerging Roles of DLK1 in the Stem Cell Niche and Cancer Stemness
DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane protein Delta-like homologue 1 (DLK...
Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon
Picrosirius Red Staining: Revisiting Its Application to the Qualitative and Quantitative Assessment of Collagen Type I and Type III in Tendon
Collagen has a major role in the structural organization of tendons. Picrosirius red (PSR) staining viewed under polarized...
Rejuvenated Vintage Tissue Sections Highlight Individual Antigen Fate During Processing and Long-term Storage
Rejuvenated Vintage Tissue Sections Highlight Individual Antigen Fate During Processing and Long-term Storage
Antigen-bearing proteins become progressively unavailable to immunodetection after prolonged storage of routine sections, ...
Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats
Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats
Non-alcoholic steatohepatitis (NASH) is a worldwide health problem. Alternate-day fasting (ADF), although thought to be ag...
Improvement in Double Staining With Fluoro-Jade C and Fluorescent Immunostaining: FJC Staining Is Not Specific to Degenerating Mature Neurons
Improvement in Double Staining With Fluoro-Jade C and Fluorescent Immunostaining: FJC Staining Is Not Specific to Degenerating Mature Neurons
Fluoro-Jade C (FJC) staining has been used to detect degenerating neurons in tissue sections. It is a simple and easy stai...
Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson’s Trichrome
Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson’s Trichrome
With the advent of checkpoint inhibitors, there is increasing need to study the dynamics of CD8+ T-cells in the tumor micr...
SPM Receptor Expression and Localization in Irradiated Salivary Glands
SPM Receptor Expression and Localization in Irradiated Salivary Glands
Radiation therapy–mediated salivary gland destruction is characterized by increased inflammatory cell infiltration and fib...
Apical Membrane Expression of Distinct Sulfated Glycans Is a Characteristic Feature of Ductules and Their Reactive and Neoplastic Counterparts
Apical Membrane Expression of Distinct Sulfated Glycans Is a Characteristic Feature of Ductules and Their Reactive and Neoplastic Counterparts
Intrahepatic bile ducts transport bile between bile canaliculi and the extrahepatic bile duct. The luminal surface of this...
Proteases Regulate Cancer Stem Cell Properties and Remodel Their Microenvironment
Proteases Regulate Cancer Stem Cell Properties and Remodel Their Microenvironment
Proteolytic activity is perturbed in tumors and their microenvironment, and proteases also affect cancer stem cells (CSCs)...
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