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E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
E3 ubiquitin ligase BTRC inhibits the proliferation and tumor growth of glioma cells through the NFAT5/AQP4 axis
Ubiquitination is integral to the pathogenesis of various tumors. This study sought to elucidate the role and underlying m...
CGREF1 promotes cancer cell migration and predicts poor prognosis in colorectal cancer
CGREF1 promotes cancer cell migration and predicts poor prognosis in colorectal cancer
Cell growth regulator with EF-hand domain 1 (CGREF1) has been implicated in the upregulation across various cancer types. ...
Quality of life following total neoadjuvant therapy for rectal cancer
Quality of life following total neoadjuvant therapy for rectal cancer
This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LAR...
Intrahepatic cholangiocarcinoma as a unique subtype: key updates from current guidelines
Intrahepatic cholangiocarcinoma as a unique subtype: key updates from current guidelines
Abou-Alfa GK, Sahai V, Hollebecque A, Vaccaro G, Melisi D, Al-Rajabi R et al (2020a) Pemigatinib for previously treated, l...
Cost-effectiveness analysis of pembrolizumab versus chemotherapy in advanced non-small cell lung cancer in China based on real-world studies
Cost-effectiveness analysis of pembrolizumab versus chemotherapy in advanced non-small cell lung cancer in China based on real-world studies
Although pembrolizumab has been shown to be effective, its high price has prevented it from being widely used. Especially ...
Prognostic impact of central nervous system prophylaxis and a simplified BL model in primary testicular lymphoma: a real-world multicenter study
Prognostic impact of central nervous system prophylaxis and a simplified BL model in primary testicular lymphoma: a real-world multicenter study
Primary testicular lymphoma (PTL) is a rare but aggressive form of extranodal lymphoma with a high risk of central nervous...
Immunotherapy with and without radiotherapy following the diagnosis of bone metastasis for stage IV non-small cell carcinoma
Immunotherapy with and without radiotherapy following the diagnosis of bone metastasis for stage IV non-small cell carcinoma
This retrospective study compared the impact of radiotherapy (RT) and immunotherapy (IO) on survival in patients with stag...
Shared decision-making in cancer care in Bangladesh: evidence from a resource-constrained setting
Shared decision-making in cancer care in Bangladesh: evidence from a resource-constrained setting
Shared decision-making (SDM) is a key component of patient-centered cancer care; however, its implementation remains poorl...
Outcomes of conversion surgery following chemotherapy for initially unresectable metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study in Taiwan
Outcomes of conversion surgery following chemotherapy for initially unresectable metastatic pancreatic ductal adenocarcinoma: a retrospective cohort study in Taiwan
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a high mortality rate. For patients with metastatic P...
Distinct immunologic kinetics and cytomegalovirus reactivation incidence with rituximab- versus obinutuzumab–bendamustine in follicular lymphoma: a single-center case series study
Distinct immunologic kinetics and cytomegalovirus reactivation incidence with rituximab- versus obinutuzumab–bendamustine in follicular lymphoma: a single-center case series study
Rituximab and obinutuzumab, anti-CD20 monoclonal antibodies, are widely employed for treatment of follicular lymphoma (FL)...
Computational identification of cross-reactive TCR epitopes with ARDitox
Computational identification of cross-reactive TCR epitopes with ARDitox
Cellular immunotherapies, such as those utilizing T lymphocytes expressing native or engineered T cell receptors (TCRs), h...
Immune checkpoint inhibition alters patterns of failure in inoperable stage III non-small cell lung cancer patients treated with chemoradiotherapy
Immune checkpoint inhibition alters patterns of failure in inoperable stage III non-small cell lung cancer patients treated with chemoradiotherapy
We compared failure patterns in patients with inoperable stage III non-small cell lung cancer (NSCLC) treated with chemora...
Mapping the frontiers: a bibliometric perspective on t cell-based immunotherapy in pancreatic cancer since the twenty-first century
Mapping the frontiers: a bibliometric perspective on t cell-based immunotherapy in pancreatic cancer since the twenty-first century
T-cell immunotherapy is reshaping cancer care and offers a targeted strategy for pancreatic carcinoma (PC), yet a comprehe...
Prognostic impact of extranodal extension in oral cavity cancers: a retrospective analysis and implications for treatment intensification
Prognostic impact of extranodal extension in oral cavity cancers: a retrospective analysis and implications for treatment intensification
Extranodal extension (ENE) and positive surgical margins are recognized high-risk factors in head and neck cancers. Despit...
Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention
Fertility-sparing treatment for overweight patients with early-stage endometrial cancer or atypical endometrial hyperplasia under weight loss intervention
To evaluate various body fat indicators under weight management on the time to complete response (CR) in overweight patien...
DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma
DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma
Vasculogenic mimicry (VM), a process in which cancer cells form endothelial cell-independent vascular networks, is a hallm...
A clinical report and analysis of metachronous multiple primary cancers occurred in four sites
A clinical report and analysis of metachronous multiple primary cancers occurred in four sites
This case report describes a rare occurrence of quadruple primary malignancies—specifically, bilateral primary breas...
Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis
Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis
Bone mineral density (BMD) plays a crucial role in diagnosing and treating various systemic chronic diseases. Patients wit...
Chronic lymphocytic leukemia (CLL) screening and abnormality detection based on multi-layer fluorescence imaging signal enhancement and compensation
Chronic lymphocytic leukemia (CLL) screening and abnormality detection based on multi-layer fluorescence imaging signal enhancement and compensation
Fluorescence in situ hybridization (FISH) plays a critical role in cancer screening but faces challenges in signal clarity...
Should lymphadenectomy be recommended in radical surgery of intrahepatic cholangiocarcinoma patients? A retrospective study
Should lymphadenectomy be recommended in radical surgery of intrahepatic cholangiocarcinoma patients? A retrospective study
Intrahepatic cholangiocarcinoma (ICC) is an extremely deadly cancer with high recurrence incidence, particularly in patien...
Correction: Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma
Correction: Recombinant human endostatin improves anti-tumor efficacy of paclitaxel by normalizing tumor vasculature in Lewis lung carcinoma
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation
Telomere length and telomerase reverse transcriptase gene polymorphism as potential markers of complete chimerism and GvHD development after allogeneic haematopoietic stem cell transplantation
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase that maintains genome stability by maintainin...
A novel strategy for sorafenib-resistant hepatocellular carcinoma: autotaxin Inhibition by PF-8380
A novel strategy for sorafenib-resistant hepatocellular carcinoma: autotaxin Inhibition by PF-8380
By inhibiting the conversion of lysophosphatidylcholine into lysophosphatidic acid, a process pivotal to tumor progression...
Elevated platelet distribution width and diabetes may serve as preoperative predictors of microvascular invasion in primary hepatocellular carcinoma
Elevated platelet distribution width and diabetes may serve as preoperative predictors of microvascular invasion in primary hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the malignancies with increasing incidence globally, and microvascular invasion (...
Upstream stimulating factor 1 (USF1) -202 G/A polymorphism and serum levels of USF1 and USF2 are associated with gastric cancer risk: a case control study
Upstream stimulating factor 1 (USF1) -202 G/A polymorphism and serum levels of USF1 and USF2 are associated with gastric cancer risk: a case control study
Gastric cancer is an inflammation-driven disease often associated with a bad prognosis. Upstream stimulatory factors USF1 ...
Developing and validating a prognostic disulfidptosis-related signature for glioblastoma: predicting radioresistance and synergestic effect with immunotherapy
Developing and validating a prognostic disulfidptosis-related signature for glioblastoma: predicting radioresistance and synergestic effect with immunotherapy
Programmed cell death (PCD) modulated radioresistance is one of the predominant causes of treatment failure in glioblastom...
Extracellular NAD levels are associated with CD203a expression on Th17 cells and predict long-term recurrence-free survival in hepatocellular carcinoma
Extracellular NAD levels are associated with CD203a expression on Th17 cells and predict long-term recurrence-free survival in hepatocellular carcinoma
Mortality rates for hepatocellular carcinoma (HCC) remain high, while multimodal treatment approaches offer new perspectiv...
Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression
Elevated VRK1 levels after androgen deprivation therapy promote prostate cancer progression by upregulating YAP1 expression
Vaccinia-related kinase 1 (VRK1) is a serine-threonine kinase involved in the proliferation and migration of various cance...
NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization
NSUN5 promotes cholangiocarcinoma progression by enhancing GLS mRNA stabilization
NSUN5, also known as NOP2/Sun domain 5, is a pivotal RNA methyltransferase that catalyzes the formation of 5-methylcytosin...
Genomic analysis of small renal masses reveals mutations linked with renal cell carcinoma and fast-growing tumors
Genomic analysis of small renal masses reveals mutations linked with renal cell carcinoma and fast-growing tumors
Small renal masses (SRMs) SRMs are a heterogeneous group of small kidney lesions. Currently, the genomic landscape of SRMs...
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