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A novel matrine derivative exerts antitumor effects against hepatocellular carcinoma by inducing oxidative stress and DNA damage
A novel matrine derivative exerts antitumor effects against hepatocellular carcinoma by inducing oxidative stress and DNA damage
DNA has long been a major target in the development of anticancer drugs. Natural products, as an important source of antit...
Enhanced antitumor activity of atorvastatin and luteolin, with or without doxorubicin, in a solid Ehrlich carcinoma mouse model: modulation of ABC transporters, telomerase, and cancer stem cells
Enhanced antitumor activity of atorvastatin and luteolin, with or without doxorubicin, in a solid Ehrlich carcinoma mouse model: modulation of ABC transporters, telomerase, and cancer stem cells
This study evaluated the antitumor efficacy of atorvastatin (ATO) and luteolin (LUT), administered individually or in comb...
Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma
Trigonelline suppresses the tumor progression via STAT2 signalling pathway in non-Small cell lung carcinoma
Trigonelline, a naturally derived bioactive compound, has gained interest for its potential anticancer properties. This st...
Thymoquinone decreases cell proliferation and immune evasion of breast cancer cells by reducing CD55 and CD114 levels
Thymoquinone decreases cell proliferation and immune evasion of breast cancer cells by reducing CD55 and CD114 levels
Controlling the proliferation and immune evasion of cancer cells can lead to effective strategies for cancer treatment. Th...
Diosmetin overcomes resistance to cisplatin in ovarian cancer by suppressing the MAPK signaling pathway
Diosmetin overcomes resistance to cisplatin in ovarian cancer by suppressing the MAPK signaling pathway
Cisplatin (DDP) is a widely used chemotherapeutic agent for ovarian cancer (OC) therapy. However, the adverse effects and ...
Targeting STAT5A via CRISPR/Cas9 restores TKI sensitivity in resistant chronic myeloid leukemia cells
Targeting STAT5A via CRISPR/Cas9 restores TKI sensitivity in resistant chronic myeloid leukemia cells
Therapeutic resistance to tyrosine kinase inhibitors (TKIs) remains a major challenge in the clinical management of chroni...
Rho/PAK signaling: a key driver of anthracycline and taxane resistance in breast cancer
Rho/PAK signaling: a key driver of anthracycline and taxane resistance in breast cancer
Resistance to anthracyclines and taxanes remains a major barrier to effective breast cancer treatment, particularly in agg...
Exploration of the mechanism by which Ubiquitin-like protein UBD promotes malignant progression of breast cancer
Exploration of the mechanism by which Ubiquitin-like protein UBD promotes malignant progression of breast cancer
Ubiquitin D, a ubiquitin-like protein, functions as a potential tumor promoter in various cancers. However, its biological...
miRNA-mediated resistance mechanisms in prostate cancer: implications for targeted therapy and metastatic progression
miRNA-mediated resistance mechanisms in prostate cancer: implications for targeted therapy and metastatic progression
Prostate cancer (PCa) remains a leading cause of cancer-related morbidity and mortality in men, with progression to castra...
The diverse roles of circular RNAs in cholangiocarcinoma
The diverse roles of circular RNAs in cholangiocarcinoma
Cholangiocarcinoma (CCA) is a malignant tumor that develops in the extrahepatic bile duct, that is, from the left and righ...
Machine learning integration of bulk and single-cell RNA-seq data reveals glycolytic heterogeneity in colorectal cancer
Machine learning integration of bulk and single-cell RNA-seq data reveals glycolytic heterogeneity in colorectal cancer
As one of the most prevalent malignancies worldwide, colorectal cancer (CRC) exhibits a strong metabolic dependency on gly...
Effect of pyrogallol nanocomposite on miRNA and its associated pathways during radiation-induced toxicity in small intestine of irradiated Balb/C mice
Effect of pyrogallol nanocomposite on miRNA and its associated pathways during radiation-induced toxicity in small intestine of irradiated Balb/C mice
Cancer is the abnormal and uncontrolled growth of cells that changes the structure of nearby cells or tissues. Cancer trea...
Targeting Nrf2 in acute myeloid leukemia: an updated review on its role in chemoresistance and emerging therapeutic strategies
Targeting Nrf2 in acute myeloid leukemia: an updated review on its role in chemoresistance and emerging therapeutic strategies
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the clonal expansion of primitive he...
Diosgenin enhances the effect of radiation on head and neck cancer cells through apoptosis induction, G2/M cell cycle arrest, and ROS generation
Diosgenin enhances the effect of radiation on head and neck cancer cells through apoptosis induction, G2/M cell cycle arrest, and ROS generation
Radiotherapy is a cornerstone in treating head and neck cancers, yet its effectiveness is often limited by factors such as...
Exploring the anticancer potential of extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145)
Exploring the anticancer potential of extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145)
This study investigates the cytotoxic effects of R. tridentata extracts on prostate cancer cells, providing insight into i...
The microbiome–cancer axis as a hidden contributor to early-onset tumorigenesis
The microbiome–cancer axis as a hidden contributor to early-onset tumorigenesis
The global incidence of early-onset cancer has surged by nearly 80% over the past three decades, yet the underlying causes...
Pterostilbene as a promising natural anticancer agent in gynecological cancers
Pterostilbene as a promising natural anticancer agent in gynecological cancers
Gynecological cancer, encompassing cancers such as endometrial and cervical cancer, is a growing concern worldwid...
NPY-functionalized niosomes for targeted delivery of margatoxin in breast cancer therapy
NPY-functionalized niosomes for targeted delivery of margatoxin in breast cancer therapy
Neuropeptide Y (NPY) and the voltage-gated potassium channel Kv1.3 are closely associated with breast cancer progression a...
Identifying drug targets and evaluating KLK3-targeted inhibitors for prostate cancer using in-silico and in-vitro approaches
Identifying drug targets and evaluating KLK3-targeted inhibitors for prostate cancer using in-silico and in-vitro approaches
Prostate cancer remains a significant oncological challenge, driven by molecular factors such as KLK3 (kallikrein-related ...
Tumor microenvironment response to neoadjuvant therapy in breast cancer: insights from single-cell and spatial omics
Tumor microenvironment response to neoadjuvant therapy in breast cancer: insights from single-cell and spatial omics
Breast cancer remains a significant public health concern, and neoadjuvant therapy has significantly reconfigured the land...
Non-coding RNAs’ pivotal importance in modulation of cancer sensitivity to Topotecan: a systematic review
Non-coding RNAs’ pivotal importance in modulation of cancer sensitivity to Topotecan: a systematic review
Cancer is one of the leading causes of mortality worldwide. Development of new methods or improving the efficiency of alre...
Bioactive compounds from marine algae in pancreatic cancer therapy: mechanistic insights into fucoidan and phlorotannins: a review
Bioactive compounds from marine algae in pancreatic cancer therapy: mechanistic insights into fucoidan and phlorotannins: a review
Pancreatic cancer is one of the most lethal tumors, marked by a dismal prognosis, few treatment alternatives, and resistan...
Antisense LNA GapmeR targeting hsa-piR-33195 induces antiproliferative and apoptotic effects on human acute myeloid leukemia
Antisense LNA GapmeR targeting hsa-piR-33195 induces antiproliferative and apoptotic effects on human acute myeloid leukemia
Acute myeloid leukemia (AML) is a severe hematologic malignancy caused by the rapid proliferation of myeloid progenitor ce...
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
Investigation of potential anti-metastatic effect of metformin and caffeic acid combination therapy in breast cancer cell line in in-vitro culture model
The invasion and metastasis of cancer cells transform localized cancers into systemic and life-threatening diseases, posin...
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Study of the effect of zinc oxide, selenium, and silver nanoparticles on the expression level of oxidative stress-associated genes in ovarian cancer
Reactive oxygen species (ROS) generated by oxidative stress have emerged as critical factors in the pathophysiology of mal...
Targeting the Hippo and Rap1 signaling pathways: the anti-proliferative effects of curcumin in colorectal cancer cell lines
Targeting the Hippo and Rap1 signaling pathways: the anti-proliferative effects of curcumin in colorectal cancer cell lines
CRC has the third-highest cancer incidence and death. Many human cancers, including colorectal cancer, are connected to ab...
Didemnins as marine-derived anticancer agents: mechanistic insights and clinical potential
Didemnins as marine-derived anticancer agents: mechanistic insights and clinical potential
Didemnins, a class of cyclic depsipeptides derived from marine organisms exhibit notable anticancer properties. Among them...
Advances in surgical management of chronic lymphedema: current strategies and future directions
Advances in surgical management of chronic lymphedema: current strategies and future directions
Lymphedema is a chronic condition caused by the accumulation of protein-rich fluid in the interstitial tissue, resulting i...
PYGO2 promotes resistance to chemotherapy via reducing apoptosis and G2/M cell cycle arrest in esophageal carcinoma cells
PYGO2 promotes resistance to chemotherapy via reducing apoptosis and G2/M cell cycle arrest in esophageal carcinoma cells
5-FU is a widely used chemotherapy drug for esophageal carcinomas, but therapy failure has been observed in 5-FU-resistant...
Emerging nanoplatforms towards microenvironment-responsive glioma therapy
Emerging nanoplatforms towards microenvironment-responsive glioma therapy
Gliomas are aggressive intracranial tumors of the central nervous system with a poor prognosis, high risk of recurrence, a...
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