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Microplastics but macro-concerns on the brain
Microplastics but macro-concerns on the brain
Microplastics and nanoplastics (MNPs) are increasingly recognized as pervasive environmental exposures. Li et al. analysed...
Remembering inflammation increases cancer risk
Remembering inflammation increases cancer risk
Colitis predisposes to colorectal cancer, but how inflammation promotes tumour initiation has remained unclear. Nagaraja e...
Stem cells as an essential mediator of the exercise–tumorigenesis link
Stem cells as an essential mediator of the exercise–tumorigenesis link
Aerobic exercise has a profound influence on host physiology and cancer risk, yet the mechanisms of how these are linked r...
Regulation of immune checkpoint molecules in cancer immune evasion and therapy
Regulation of immune checkpoint molecules in cancer immune evasion and therapy
Immune checkpoint molecules are essential regulators of immune homeostasis, maintaining the balance between activation and...
Tracing disease origin with plasma cell-free chromatin
In this Tools of the Trade article, Xiaoxuan Meng describes the development of cf-EpiTracing, a highly sensitive and autom...
Mesenchymal stromal/stem cells in tumour initiation, progression and therapy
Mesenchymal stromal/stem cells in tumour initiation, progression and therapy
The expanding study of mesenchymal stromal/stem cells (MSC) in cancer has amounted to a growing understanding of their und...
Beyond sex determination: the Y chromosome in male cancers
Beyond sex determination: the Y chromosome in male cancers
Loss of the Y chromosome (LOY) is the most prevalent somatic genomic alteration in males and can be detected in both blood...
Beat it!
Beat it!
The heart is strikingly resistant to tumour formation despite its rich vascularization. In a recent study, Ciucci, Lorizio...
Tumour hypoxia in driving genomic instability and tumour evolution
Tumour hypoxia in driving genomic instability and tumour evolution
Intratumour hypoxia is a feature of all heterogenous solid tumours. Increased levels or subregions of tumour hypoxia are a...
Cross-priming in cancer immunology and immunotherapy
Cross-priming in cancer immunology and immunotherapy
Cytotoxic T cell immune responses against cancer crucially depend on the ability of a subtype of professional antigen-pres...
Allies in the epidermis
Allies in the epidermis
Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that comm...
Small speckles, big impact
Small speckles, big impact
In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression ...
Maximizing the dual benefit of pet dogs in cancer trials
Maximizing the dual benefit of pet dogs in cancer trials
Pet dogs with cancer have catalysed the translation of preclinical discoveries to first-in-human trials, highlighting the ...
Dendritic cell maturation in cancer
Dendritic cell maturation in cancer
Dendritic cells (DCs) are specialized antigen-presenting cells that are present at low abundance in the circulation and ti...
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer
Mathematical modelling has proven to be a valuable tool in predicting the delivery and efficacy of molecular, antibody-bas...
Defining a ‘cells to society’ research framework for appendiceal tumours
Defining a ‘cells to society’ research framework for appendiceal tumours
Tumours of the appendix — a vestigial digestive organ attached to the colon — are rare. Although we estimate t...
Pressing defence
Pressing defence
In this study, Bansaccal et al. analyse why, at some skin locations, oncogene-expressing cells rarely progress to cancer a...
How chemokines organize the tumour microenvironment
How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must...
Targeting cancer cell dormancy
The field of tumour dormancy, originally defined as a clinical phenomenon of late recurrence after a long, apparently dise...
Fcγ receptors and immunomodulatory antibodies in cancer
Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as neg...
Removing barriers to address sex differences in anticancer drug toxicity
Removing barriers to address sex differences in anticancer drug toxicity
Despite the compelling evidence for greater toxicity in female patients, sex-specific anticancer treatment strategies are ...
Lighting up cancer initiation with mutant p53 reporters
In this Tools of the Trade article, Xiwen Tang describes the development of in vivo reporters detecting mutant p53 at the ...
The dynamic role of platelets in cancer progression and their therapeutic implications
The dynamic role of platelets in cancer progression and their therapeutic implications
Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy...
UXS1: a sweet spot for cell death
UXS1: a sweet spot for cell death
Enzymes that produce metabolites specifically required by cancer cells have become attractive targets for therapy. Recentl...
Eph receptors and ephrins in cancer progression
Eph receptors and ephrins in cancer progression
Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together make up the ‘Eph...
Understanding and addressing race disparities in childhood cancer outcomes
Vulnerable populations remain disproportionately at risk for inferior childhood cancer outcomes. Here, I outline the scope...
Translating tumour immunity control
In this Journal Club, Hajj discusses a study demonstrating that oncogene activation modulates immune control through both ...
The microbiome as a determinant of racial and ethnic cancer disparities
The microbiome as a determinant of racial and ethnic cancer disparities
 People from minority racial and ethnic groups continue to experience disproportionate cancer incidences and canc...
How protons pave the way to aggressive cancers
How protons pave the way to aggressive cancers
Cancers undergo sequential changes to proton (H+) concentration and sensing that are consequences of the disease and facil...
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic pathway analysis using stable isotopes in patients with cancer
Metabolic reprogramming is central to malignant transformation and cancer cell growth. How tumours use nutrients and the r...
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