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Who Truly Benefits from Anti-EGFR Rechallenge in Metastatic Colorectal Cancer? From Clinical Enrichment to ctDNA-Guided Molecular Hyperselection
Who Truly Benefits from Anti-EGFR Rechallenge in Metastatic Colorectal Cancer? From Clinical Enrichment to ctDNA-Guided Molecular Hyperselection
Later-line treatment of metastatic colorectal cancer (mCRC) remains challenging because established salvage options often ...
Beyond Sidedness: DNA Methylation as a Biomarker to Refine Anti-EGFR Treatment Selection in RAS/BRAF Wild-type Metastatic Colorectal Cancer
Beyond Sidedness: DNA Methylation as a Biomarker to Refine Anti-EGFR Treatment Selection in RAS/BRAF Wild-type Metastatic Colorectal Cancer
Primary tumor sidedness is a major determinant of biologic-agent selection in RAS/BRAF wild-type metastatic colorectal can...
Efficacy of Fibrin Sealants and Polyglycolic Acid Sheets in Reducing Postoperative Hemorrhage Following Gastric Endoscopic Submucosal Dissection: A Meta-analysis of Randomized and Observational Studies
Efficacy of Fibrin Sealants and Polyglycolic Acid Sheets in Reducing Postoperative Hemorrhage Following Gastric Endoscopic Submucosal Dissection: A Meta-analysis of Randomized and Observational Studies
Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms with low lymph node metastasi...
Characteristics, Treatments, and Outcomes of Early-Onset Appendiceal Cancer: NCDB Analysis
Characteristics, Treatments, and Outcomes of Early-Onset Appendiceal Cancer: NCDB Analysis
Early-onset appendiceal cancer (EOAC), diagnosed before age 50, accounts for approximately 30% of all appendiceal malignan...
Outcomes of Gastric Cancer Surgery in Nonagenarians Compared With Patients Aged 85–89 Years: a Multi-Institutional Study
Outcomes of Gastric Cancer Surgery in Nonagenarians Compared With Patients Aged 85–89 Years: a Multi-Institutional Study
Several reports have assessed the clinical characteristics of elderly patients aged 85 years or older who had gas...
Adherence to 2020 US Multi-Society Task Force Guidelines for Post-Polypectomy Surveillance: a Multicenter Real-Time Analysis
Adherence to 2020 US Multi-Society Task Force Guidelines for Post-Polypectomy Surveillance: a Multicenter Real-Time Analysis
The U.S. Multi-Society Task Force (USMSTF) updated its 2020 guidelines to recommend less frequent post-polypectomy surveil...
Positioning Zolbetuximab in HER2-Negative Advanced Gastric Cancer: A Practical Framework for Treatment Selection in the ICI Era
Positioning Zolbetuximab in HER2-Negative Advanced Gastric Cancer: A Practical Framework for Treatment Selection in the ICI Era
Claudin 18.2 (CLDN18.2) has rapidly evolved from a biologically attractive target to a clinically actionable biomarker in ...
Understanding Surgery Refusal in Patients with Colorectal Liver Metastases
Understanding Surgery Refusal in Patients with Colorectal Liver Metastases
To investigate the risk factors, reasons, and survival outcomes associated with refusal of surgery for colorectal liver me...
Real-World Survival and Toxicity Outcomes of Fluorouracil With vs. Without Leucovorin in Metastatic Colorectal Cancer
Real-World Survival and Toxicity Outcomes of Fluorouracil With vs. Without Leucovorin in Metastatic Colorectal Cancer
Fluorouracil (5-FU) remains a cornerstone of systemic therapy for metastatic colorectal cancer (mCRC). Leucovorin enhances...
Clinical Outcomes of Second-Line FOLFIRI Plus Ramucirumab According to Prior Biologic Exposure in Metastatic Colorectal Cancer: A Retrospective Comparison of Prior Bevacizumab and Prior Anti-EGFR Cohorts
Clinical Outcomes of Second-Line FOLFIRI Plus Ramucirumab According to Prior Biologic Exposure in Metastatic Colorectal Cancer: A Retrospective Comparison of Prior Bevacizumab and Prior Anti-EGFR Cohorts
Ramucirumab plus FOLFIRI is an established second-line treatment option for metastatic colorectal cancer (mCRC) after oxal...
Prognostic Factors for Cancer-Specific Survival after Recurrence in Chemo-Naïve Stage I–III Colorectal Cancer
Prognostic Factors for Cancer-Specific Survival after Recurrence in Chemo-Naïve Stage I–III Colorectal Cancer
Survival after recurrence in colorectal cancer (CRC) is typically evaluated in adjuvant-treated Stage II–III patient...
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Patients with Esophageal Carcinoma: A Systematic Review and Meta-Analysis
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Patients with Esophageal Carcinoma: A Systematic Review and Meta-Analysis
The optimal approach between perioperative chemotherapy (CT) versus preoperative chemoradiotherapy (CRT) for esophageal ca...
Outcomes of Epidermal Growth Factor Receptor Inhibitors in Locally Advanced and Metastatic Anal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Outcomes of Epidermal Growth Factor Receptor Inhibitors in Locally Advanced and Metastatic Anal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
Anal squamous cell carcinoma (ASCC) is a rare malignancy with rising incidence and limited systemic options in recurrent o...
Reverse-Bevel (ProCore) EUS-Guided Fine-Needle Biopsy for Solid Pancreatic Mass Lesions: a GRADE-Assessed Systematic Review and Meta-Analysis of Prospective Randomized Trials
Reverse-Bevel (ProCore) EUS-Guided Fine-Needle Biopsy for Solid Pancreatic Mass Lesions: a GRADE-Assessed Systematic Review and Meta-Analysis of Prospective Randomized Trials
Endoscopic ultrasound-guided tissue acquisition is used to diagnose pancreatic mass lesions, but optimal needle selection ...
Radiomics Models as Tools for Predicting Genetic Mutations in Colorectal Cancer: A Systematic Review and Meta-Analysis
Radiomics Models as Tools for Predicting Genetic Mutations in Colorectal Cancer: A Systematic Review and Meta-Analysis
The evaluation of genetic mutations is crucial for personalized therapy in colorectal cancer (CRC), but the invasive tissu...
Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature Review
Tumour-Associated Neutrophils in Colorectal Cancer: a Systematic Review, Meta-analysis, and Comprehensive Literature Review
Neutrophils are at the forefront of innate immune response. The prognostic impact of tumour-associated neutrophils (TANs) ...
Inflammation and RNA-Related Polymorphisms in Resected Cholangiocarcinoma: Prognostic Associations in Intrahepatic and Perihilar Tumors
Inflammation and RNA-Related Polymorphisms in Resected Cholangiocarcinoma: Prognostic Associations in Intrahepatic and Perihilar Tumors
Cholangiocarcinoma (CCA) is a heterogeneous and aggressive malignancy of the biliary tract, often classified into intrahep...
Optimal First-Line Immunotherapy for MSI-H/dMMR Metastatic Colorectal Cancer: Evidence, Gaps, and Clinical Decision-Making
Optimal First-Line Immunotherapy for MSI-H/dMMR Metastatic Colorectal Cancer: Evidence, Gaps, and Clinical Decision-Making
Microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC) has emerge...
Treatment Selection Beyond Second Line in Metastatic Colorectal Cancer: Practical Sequencing of Cytotoxic Salvage Therapy, Anti-angiogenic Agents, Rechallenge Strategies, and Biomarker-Guided Treatments
Treatment Selection Beyond Second Line in Metastatic Colorectal Cancer: Practical Sequencing of Cytotoxic Salvage Therapy, Anti-angiogenic Agents, Rechallenge Strategies, and Biomarker-Guided Treatments
Treatment selection beyond second line in metastatic colorectal cancer (mCRC) has evolved from empirical salvage therapy t...
A Higher Risk of Liver Cancer in Alcoholic Fatty Liver Disease than in Non-Alcoholic Fatty Liver Disease: an Analysis of the TriNetX Dabatase
A Higher Risk of Liver Cancer in Alcoholic Fatty Liver Disease than in Non-Alcoholic Fatty Liver Disease: an Analysis of the TriNetX Dabatase
Both alcohol fatty liver disease (AFLD) and non-alcohol fatty liver disease (NAFLD) are established risk factors for liver...
Predicting Tumor Regrowth in Patients Undergoing Non-Operative Management after Total Neoadjuvant Therapy
Predicting Tumor Regrowth in Patients Undergoing Non-Operative Management after Total Neoadjuvant Therapy
Total neoadjuvant treatment (TNT) has become the standard of care for locally advanced rectal cancer (LARC), leading to in...
Recurrent Cytokine Release Syndrome in Metastatic Gastric Cancer on Nivolumab-FOLFOX: A Case Report and Mechanistic Review
Recurrent Cytokine Release Syndrome in Metastatic Gastric Cancer on Nivolumab-FOLFOX: A Case Report and Mechanistic Review
Cytokine release syndrome (CRS) is a hyperinflammatory condition most commonly observed following chimeric antigen recepto...
The Association Between Proton Pump Inhibitor Use and Gastroenteropancreatic Neuroendocrine Tumors: A Systematic Review
The Association Between Proton Pump Inhibitor Use and Gastroenteropancreatic Neuroendocrine Tumors: A Systematic Review
This systematic review evaluated the site-specific association between long-term use of proton pump inhibitors (PPIs) and ...
Exploring Recurrence Patterns of Esophageal Carcinoma Post-Curative Resection: a Comprehensive Study from a High-Volume Oncology Center in India
Exploring Recurrence Patterns of Esophageal Carcinoma Post-Curative Resection: a Comprehensive Study from a High-Volume Oncology Center in India
Carcinoma esophagus is an aggressive malignancy with high recurrence rates even after curative resection. This study aimed...
Resection Margin and Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma: Does Margin Status Matter in Nodal Disease?
Resection Margin and Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma: Does Margin Status Matter in Nodal Disease?
Lymph node metastasis (LNM) is a poor prognostic factor in intrahepatic cholangiocarcinoma (iCCA). However, the clinical b...
Association of Preoperative and Postoperative Serum Albumin Levels with Colorectal Cancer Outcomes: a Retrospective Cohort Study
Association of Preoperative and Postoperative Serum Albumin Levels with Colorectal Cancer Outcomes: a Retrospective Cohort Study
To elucidate the correlation between perioperative serum albumin concentrations and clinical outcomes in patients with col...
Misdiagnosis of Suspected Cancer in Pancreatoduodenectomy: A Systematic Review and Prevalence Mata-Analysis
Misdiagnosis of Suspected Cancer in Pancreatoduodenectomy: A Systematic Review and Prevalence Mata-Analysis
Differentiating between pancreatic cancer (PC) and benign pancreatic lesions is challenging, leading to misdiagnosis and u...
Impact of Abdominal Aortic Calcification on Long-Term Outcome after Gastric Cancer Surgery: a Retrospective Study
Impact of Abdominal Aortic Calcification on Long-Term Outcome after Gastric Cancer Surgery: a Retrospective Study
This study examined the impact of abdominal aortic calcification, a known risk factor for cardiovascular disease, on the p...
Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Early-Onset Colorectal Cancer
Clinicopathological Factors and Nomogram Construction for Lymph Node Metastasis in Early-Onset Colorectal Cancer
Colorectal cancer (CRC) is the most prevalent malignant tumor of the digestive system globally, ranking third in incidence...
From Detection to Delay: Real-World Gaps in Post-Cologuard Colonoscopy Adherence
From Detection to Delay: Real-World Gaps in Post-Cologuard Colonoscopy Adherence
Colorectal cancer remains a leading cause of cancer deaths, highlighting the need for early detection. Cologuard®, a ...
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