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Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death
Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death
Flavonoids are plant-derived polyphenols widely found in fruits, vegetables, and herbs, and have attracted growing interes...
Engineered mesenchymal stem cells expressing CXCR4 and LIGHT enhance Anti-Tumor activity in a subcutaneous gastric cancer xenograft model
Engineered mesenchymal stem cells expressing CXCR4 and LIGHT enhance Anti-Tumor activity in a subcutaneous gastric cancer xenograft model
Gastric cancer remains a leading cause of cancer-related mortality, with limited treatment options and a poor prognosis. M...
Loss of junctional plakoglobin (JUP) activates PI3K/AKT signaling in head and neck squamous cell carcinoma
Loss of junctional plakoglobin (JUP) activates PI3K/AKT signaling in head and neck squamous cell carcinoma
Head and neck squamous cell carcinomas (HNSCC) are characterized by poor prognosis, primarily due to early metastatic spre...
Maleimide-substituted 1,4-naphthoquinone flaviolin mimetic (FM) induces S-phase arrest and mitochondria-mediated apoptosis in multiple myeloma cells
Maleimide-substituted 1,4-naphthoquinone flaviolin mimetic (FM) induces S-phase arrest and mitochondria-mediated apoptosis in multiple myeloma cells
Effective treatment for multiple myeloma remains a significant clinical challenge due to multidrug resistance and the side...
Dysregulated immune microenvironment in metastatic colorectal cancer
Dysregulated immune microenvironment in metastatic colorectal cancer
Emerging evidence highlights that metastatic colorectal cancer (mCRC) can occur early in tumor progression, with its uniqu...
FN1 as a key gene in modulating the integrin cell surface pathway in breast cancer
FN1 as a key gene in modulating the integrin cell surface pathway in breast cancer
Breast carcinoma represents the most prevalent form of invasive neoplasia among the female population globally, and is dis...
Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model
Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model
Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often ...
Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells
Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells
Ellagic acid (EA) is a natural polyphenol noted for its antiproliferative and pro-apoptotic effects. This study investigat...
Piperine-induced AMPK activation and cell cycle arrest: insights from molecular simulations and experimental validation in breast cancer
Piperine-induced AMPK activation and cell cycle arrest: insights from molecular simulations and experimental validation in breast cancer
Breast cancer remains a leading cause of mortality among women, underscoring the need for novel, low-toxicity therapeutic ...
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer
ULK1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited targeted therapies and poor prognosis. Unc-51-l...
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis
Deltaretroviruses, including Human T-cell Leukemia Virus type 1 (HTLV-1) and Bovine Leukemia Virus (BLV), are oncogenic pa...
A different perspective on the cancer stem cell theory
A different perspective on the cancer stem cell theory
Increased recurrence risk, aggressiveness, metastasis, and poor prognosis of cancer disease are challenges of conventional...
 ethyl acetate extract suppresses HepG2 hepatocellular carcinoma cell proliferation via PCNA downregulation and mitochondria-mediated apoptosis
 ethyl acetate extract suppresses HepG2 hepatocellular carcinoma cell proliferation via PCNA downregulation and mitochondria-mediated apoptosis
Merremia tridentata of the Convolvulaceae family exhibits multiple therapeutic properties and is commonly utilized in ethn...
Research progress and clinical translation challenges in the use of oncolytic bacteria for cancer therapy
Research progress and clinical translation challenges in the use of oncolytic bacteria for cancer therapy
Oncolytic bacteria represent a distinct group of microorganisms capable of selectively infecting and colonizing tumor tiss...
A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury
A natural nephroprotective adjuvant for cancer chemotherapy: Rosmarinic acid disrupts IL-17 A-Ferroptosis coupling in Ifosfamide-induced renal injury
Rosmarinic acid (RA) is a natural polyphenol with established pleiotropic protective effects. Ifosfamide (IFA) is a potent...
Patient-derived spheroid culture: A promising in vitro model for drug screening in retinoblastoma
Patient-derived spheroid culture: A promising in vitro model for drug screening in retinoblastoma
In retinoblastoma (RB), the search for newer therapeutics is a thrust area for better disease management, and there is a l...
Disrupting the USP1–UAF1 deubiquitinase complex: a master regulator of replication stress and frontier target in cancer therapy
Disrupting the USP1–UAF1 deubiquitinase complex: a master regulator of replication stress and frontier target in cancer therapy
Replication stress is a therapeutic vulnerability in cancer, and the deubiquitinase USP1, in complex with its WD40 cofacto...
Glioma–Immune crosstalk in the tumor microenvironment: mechanistic insights and therapeutic translation
Glioma–Immune crosstalk in the tumor microenvironment: mechanistic insights and therapeutic translation
Tumor progression is governed not only by genetic alterations but also by the dynamic interplay within the tumor microenvi...
Investigation of anticancer potential of a novel bioactive molecule from Trichosporon asahii VITSTB1 in breast cancer cell lines: an in vitro study
Investigation of anticancer potential of a novel bioactive molecule from Trichosporon asahii VITSTB1 in breast cancer cell lines: an in vitro study
The current study investigates the anticancer activity of protein derived from yeast against breast cancer. Yeast-derived ...
The physician payments Sunshine Act and medical oncology: a seven-year financial analysis
The physician payments Sunshine Act and medical oncology: a seven-year financial analysis
The integration of pharmaceutical and medical device companies with clinical practice is under scrutiny due to financial i...
Co-culture system of breast cancer and normal cells to investigate inflammation: using doxorubicin encapsulated in adipose-derived exosomes
Co-culture system of breast cancer and normal cells to investigate inflammation: using doxorubicin encapsulated in adipose-derived exosomes
Doxorubicin (DOX) chemotherapy for breast cancer is an effective treatment option, but it also has disadvantages. Exosomes...
Cedrus atlantica extract inhibits melanoma progression by suppressing epithelial-mesenchymal transition and inducing mitochondria-mediated apoptosis
Cedrus atlantica extract inhibits melanoma progression by suppressing epithelial-mesenchymal transition and inducing mitochondria-mediated apoptosis
Melanoma has a low incidence, accounting for less than 5% of skin cancers; however, it is the most lethal cancer, primaril...
Metabolic dysregulation in myelodysplastic neoplasm: impact on pathogenesis and potential therapeutic targets
Metabolic dysregulation in myelodysplastic neoplasm: impact on pathogenesis and potential therapeutic targets
Despite significant advancements in the research of the pathogenesis mechanisms of Myelodysplastic Neoplasm (MDS) in recen...
Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation
Betulinic acid and oleanolic acid modulate CD81 expression and induce apoptosis in triple-negative breast cancer cells through ROS generation
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by a lack of hormones recepto...
Progression and perspectives in disease modeling for Juvenile myelomonocytic leukemia
Progression and perspectives in disease modeling for Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative neoplasm occurring in infants and young children. JMM...
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment
The integration of nanotechnology into cancer treatment has revolutionized chemotherapy, boosted its effectiveness while r...
Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Salmonella-based therapeutic strategies: improving tumor microenvironment and bringing new hope for cancer immunotherapy
Immunotherapy has revolutionized cancer treatment, yet its effectiveness is limited by immunosuppressive tumor microenviro...
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy
Paclitaxel (PTX) is widely used for treating several cancers, including breast, ovarian, lung, esophageal, gastric, pancre...
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Sorcin: mechanisms of action in cancer hallmarks, drug resistance and opportunities in therapeutics
Soluble resistant related calcium binding protein (Sorcin) plays an important role in tumor progression, angiogenesis, met...
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
Advancing miRNA cancer research through artificial intelligence: from biomarker discovery to therapeutic targeting
MicroRNAs (miRNAs), a class of small non-coding RNAs, play a vital role in regulating gene expression at the post-transcri...
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