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Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms
Regulation of cisplatin resistance in lung cancer by epigenetic mechanisms
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, responsible for nearly 1.8 milli...
Selective disruption of DNMT1/ELK1 interactions induces DGKI re-expression and promotes temozolomide sensitivity of MGMTmethylated/DGKImethylated glioblastoma
Selective disruption of DNMT1/ELK1 interactions induces DGKI re-expression and promotes temozolomide sensitivity of MGMTmethylated/DGKImethylated glioblastoma
DNA methyltransferase (DNMT) inhibitors are emerging as a promising class of agents for personalized and targeted cancer t...
Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers
Epigenetic age acceleration in Turner and Klinefelter syndrome: Correlations with clinical aging markers
The sex chromosome aneuploidies Turner syndrome (45,X; TS) and Klinefelter syndrome (47,XXY; KS) are associated with aging...
Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma
Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma
DNA methylation of CpG islands is altered in cancer cells. Hypermethylation of single CpG islands in the promoter regions ...
Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium
Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studie...
DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations
DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations
The incidence of early-onset colorectal cancer (EOCRC) has been rising at an alarming rate in the USA, and EOCRC dispropor...
Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy
Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy
Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to...
Blood-based epigenome-wide association study and prediction of alcohol consumption
Blood-based epigenome-wide association study and prediction of alcohol consumption
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is ...
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
The role of myocardial energy metabolism perturbations in diabetic cardiomyopathy: from the perspective of novel protein post-translational modifications
Diabetic cardiomyopathy (DbCM), a significant chronic complication of diabetes, manifests as myocardial hypertrophy, fibro...
Epigenetics of the far northern Yakutian population
Epigenetics of the far northern Yakutian population
Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a contine...
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. T...
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecu...
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treat...
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natu...
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. ...
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has bee...
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive cl...
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of...
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and deve...
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis
Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary...
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery i...
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
Metabolomic biomarkers of habitual B vitamin intakes unveil novel differentially methylated positions in the human epigenome
B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methyl...
N6-methyladenosine methylation in kidney injury
N6-methyladenosine methylation in kidney injury
Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and ...
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems
Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progressio...
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells
Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impa...
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Further refinement of the differentially methylated distant lung-specific FOXF1 enhancer in a neonate with alveolar capillary dysplasia
Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80–...
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may a...
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, e...
An epigenetic hypothesis for ovarian cancer prevention by oral contraceptive pill use
An epigenetic hypothesis for ovarian cancer prevention by oral contraceptive pill use
Ovarian cancer is the second most common gynecological cancer type after uterine cancers. In 2020, according to worldwide ...
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