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Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models
Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models
Small cell lung cancer (SCLC) represents one of the most aggressive malignancies, featured with its extraordinary metastat...
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors
Recent advances and treatment strategies in liver metastasis of pancreatic neuroendocrine tumors
Pancreatic neuroendocrine tumors (pNETs) are characterized by significant spatial and temporal heterogeneity, exhibiting a...
Spatial omics: applications and utility in profiling the tumor microenvironment
Spatial omics: applications and utility in profiling the tumor microenvironment
Spatial transcriptomics has emerged as a transformative technology in biomedical research, offering unprecedented insights...
Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact
Circulating tumour cells and circulating tumour DNA in head and neck cancer: from molecular insights to clinical impact
Head and neck squamous cell cancers (HNSCC) are a clinically and biologically diverse group of malignancies with limited t...
Ferroptosis at the intersection of radiotherapy and immunotherapy
Ferroptosis at the intersection of radiotherapy and immunotherapy
Immunotherapy and radiotherapy are widely used in the treatments of various cancers. However, their application remains li...
Alternate actions of CDK4/6 inhibitors beyond cell cycle blockade: unexplored roles in therapy resistance 
Alternate actions of CDK4/6 inhibitors beyond cell cycle blockade: unexplored roles in therapy resistance 
Cell cycle dysregulation and the aberrant activation of cyclin-dependent kinases (CDKs) lead to uncontrolled cell prolifer...
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy
One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy
One-carbon (1C) metabolism is a central metabolic network that supports nucleotide biosynthesis, amino acid metabolism, an...
Thrombocytosis in cancer patients: when more is not better—in fact, the opposite
Thrombocytosis in cancer patients: when more is not better—in fact, the opposite
Platelets are key elements of hemostasis which play an important role in pathological processes, especially in the context...
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis
The dual fate of DYRK2 in cancer: balancing the light and dark side of tumorigenesis
Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is emerging as a pivotal player in cancer biology due...
The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment
The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment
Tissue morphogenesis and homeostasis occur at the interface of a fine coordination between cell cycle and differentiation ...
Engineered bone matrix models for understanding breast cancer skeletal metastasis
Engineered bone matrix models for understanding breast cancer skeletal metastasis
Bone is the most common site of metastasis in patients with advanced breast cancer and serves as a reservoir from which se...
The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma
The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores ...
PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results
PD-L1 subpopulations of metastatic urothelial carcinoma demonstrate heterogeneity to chemotherapy: an integrated analysis of digitized trial results
Efforts to translate advances in immunology into anti-cancer immunotherapies have progressed rapidly in recent years. Six ...
Shaping death: how the microbiome regulates tumour cell demise and therapy response
Shaping death: how the microbiome regulates tumour cell demise and therapy response
Cell death is a fundamental process that maintains tissue homeostasis and shapes the tumour microenvironment. Cancer cells...
CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond
CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond
CAR-T cell therapy, which uses endogenous T cells engineered to target specific cancer antigens, is one of the most promis...
Obesity and melanoma: unraveling the paradoxical survival benefit in immunotherapy
Obesity and melanoma: unraveling the paradoxical survival benefit in immunotherapy
The incidence of melanoma has been steadily increasing worldwide, with metastatic disease accounting for a substantial pro...
Dissecting the aberrant vasculature of glioblastoma: mechanisms and therapeutic targets
Dissecting the aberrant vasculature of glioblastoma: mechanisms and therapeutic targets
Glioblastoma (GBM) is a highly aggressive and almost incurable tumor of the central nervous system. The GBM microenvironme...
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Lessons learned from a decade of immune checkpoint inhibition: The good, the bad, and the ugly
Discovering the brakes/checkpoints that cancer places on the immune system to prevent being eradicated led to the 2018 Nob...
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Microenvironment matters: insights from the FOSTER consortium on microenvironment-driven approaches to osteosarcoma therapy
Osteosarcoma (OS), a prevalent malignant bone tumor, has seen limited progress in treatment efficacy and patient outcomes ...
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
State-of-the-art of multidisciplinary approach of bone metastasis-directed therapy: review and challenging questions for preparation of a GEMO practice guidelines
Bone is a common secondary site of dissemination during the course of cancer. Bone metastases (BM) can be associated with ...
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity in retinoblastoma: a literature review
Tumor heterogeneity, characterized by the presence of diverse cell populations within a tumor, is a key feature of the com...
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells for acute leukemias in children: current status, challenges, and future directions
CAR T-cells therapy is seen as one of the most promising immunotherapies for leukemias, since targeting CD19 has revolutio...
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
Lactate metabolism and lactylation in breast cancer: mechanisms and implications
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy subs...
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy
In recent years, increasing evidence has shown that metals play important roles in both innate and adaptive immunity. An e...
Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma
Molecular mechanisms of metastatic peritoneal dissemination in gastric adenocarcinoma
Peritoneal dissemination portends a dismal prognosis in patients with gastric adenocarcinoma in the context of limited eff...
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Nanomaterials in cancer starvation therapy: pioneering advances, therapeutic potential, and clinical challenges
Gaining significant attention in recent years, starvation therapy based on the blocking nutrients supply to cancer cells v...
Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis
Novel immunotherapy for gastric cancer: targeting the CD47–SIRPα axis
Gastric cancer (GC) represents a significant global health challenge, with limited therapeutic options and poor outcomes. ...
The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerability
The invadosome of stem-like cancer cells: metastasis machinery and targetable vulnerability
Despite recent advances in targeted and immuno-therapy, metastasis still kills most cancer patients. Overcoming cancer met...
Opioid use and the risk of cancer incidence and mortality: a systematic review
Opioid use and the risk of cancer incidence and mortality: a systematic review
There is abundant but discrepant scientific literature reporting an effect of opioids on the course of cancer. The Interna...
Role of PLK4 inhibition in cancer therapy
Role of PLK4 inhibition in cancer therapy
Genomic instability is a hallmark of cancer and is associated with tumor progression and therapeutic resistance. Centriole...
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