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The benefit of deep genomic testing for asymptomatic high-risk individuals undergoing surveillance for pancreatic adenocarcinoma: European registry for hereditary pancreatic diseases (EUROPAC-PLUS)
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From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC
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Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach
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Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR-engineered MLL-rearranged leukemia model
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A MYC family switch: L-MYC drives and maintains neuroendocrine lineage programs in prostate cancer
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Pancreatic metastases are suppressed by photodynamic therapy and irinotecan through macrophage reprogramming in immunodeficient mice
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Metabolic regulation of histone acetylation by ACLY supports MDR1 expression in colorectal cancer and highlights a targetable vulnerability
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Corrigendum to: The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism
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Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology
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Quantitative dissection of radioresistance in cancer cells: Oxygen depletion-induced biological versus chemical mechanisms and baseline mechanisms governed by HIF-1β-NRF2/TXNRD1
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Cancer-associated fibroblast-derived protein S100-A11 influences the response to anti-HER2 therapies in HER2-positive breast cancer
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BRCA1 deficiency induces NFκB-dependent type-I interferon signaling in fallopian tube epithelial cells
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Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer
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Contribution of the immune bone marrow microenvironment to tumor growth and bone deconstruction: implications for improving immunotherapeutic strategies in bone metastasis
Volume 69, November 2025, 101224Author links open overlay panel, , , , AbstractBone metastases are frequent complications ...
PDGFRA in paediatric high-grade glioma – target or distraction?
Volume 69, November 2025, 101231Author links open overlay panel, , , , AbstractPaediatric high-grade gliomas (pHGGs) are a...
Steatohepatitis alters lymphocytes cytotoxicity and localization, accelerating colorectal liver metastases
Volume 69, November 2025, 101222Author links open overlay panel, , , AbstractBackground & AimsThe liver is the most co...
Targeting lysosomal protease CTSL promotes anti-tumor immunity and sensitizes HNSCC to PD-1 blockade by stabilizing PDK1 and activating Akt–PD-L1 axis
Cathepsin L (CTSL) is expressed in head and neck squamous cell carcinoma (HNSCC), yet its role in immune escape is unclear...
Proteomic analysis uncovers biological diversity in molecularly defined endometrial carcinomas
While endometrial cancer has an overall favorable prognosis, some patients have poor outcomes and may benefit from further...
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA
Volume 69, November 2025, 101227Author links open overlay panel, , , , , , , , , , , , , , AbstractBackgroundThe poor prog...
A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate
Volume 69, November 2025, 101230Author links open overlay panel, , , , , AbstractAndrogen deprivation therapy (ADT) remain...
GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape
Volume 69, November 2025, 101232Author links open overlay panel, , , , , , AbstractOsteosarcoma is a common malignant bone...
Generation of orthotopic intracranial glioblastoma patient-derived xenograft models: insights into extrachromosomal DNA-driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic evaluation
Volume 69, November 2025, 101233Author links open overlay panel, , , , , , , , , , , , , , , AbstractBackgroundThis study ...
PD-L1(+) tumor-associated macrophages induce CD8(+) T Cell exhaustion in hepatocellular carcinoma
Volume 69, November 2025, 101234Author links open overlay panel, , , , , , , , , , , Highlights•PD-L1(+) TAMs exhibit immu...
Corrigendum to “Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states” [Neoplasia 66 (2025) 1101189]
Volume 69, November 2025, 101226Author links open overlay panelMohamed Kamal a, Stephanie N. Shishido a, Jeremy Mason a d ...
Ovulation releases G-CSF to induce peritoneal neutrophil influx and netosis, facilitating peritoneal seeding of high-grade serous carcinoma
Volume 70, December 2025, 101236Author links open overlay panel, , , , , AbstractIntroductionHigh-grade serous ovarian can...
Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer
Volume 70, December 2025, 101235Author links open overlay panel, , , , , , , , , , , , , , , , AbstractAdvanced prostate c...
RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells
Volume 70, December 2025, 101237Author links open overlay panel, , , , Highlights•BRCA1 mutation status influences cytokin...
6-aminonicotinamide, a G6PD inhibitor, mitigates CAPS1 reduction mediated HCC metastasis via ERK and GSK3β signals
Volume 70, December 2025, 101239Author links open overlay panel, , , , , , , , , , AbstractRedirecting glucose into the pe...
Adverse prognosis of GM-CSF expression in human cutaneous melanoma
BackgroundGM-CSF, a myeloid-priming cytokine, exhibits context-dependent effects on tumor growth and, despite its clinical...
FER kinase governs invasive growth of head and neck squamous cell carcinoma through dynamic control of growth factor receptor activity
Volume 70, December 2025, 101241Author links open overlay panel, , , , , , , , , , , , , Highlights•FER, a non-receptor ty...
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