SCI Abstract

search
+
Microbiota metabolite lithocholic acid in cancer: Mechanisms and therapeutic potential
The intestinal microbiota is responsible for the production of a range of bioactive metabolites, and some of them have ant...
KRT15 drives immunosuppression in esophageal squamous cell carcinoma through GSK3β/β-catenin/CD276 signaling
Esophageal cancer (ESCA) ranks as a leading cause of cancer-related morbidity globally, due to its persistently high incid...
The cGAS-STING signaling pathway mediates pyroptosis in colonic epithelial cells and accelerates the progression of CAC
Colorectal cancer (CRC) ranks among the most prevalent and deadly malignancies, contributing significantly to cancer-relat...
ZFP36 and CEBPA are macrophage-associated prognostic biomarkers linked to glomerular endothelial inflammation in ANCA-associated glomerulonephritis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by inflammation of small to mediu...
Age-Dependent Decline in Plasmalogen Biosynthesis Impairs Stress-Induced Mitochondrial Fission in Drosophila
Mitochondrial dysfunction is a central hallmark of aging, contributing to impaired energy production, reduced mitophagy, a...
Metabolic Cell Biology – Do. Or do not. There is no try.
Despite their diversity, these 19 articles share a unifying thread: metabolism is a dynamic, context-dependent process tha...
Rab35 drives the malignant progression of endometrial carcinoma by regulating the nuclear translocation of β-catenin
Endometrial carcinoma (EC) is a leading malignancy of the female reproductive system, and postmenopausal women are most su...
Transcriptomic analysis of cells following decreased mitochondrial DNA-copy number reveals compensatory mechanisms in mitochondrial DNA replication and cellular energetics
Volume 458, Issue 1, 1 May 2026, 114951Author links open overlay panel, , , , , Highlights•Depletion of mtDNA resulted in ...
Transcription factor KLF4 inhibits lung cancer cell growth and metastasis by promoting CYLD-induced TEK deubiquitination
Lung cancer (LC), a malignant tumor originating from the lung tissue, is one of the cancers with the highest morbidity and...
Tumor-suppressive SQLE reprograms metabolic flux: Convergence of aerobic glycolysis and cholesterol pathways in ovarian cancer
Recent statistics show that ovarian cancer is the first leading cause of gynecological cancer deaths [1]. The main reasons...
Agarotetrol attenuates spinal cord injury by targeting PPARγ to modulate microglial activation
Spinal cord injury (SCI) is a life-threatening neurological disorder in which structural destruction and functional failur...
Loss of splicing factor RBM25 promotes the collapse of murine hematopoiesis
Whilst pre-mRNA splicing has been demonstrated to play functional roles in normal hematopoiesis, the potential importance ...
PEX5 integrates the p38 MAPK signaling pathway and taurine metabolism to regulate senescence in lung fibroblasts
Chronic lung diseases represent a significant global health burden, especially among aging populations [1]. Despite consid...
CD73+ mesenchymal stem cell (MSC) transplantation improves pressure ulcer healing by promoting angiogenesis through the HIF-1α/VEGF pathway in diabetic mice
Diabetes ranks as the third most prevalent chronic disease and poses a severe threat to global health, with approximately ...
TRPV4-dependent PI3K–Akt activation mediates hyperosmotic stress–induced cell contraction and myofibroblast differentiation in tubular epithelial cells
Renal tubular epithelial cells are continuously exposed to osmotic pressure fluctuations, which are a fundamental aspect o...
AURKA promotes radioresistance in pancreatic cancer via GSK3β-mediated PTEN phosphorylation at T366
Radioresistance is a major therapeutic challenge in clinical management of pancreatic ductal adenocarcinoma (PDAC), yet th...
H3K27 acetylation activated-CYP1B1 promotes invasion, migration and radioresistance in gastric cancer via p38 MAPK-mediated fatty acid metabolism
Gastric cancer (GC) is the fifth commonest malignant tumor in the world, which ranks third in all cancer-related deaths [1...
In vitro dynamics of oyster hemocytes in plasma-based primary cultures
Hemocytes are specialized cells found in the circulatory system of invertebrates, such as marine bivalves, and play crucia...
Neutrophil-mediated alteration of CXCL1/IL-8/AR signaling promotes prostate cancer cell proliferation
The role of immune cells, particularly neutrophils, in the prostate cancer (PCa) progression remains poorly understood. In...
Single-cell transcriptional profiling reveals PAX5-mediated naïve B cell differentiation defect in severe adenoid hypertrophy
Adenoid hypertrophy is the most common cause of upper airway obstruction in pediatric populations, and is associated with ...
DDB1 promotes pituitary adenoma progression by enhancing PAK1-mediated aerobic glycolysis
Pituitary adenoma (PA) originates from the adenohypophysis and is one of the common intracranial tumors [1], accounting fo...
PAI-1 regulates extracellular matrix remodeling and alters fibroblast profibrotic ability in skeletal muscle repair
Skeletal muscle fibrosis frequently occurs in severe muscle injuries, muscular dystrophies and aging process, leading to p...
DNAJC6 in acute kidney injury: A novel target for protecting renal tubular epithelial cells through PGC-1α-mediated mitochondrial homeostasis
Acute kidney injury (AKI) is a prevalent and severe renal disease characterized by high morbidity, mortality, and substant...
Analysis of the in vitro response of the Sapajus cay (Primates: Platyrrhini) genome to exposure to the radiomimetic bleomycin
Bleomycin (BLM, CAS No. 9041-93-4) is a well-established antitumor and antibiotic agent commonly used as a positive contro...
TFPI and ROCK1 serve as the key genes in the vasculogenic mimicry-related prognostic nomogram for glioblastoma
Glioblastoma (GBM) which is the most common malignant brain tumor with poor outcomes accounts for approximately 51 % of in...
Third-trimester trophoblast stem cell function is impaired in fetal growth restriction
Volume 450, Issue 2, 15 July 2025, 114684Author links open overlay panel, , , , , Highlights•Third-trimester SpTSCs have t...
Hypertension-related genes STOM, MEF2C promote proliferation and migration of clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC), represents the predominant subset of renal cell carcinoma (RCC) [1]. Epidemiologi...
Hsa_circ_0081111 promotes the proliferation and metastasis of non-small cell lung cancer by regulating IGF2BP2-mediated stability of Slug mRNA
Globally, lung cancer is the most frequently occurring malignant tumor and the number one cause of cancer-related deaths [...
Role of METTL3 in high glucose-induced trophoblast cell pyroptosis by the CEBPB/miR-96-5p/CCND2 axis via m6A modification
Gestational diabetes mellitus (GDM) could be identified as dramatic glucose fluctuation at the duration of pregnancy, and ...
SIRT7 inhibits osteoclast differentiation in osteoarthritis by mediating NDRG3 deacetylation to suppress the c-Raf/ERK signaling pathway
ObjectiveOsteoarthritis (OA) is the most common type of arthritis, mainly triggered by inflammatory factors secreted by ch...
Load More
format_indent_increase