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Contribution of the immune bone marrow microenvironment to tumor growth and bone deconstruction: implications for improving immunotherapeutic strategies in bone metastasis
Volume 69, November 2025, 101224Author links open overlay panel, , , , AbstractBone metastases are frequent complications ...
PDGFRA in paediatric high-grade glioma – target or distraction?
Volume 69, November 2025, 101231Author links open overlay panel, , , , AbstractPaediatric high-grade gliomas (pHGGs) are a...
Steatohepatitis alters lymphocytes cytotoxicity and localization, accelerating colorectal liver metastases
Volume 69, November 2025, 101222Author links open overlay panel, , , AbstractBackground & AimsThe liver is the most co...
Targeting lysosomal protease CTSL promotes anti-tumor immunity and sensitizes HNSCC to PD-1 blockade by stabilizing PDK1 and activating Akt–PD-L1 axis
Cathepsin L (CTSL) is expressed in head and neck squamous cell carcinoma (HNSCC), yet its role in immune escape is unclear...
Proteomic analysis uncovers biological diversity in molecularly defined endometrial carcinomas
While endometrial cancer has an overall favorable prognosis, some patients have poor outcomes and may benefit from further...
FAM111B enhances glycolysis and promotes metastasis of prostate cancer by upregulating LDHA
Volume 69, November 2025, 101227Author links open overlay panel, , , , , , , , , , , , , , AbstractBackgroundThe poor prog...
A spatiotemporal atlas of orchiectomy-induced androgen deprivation-mediated modulation of cellular composition and gene expression in the mouse prostate
Volume 69, November 2025, 101230Author links open overlay panel, , , , , AbstractAndrogen deprivation therapy (ADT) remain...
GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape
Volume 69, November 2025, 101232Author links open overlay panel, , , , , , AbstractOsteosarcoma is a common malignant bone...
Generation of orthotopic intracranial glioblastoma patient-derived xenograft models: insights into extrachromosomal DNA-driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic evaluation
Volume 69, November 2025, 101233Author links open overlay panel, , , , , , , , , , , , , , , AbstractBackgroundThis study ...
PD-L1(+) tumor-associated macrophages induce CD8(+) T Cell exhaustion in hepatocellular carcinoma
Volume 69, November 2025, 101234Author links open overlay panel, , , , , , , , , , , Highlights•PD-L1(+) TAMs exhibit immu...
Corrigendum to “Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states” [Neoplasia 66 (2025) 1101189]
Volume 69, November 2025, 101226Author links open overlay panelMohamed Kamal a, Stephanie N. Shishido a, Jeremy Mason a d ...
Ovulation releases G-CSF to induce peritoneal neutrophil influx and netosis, facilitating peritoneal seeding of high-grade serous carcinoma
Volume 70, December 2025, 101236Author links open overlay panel, , , , , AbstractIntroductionHigh-grade serous ovarian can...
Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer
Volume 70, December 2025, 101235Author links open overlay panel, , , , , , , , , , , , , , , , AbstractAdvanced prostate c...
RANKL and CSF-1 are elevated in periovulatory follicular fluid of BRCA1 mutation carriers and increase proinflammatory signaling in fallopian tube epithelial cells
Volume 70, December 2025, 101237Author links open overlay panel, , , , Highlights•BRCA1 mutation status influences cytokin...
6-aminonicotinamide, a G6PD inhibitor, mitigates CAPS1 reduction mediated HCC metastasis via ERK and GSK3β signals
Volume 70, December 2025, 101239Author links open overlay panel, , , , , , , , , , AbstractRedirecting glucose into the pe...
Adverse prognosis of GM-CSF expression in human cutaneous melanoma
BackgroundGM-CSF, a myeloid-priming cytokine, exhibits context-dependent effects on tumor growth and, despite its clinical...
FER kinase governs invasive growth of head and neck squamous cell carcinoma through dynamic control of growth factor receptor activity
Volume 70, December 2025, 101241Author links open overlay panel, , , , , , , , , , , , , Highlights•FER, a non-receptor ty...
Cancer stem-like cells stay in a plastic state ready for tumor evolution
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SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer
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ZC3H15 suppression ameliorates bone cancer pain through inhibiting neuronal oxidative stress and microglial inflammation
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors
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YPEL2 regulates the efficacy of BRD4-EZH2 dual targeting in EZH2Y641mut germinal center-derived lymphoma
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial
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Identification of 68 HLA-A24 and -A2-restricted cytotoxic T lymphocyte-inducing peptides derived from 10 common cancer-specific antigens frequently expressed in various solid cancers
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Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export
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MYH knockdown in pancreatic cancer cells creates an exploitable DNA repair vulnerability
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Phase I clinical trial of a novel procaspase-3 activator SM-1 with temozolomide in recurrent high-grade gliomas
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Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis
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STAT signaling in the pathogenesis and therapy of acute myeloid leukemia and myelodysplastic syndromes
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Effect of MisMatch repair deficiency on metastasis occurrence in a syngeneic mouse model
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