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Current and Future Clinical Applications of ctDNA in Immuno-Oncology
Current and Future Clinical Applications of ctDNA in Immuno-Oncology
AbstractTesting peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive opportunity to diagnose, ch...
EZH2 Inhibitors: The Unpacking Revolution
EZH2 Inhibitors: The Unpacking Revolution
The methylation of lysine 27 on histone H3 (H3K27me3) is a chromatin mark associated with nucleosome condensation and gene...
Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research
Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research
AbstractIt is only recently that drugs targeting K-RAS and Tp53 missense mutations have been developed, and along with the...
Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses
Mammary Tumor-Derived Transplants as Breast Cancer Models to Evaluate Tumor-Immune Interactions and Therapeutic Responses
In breast cancer, the type and distribution of infiltrating immune cells are associated with clinical outcome. Moreover, c...
Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression
Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression
Analysis of the Estrogen Receptor-Associated LncRNA Landscape Identifies a Role for ERLC1 in Breast Can...
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma
Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma
AbstractGlioblastoma is the most prevalent primary malignant brain tumor in adults and is characterized by poor prognosis ...
BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma
BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma
The tumor stroma and its cellular components are known to play an important role in tumor response to treatment. Here, we ...
Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma
Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma
AbstractMultiple myeloma is an incurable malignancy with marked clinical and genetic heterogeneity. The cytogenetic abnorm...
Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21
Inhibition of ERK5 Elicits Cellular Senescence in Melanoma via the Cyclin-Dependent Kinase Inhibitor p21
AbstractMelanoma is the deadliest skin cancer with a very poor prognosis in advanced stages. Although targeted and immune ...
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype
Polypharmacologic Reprogramming of Tumor-Associated Macrophages toward an Inflammatory Phenotype
Tumor-associated macrophages (TAM) are an important component of the tumor microenvironment (TME) that can promote tumor p...
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy Alva...
Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression
Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression
Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppress...
Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation
Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell Sensitivity to Radiation
Loss of FBXW7 Correlates with Increased IDH1 Expression in Glioma and Enhances IDH1-Mutant Cancer Cell ...
Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Ellen M. Westerhout, Mohamed Hamdi, P...
A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture
A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture
AbstractOptimal treatment of cancer requires diagnostic methods to facilitate therapy choice and prevent ineffective treat...
Myeloid Cell-Derived Oxidized Lipids and Regulation of the Tumor Microenvironment
Myeloid Cell-Derived Oxidized Lipids and Regulation of the Tumor Microenvironment
2Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania.3Department of Ch...
Hypoxia-Inducible Factors in Cancer
Hypoxia-Inducible Factors in Cancer
AbstractLow oxygen concentrations (hypoxia) are detrimental to most species on Earth; thus, cells have evolved with adapta...
Chemotherapy Triggers T Cells to Remodel the Extracellular Matrix and Promote Metastasis
Chemotherapy Triggers T Cells to Remodel the Extracellular Matrix and Promote Metastasis
Chemotherapy can impede cancer progression and is a well-demonstrated component of curative care for some patients with no...
Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors
Clonal Hematopoiesis Mutations in Patients with Lung Cancer Are Associated with Lung Cancer Risk Factors
AbstractClonal hematopoiesis (CH) is a phenomenon caused by expansion of white blood cells descended from a single hematop...
Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer
Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer
1Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.3Depar...
KMT9 Controls Stemness and Growth of Colorectal Cancer
KMT9 Controls Stemness and Growth of Colorectal Cancer
KMT9 Controls Stemness and Growth of Colorectal Cancer Christopher Berlin, Félicie Cottard, Domi...
Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer
Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer
Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer ...
Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma
Human Endogenous Retrovirus Type K Promotes Proliferation and Confers Sensitivity to Antiretroviral Drugs in Merlin-Negative Schwannoma and Meningioma
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can o...
T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
AbstractMetastasis is the main cause of cancer-related mortality. Despite intense efforts to understand the mechanisms und...
BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment
AbstractEmerging evidence indicates B-cell activating factor (BAFF, Tnfsf13b) to be an important cytokine for antitumor im...
Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma
AbstractPARP inhibitors (PARPi) have activity in homologous recombination (HR) repair-deficient, high-grade serous ovarian...
Inhibition of FGFR Reactivates IFN{gamma} Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies
Inhibition of FGFR Reactivates IFN{gamma} Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies
AbstractCombination therapies consisting of immune checkpoint inhibitors plus anti-VEGF therapy show enhanced antitumor ac...
Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis
Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis
Convergence and Technologies Weisi Xie, Nicholas P. Reder, Can Koyuncu, Patrick Leo, Sar...
Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability
Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability
Basal-like breast cancer is the most aggressive breast cancer subtype with the worst prognosis. Despite its high recurrenc...
The Protein Kinase Activity of NME7 Activates Wnt/{beta}-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
The Protein Kinase Activity of NME7 Activates Wnt/{beta}-Catenin Signaling to Promote One-Carbon Metabolism in Hepatocellular Carcinoma
The Protein Kinase Activity of NME7 Activates Wnt/β-Catenin Signaling to Promote One-Carbon Metabolism ...
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