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Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment
Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment
Transforming growth factor-β (TGF-β) and programmed death-ligand 1 (PD-L1) initiate signaling pathways with co...
Genome‐wide DNA methylation profiling and identification of potential pan‐cancer and tumor‐specific biomarkers
Genome‐wide DNA methylation profiling and identification of potential pan‐cancer and tumor‐specific biomarkers
Abstract DNA methylation alterations have already been linked to cancer, and their usefulness for therapy and diagnosis ha...
ABI1‐based expression signature predicts breast cancer metastasis and survival
ABI1‐based expression signature predicts breast cancer metastasis and survival
Abstract Despite the current standard of care, breast cancer remains one of the leading causes of mortality in women world...
A pipeline for copy number profiling of single circulating tumor cells to assess intra‐patient tumor heterogeneity
A pipeline for copy number profiling of single circulating tumor cells to assess intra‐patient tumor heterogeneity
Abstract Intra-patient tumor heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess...
The immune microenvironment in patients with mismatch‐repair‐proficient oligometastatic colorectal cancer exposed to chemotherapy: the randomized MIROX GERCOR cohort study
The immune microenvironment in patients with mismatch‐repair‐proficient oligometastatic colorectal cancer exposed to chemotherapy: the randomized MIROX GERCOR cohort study
ABSTRACT In the era of immune checkpoint inhibitors, understanding the metastatic microenvironment of proficient mismatch ...
UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines.
UDP‐glucose dehydrogenase expression is upregulated following EMT and differentially affects intracellular glycerophosphocholine and acetylaspartate levels in breast mesenchymal cell lines.
Abstract Metabolic rewiring is one of the indispensable drivers of epithelial–mesenchymal transition (EMT) involved...
Targeting KRAS mutant lung cancer: light at the end of the tunnel
Targeting KRAS mutant lung cancer: light at the end of the tunnel
Abstract For decades, KRAS mutant lung adenocarcinomas (LUAD) have been refractory to therapeutic strategies based on pers...
Cancer outcomes research – a European challenge Part II: Opportunities and priorities
Cancer outcomes research – a European challenge Part II: Opportunities and priorities
ABSTRACT In Part I of our review of cancer outcomes research, we analysed pros and cons of various measures relevant to qu...
Copy number profiling of circulating free DNA predicts transarterial chemoembolization response in advanced hepatocellular carcinoma
Copy number profiling of circulating free DNA predicts transarterial chemoembolization response in advanced hepatocellular carcinoma
Abstract Transarterial chemoembolization (TACE) is the most commonly used treatment for advanced hepatocellular carcinoma ...
Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
Abstract The FAT1 gene functions as a tumor suppressor or promoter, and remains incompletely understood. We examined the c...
Epigenome‐wide three‐way interaction study identifies a complex pattern between TRIM27, KIAA0226 and smoking associated with overall survival of early‐stage NSCLC
Epigenome‐wide three‐way interaction study identifies a complex pattern between TRIM27, KIAA0226 and smoking associated with overall survival of early‐stage NSCLC
Abstract The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27) and smoking has prev...
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer
Abstract Low affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belong...
Deubiquitination of FBP1 by USP7 blocks FBP1–DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors
Deubiquitination of FBP1 by USP7 blocks FBP1–DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors
Poly[ADP-ribose] polymerase (PARP) inhibitors can block DNA single-strand damage repair and subsequently increase double-s...
p53 mutations define the chromatin landscape to confer drug tolerance in pancreatic cancer
p53 mutations define the chromatin landscape to confer drug tolerance in pancreatic cancer
Abstract Somatic inactivation of p53 (TP53) mainly occurs as missense mutations that lead to acquisition of neomorphic mut...
Androgen receptor‐mediated transcriptional repression targets cell plasticity in prostate cancer
Androgen receptor‐mediated transcriptional repression targets cell plasticity in prostate cancer
Abstract Androgen receptor (AR) signaling remains the key therapeutic target in the management of hormone-naïve advan...
Cadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma
Cadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma
Abstract Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The prognosis of patients is v...
KRAS mutation‐independent downregulation of MAPK/PI3K signaling in colorectal cancer
KRAS mutation‐independent downregulation of MAPK/PI3K signaling in colorectal cancer
Abstract KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is “undruggable”, hence efforts h...
Clinical and biological relevance of the transcriptomic‐based prostate cancer metastasis subtypes MetA‐C
Clinical and biological relevance of the transcriptomic‐based prostate cancer metastasis subtypes MetA‐C
Abstract To improve treatment of metastatic prostate cancer, the biology of metastases needs to be understood. We recently...
E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora and HSP90 in preclinical models
E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora and HSP90 in preclinical models
ABSTRACT Cell–cell and cell–matrix adhesion proteins that have been implicated in colorectal epithelial inte...
Integrative analysis of immune related multi‐omics profiles identifies distinct prognosis and tumor microenvironment patterns in osteosarcoma
Integrative analysis of immune related multi‐omics profiles identifies distinct prognosis and tumor microenvironment patterns in osteosarcoma
Abstract Osteosarcoma (OS) is the most common primary malignancy of bone. Epigenetic regulation plays a pivotal role in ca...
Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B cell malignancies
Mcl‐1 and Bcl‐xL levels predict responsiveness to dual MEK/Bcl‐2 inhibition in B cell malignancies
ABSTRACT Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually rel...
Anti‐Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization
Anti‐Chi3L1 antibody suppresses lung tumor growth and metastasis through inhibition of M2 polarization
Abstract Chitinase 3 like 1 (Chi3L1) is associated with various biological processes, such as inflammation, tissue repair,...
Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma
Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma
Abstract Hepatocellular carcinomas (HCCs) usually arise from chronic liver disease (CLD). Pre-cancerous cells in chronical...
Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection
Serial monitoring of genomic alterations in circulating tumor cells of ER‐positive/HER2‐negative advanced breast cancer: feasibility of precision oncology biomarker detection
Abstract Nearly all estrogen receptor (ER)-positive (POS) metastatic breast cancers become refractory to endocrine (ET) an...
Liquid profiling of circulating tumor DNA in colorectal cancer: steps needed to achieve its full clinical value as standard care
Liquid profiling of circulating tumor DNA in colorectal cancer: steps needed to achieve its full clinical value as standard care
ABSTRACT The analysis of circulating tumor DNA (ctDNA) is at the threshold of implementation into standard care for colore...
Detection of gene mutations and gene–gene fusions in circulating cell‐free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis
Detection of gene mutations and gene–gene fusions in circulating cell‐free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis
Abstract Glioblastoma (GBM) is the most common type of glioma and is uniformly fatal. Currently, tumour heterogeneity and ...
Cancer outcomes research—a European challenge: measures of the cancer burden
Cancer outcomes research—a European challenge: measures of the cancer burden
In a mission that aims to improve cancer control throughout Europe, the European Academy of Cancer Sciences has defined tw...
Cyr61 from adipose‐derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin αVβ5
Cyr61 from adipose‐derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin αVβ5
Adipose-derived stem cells (ADSCs) play a vital role in colorectal cancer (CRC) progression, but the mechanism remains lar...
Immune modulation underpins the anti‐cancer activity of HDAC inhibitors
Immune modulation underpins the anti‐cancer activity of HDAC inhibitors
Aberrant protein acetylation is strongly linked to tumorigenesis, and modulating acetylation through targeting histone dea...
Prognostic relevance of longitudinal HGF levels in serum of patients with ovarian cancer
Prognostic relevance of longitudinal HGF levels in serum of patients with ovarian cancer
The pleiotropic protein hepatocyte growth factor (HGF) is the only known ligand of the tyrosine kinase mesenchymal–...
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