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B4GALT5 inhibits CD8+ T-cell response by downregulating MHC-I level through ERAD pathway in PDAC
IntroductionPancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of pancreatic cancer and is one of the most chal...
RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity
IntroductionNatural killer (NK) cells, which are principal constituents of type 1 innate lymphoid cells, serve as the prim...
Combination of HDAC inhibition and cytokine enhances therapeutic HPV vaccine therapy
WHAT IS ALREADY KNOWN ON THIS TOPICTherapeutic cancer vaccines are an active area of investigation towards improving outco...
Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSHere, we determined the therapeutic efficacy of TCRs in a near-clin...
Targeting nerve growth factor: an Achilles heel for tumors?
Over the past decade, there has been a surge of interest in understanding the role of sympathetic nerves in promoting tumo...
Correction: Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors
Nelson BE, O'Brien S, Sheth RA, et al. Phase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination wi...
FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma
IntroductionHepatocellular carcinoma (HCC) is one of the most common malignancies and leading causes of cancer-related dea...
Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis
IntroductionImmune evasion plays a key role in tumor progression, which implies that tumors have potential to establish co...
Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSOur studies suggest that the antitumor activity of the anti-PD-1+LA...
First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE, OR POLICYThe study paves the way for ra...
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
WHAT IS ALREADY KNOWN ON THIS TOPICGlioblastoma (GBM) immunotherapy resistance has been linked primarily to a deficiency i...
iPSC-derived natural killer cells expressing the Fc{gamma}R fusion CD64/16A can be armed with antibodies for multitumor antigen targeting
BackgroundNatural killer (NK) cells are cytotoxic lymphocytes of the innate immune system . These cells express numerous g...
Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer
IntroductionColorectal cancer (CRC) is the third leading cause of cancer worldwide and, despite therapeutic advances, the ...
Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity
BackgroundAlthough immunotherapy, especially immune checkpoint inhibitors, has shown clinical success, its efficacy is oft...
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
BackgroundImmune checkpoint inhibitors (ICIs) mainly include antibodies that targeting programmed cell death protein-1 (PD...
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion
BackgroundIn recent decades, the field of cancer immunotherapy has expanded greatly, leading to improved outcomes for many...
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
IntroductionThe tumor microenvironment (TME) is a complex environment consisting of tumor cells, immune cells, secreted fa...
Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma
IntroductionClear cell renal cell carcinoma (ccRCC) is the most common and malignant histological form of kidney cancer in...
Targeting integrin {alpha}5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition
IntroductionThe development of colorectal cancer (CRC) is a complex process involving interactions between cancer cells an...
Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates anti-PD-L1 immunotherapeutic efficacy via enhancement of Trim21-mediated PD-L1 ubiquitination
BackgroundLung cancer is one of the most common malignancies and the main cause of cancer mortality around the world. Non-...
Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSWe hypothesized that chemoradiotherapy (CRT) could be used safely t...
Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions
WHAT IS ALREADY KNOWN ON THIS TOPICAntibody-mediated targeting of CD1d on multiple myeloma cells was reported to induce an...
Correction: Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes
Balaji A, Hsu M, Lin CT, et al. Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outco...
Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication
IntroductionImmunotherapy has revolutionized cancer treatment, with durable antitumor responses in a subgroup of patients....
Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-{beta} monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors
WHAT IS ALREADY KNOWN ON THIS TOPICTransforming growth factor beta (TGF-β) plays a critical role in the regulation of the ...
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is a malignant tumor and has the fifth highest incidence rate and the second high...
Evaluation of tissue- and plasma-derived tumor mutational burden (TMB) and genomic alterations of interest in CheckMate 848, a study of nivolumab combined with ipilimumab and nivolumab alone in patients with advanced or metastatic solid tumors with high TMB
WHAT IS ALREADY KNOWN ON THIS TOPICTumor mutational burden (TMB) represents the number of somatic mutations in the tumor g...
Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation
BackgroundRadiotherapy (RT) is commonly used as a neoadjuvant approach for locally advanced rectal cancer (LARC) with or w...
Assessment and predictive ability of the absolute neutrophil count in peripheral blood for in vivo CAR T cells expansion and CRS
IntroductionChimeric antigen receptor (CAR) T cell therapy is a promising and precise cellular immunotherapy.1 Genetically...
Randomized, open-label, phase II, biomarker study of immune-mediated mechanism of action of neoadjuvant subcutaneous trastuzumab in patients with locally advanced, inflammatory, or early HER2-positive breast cancer--Immun-HER trial (GOIRC-01-2016)
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSSC trastuzumab induces stromal tumor-infiltrating lymphocytes (sTIL...
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