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Live-cell imaging of mammary organoids using light sheet microscopy
Live-cell imaging of mammary organoids using light sheet microscopy
The mammary gland is a dynamic organ whose parenchyma undergoes major development during puberty and extensive remodeling ...
Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer?
Does microtubule motor-mediated centrosomal dyshomeostasis confer chemoresistance in breast cancer?
Chemoresistance is a major challenge in effective chemotherapy for breast cancers. Unfortunately, the precise molecular me...
MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice
MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice
The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response...
Natural and induced epithelial-mesenchymal transition results in epigenetic silencing of HER2 overexpression
Natural and induced epithelial-mesenchymal transition results in epigenetic silencing of HER2 overexpression
Epithelial-mesenchymal transition (EMT) is a well-known phenomenon that has been implicated in diverse biological processe...
Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation
Little women: the relevance and reliance on mouse models for mammary gland research and next steps for translation
The neglect of research into women’s health and female biology has had major impacts for the fields of mammary biolo...
BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer
BRCA1: An Unrecognized Modulator of Lineage Plasticity in Basal-like Breast Cancer
Among breast cancer subtypes, basal-like breast cancer (BLBC) is a highly aggressive form characterized by a lack of estro...
Breast Cancer Progression by the FGF/FGFR Axis: A Metabolic Perspective
Breast Cancer Progression by the FGF/FGFR Axis: A Metabolic Perspective
Fibroblast growth factor receptors (FGFRs) are critical mediators of cellular signaling involved in development, tissue re...
Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research
Imaging and Diagnostic Tools for Cetacean Mammary Gland Assessment: Challenges and Future Directions for Marine Mammal Pathology, Medicine and Research
Reproduction studies are important for the conservation of cetaceans (whales, dolphins, and porpoises) because they provid...
Increased Toll-Like Receptor-4 Signalling in Breast Tissue of High Fibroglandular Density
Increased Toll-Like Receptor-4 Signalling in Breast Tissue of High Fibroglandular Density
High mammographic breast density relates to the abundance of fibroglandular tissue in comparison to fatty tissue in the br...
Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality
Characterizing Human Milk RNA Degradation Over Time to Optimize Storage of Human Milk for RNA Quality
Human milk is rich in bioactive components beyond nutrition, including RNAs—especially miRNAs. It is the most RNA-ri...
Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer
Synergistic Anticancer Effects of Apatinib and PD-L1 Inhibition in Breast Cancer
Studies in breast cancer have demonstrated that apatinib exhibits both antiangiogenic and antitumor effects, while PD-L1 i...
Patient-Derived Procoagulant Breast Fibroblasts Expressing Tissue Factor Promote Breast Cancer Cell Migration
Patient-Derived Procoagulant Breast Fibroblasts Expressing Tissue Factor Promote Breast Cancer Cell Migration
Cancer-associated fibroblasts (CAFs) play a key role in breast cancer progression and exhibit a procoagulant phenotype wit...
Defective Mammary Epithelial Outgrowth in Transgenic EKAREV–NLS Mice: Correction via Estrogen Supplementation and Genetic Background Modification
Defective Mammary Epithelial Outgrowth in Transgenic EKAREV–NLS Mice: Correction via Estrogen Supplementation and Genetic Background Modification
Fluorescent biosensors offer a powerful tool for tracking and quantifying protein activity in living systems with high tem...
Recurrent Nipple Duct Obstruction in Two Breastfeeding Patients: A Case Report and Discussion of the Underlying Pathophysiology
Recurrent Nipple Duct Obstruction in Two Breastfeeding Patients: A Case Report and Discussion of the Underlying Pathophysiology
Nipple pain is a common reason for premature breastfeeding cessation. There exists anecdotal evidence that one cause of la...
Mammalian Species-Specific Resistance to Mammary Cancer
Mammalian Species-Specific Resistance to Mammary Cancer
Tumorigenesis in mammals is driven by inherited genetic variants, environmental factors and random errors during normal DN...
Buenos Aires Breast Cancer Symposium (BA-BCS 2024) A Second Successful “Trial” for Bringing Together both World Hemispheres To Debate the Future of Translational Breast Cancer Research
Buenos Aires Breast Cancer Symposium (BA-BCS 2024) A Second Successful “Trial” for Bringing Together both World Hemispheres To Debate the Future of Translational Breast Cancer Research
The second edition of the Buenos Aires Breast Cancer Symposium (BA-BCS), the first held in person, took place from Septemb...
Association of , , and Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study
Association of , , and Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study
Breast cancer is a complex disease characterized by the uncontrolled growth of breast cells. Genetic variants in ESR1, HER...
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development
Disease-Associated Mutations of the STAT5B SH2 Domain Regulate Cytokine-Driven Enhancer Function and Mammary Development
Mammary gland development during pregnancy is controlled by lactogenic hormones via the JAK2-STAT5 pathway. Gene deletion ...
Developmental Regulation of circRNAs in Normal and Diseased Mammary Gland: A Focus on circRNA-miRNA Networks
Developmental Regulation of circRNAs in Normal and Diseased Mammary Gland: A Focus on circRNA-miRNA Networks
Circular RNAs (circRNAs) have emerged as critical regulators in various biological processes including diseases. In the ma...
biogrowleR: Enhancing Longitudinal Data Analysis
biogrowleR: Enhancing Longitudinal Data Analysis
Time course measurements are used for many applications in biomedical research, ranging from growth curves to drug efficac...
Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland
Intraductal Injection of Adenoviruses to Perform Lineage Tracing in the Mammary Gland
Lineage tracing is a fundamental tool in developmental biology and cancer research, providing critical insights into cell ...
Reactivation of Multipotency in the Mammary Gland – a Ripple in the Pond and a Turn of the Tide
Reactivation of Multipotency in the Mammary Gland – a Ripple in the Pond and a Turn of the Tide
Multipotency refers to the ability of a cell to differentiate into multiple, yet limited as opposed to pluripotency, numbe...
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female Hormones
During female adolescence and pregnancy, rising levels of hormones result in a cyclic source of signals that control the d...
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
Fast Ultrasound Scanning is a Rapid, Sensitive, Precise and Cost-Effective Method to Monitor Tumor Grafts in Mice
In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding cancer biology and evaluating t...
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Protocols for Co-Culture Phenotypic Assays with Breast Cancer Cells and THP-1-Derived Macrophages
Tumor mass comprises not only cancer cells but also heterogeneous populations of immune and stromal cells, along with the ...
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
Spatial Engineering of Mammary Epithelial Cell Cultures with 3D Bioprinting Reveals Growth Control by Branch Point Proximity
The three-dimensional (3D) structure of the ductal epithelium and the surrounding extracellular matrix (ECM) are integral ...
Using Organoids to Tap Mammary Gland Diversity for Novel Insight
Using Organoids to Tap Mammary Gland Diversity for Novel Insight
This article offers a comprehensive perspective on the transformative role of organoid technology on mammary gland biology...
Exploring the One Health Paradigm in Male Breast Cancer
Exploring the One Health Paradigm in Male Breast Cancer
How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowle...
A novel preclinical model of the normal human breast
A novel preclinical model of the normal human breast
Improved screening and treatment have decreased breast cancer mortality, although incidence continues to rise. Women at in...
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth
Signal transducers and activators of transcription (STAT) proteins regulate mammary development. Here we investigate the e...
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