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Emerging trends in the global burden of colorectal cancer
Emerging trends in the global burden of colorectal cancer
Globally, colorectal cancer (CRC) is the third most frequently diagnosed cancer and the second leading cause of cancer-rel...
Synergistic integration of regional and systemic therapies in uveal melanoma
Treatments for metastatic uveal melanoma utilize various liver-directed strategies, yet optimal integration with systemic ...
The transformative role of SBRT in the management of spinal metastases
The transformative role of SBRT in the management of spinal metastases
Spinal metastases can cause disabling pain and neurological deterioration and have historically been treated with palliati...
Liquid biopsy to inform adjuvant decisions during neoadjuvant chemotherapy — a full-circle moment for nasopharyngeal cancer
Liquid biopsy to inform adjuvant decisions during neoadjuvant chemotherapy — a full-circle moment for nasopharyngeal cancer
The historical development of plasma Epstein–Barr virus DNA for informing clinical decisions for patients with nasop...
Pan-RAS inhibitor daraxonrasib shows promise in pancreatic cancer
Chemotherapy remains the mainstay systemic treatment for pancreatic ductal adenocarcinoma (PDAC) and the disease continues...
Clinical implementation of multi-cancer early detection tests: can we find a path forward?
On 3 February 2026, the Nancy Gardner Sewell Medicare Multi-Cancer Early Detection Screening Coverage Act was enacted, ena...
Transforming perioperative treatment of gastro-oesophageal adenocarcinoma: triumphs, setbacks and future horizons
Transforming perioperative treatment of gastro-oesophageal adenocarcinoma: triumphs, setbacks and future horizons
The landscape of gastro-oesophageal adenocarcinoma (GEA) management has undergone substantial transformation over the past...
Current evidence and future directions for KIM-1 as a blood-based biomarker in RCC
Current evidence and future directions for KIM-1 as a blood-based biomarker in RCC
Kidney injury molecule-1 (KIM-1) is overexpressed in renal cell carcinoma (RCC), and consistent shedding of this cell-surf...
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities
Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities
T cells can be reprogrammed with transgenic antigen recognition receptors, including chimeric antigen receptors a...
Maintenance tarlatamab extends overall survival
Patients with newly diagnosed extensive-stage small cell lung cancer (ES-SCLC) typically receive platinum-doublet chemothe...
Neoantigen vaccines at the crossroads: lessons from AMPLIFY-201
Final results from the phase I AMPLIFY-201 trial show that ELI-002 2P, a therapeutic cancer vaccine targeting mutant KRAS,...
MARIPOSA demonstrates overall survival benefit from amivantamab–lazertinib
The third-generation EGFR tyrosine kinase inhibitor (TKI) osimertinib is the standard-of-care first-line therapy for patie...
ALASCCA: an aspirin a day keeps colorectal cancer away
Observational studies suggest that aspirin can reduce the risk of colorectal cancer (CRC) recurrence, but randomized trial...
The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities
The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities
Patients with advanced-stage pancreatic ductal adenocarcinoma (PDAC) predominantly receive chemotherapy, and despite initi...
Transanal TME noninferior to the laparoscopic approach
Patients with resectable mid–low rectal cancers often undergo total mesorectal excision (TME) surgery. Over the past decad...
International approvals of cilta-cel: a lens on CAR T cell regulation
The BCMA-targeted chimeric antigen receptor (CAR) T cell therapy ciltacabtagene autoleucel (cilta-cel) has demonstrated ex...
Cadonilimab is efficacious in HER2-negative advanced-stage G/GEJ adenocarcinomas
Patients with HER2-negative advanced-stage gastric or gastro-oesophageal junction (G/GEJ) adenocarcinomas typically receiv...
Intermediate-affinity CD19-directed CAR T cell product obecabtagene autoleucel demonstrates favourable safety and efficacy in R/R B-ALL
Recent data from the FELIX trial evaluating obecabtagene autoleucel in patients with relapsed and/or refractory B acute ly...
AI accurately identifies targetable alterations in lung cancer histological images
DeepGEM, an artificial intelligence (AI)-based model, accurately predicts the presence of key genomic alterations in histo...
Artificial intelligence in digital pathology — time for a reality check
Artificial intelligence in digital pathology — time for a reality check
The past decade has seen the introduction of artificial intelligence (AI)-based approaches aimed at optimizing several wor...
Less-frequent surveillance is noninferior to annual mammography
Most women with newly diagnosed breast cancer remain alive and recurrence-free for many years after complete surgical rese...
Outcome correlates of approved CD19-targeted CAR T cells for large B cell lymphoma
Outcome correlates of approved CD19-targeted CAR T cells for large B cell lymphoma
CD19-targeted chimeric antigen receptor (CAR) T cells have provided a breakthrough in the treatment of patients with relap...
Patients with uncommon EGFR mutations also benefit from first-line osimertinib
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Chemotherapy in EGFR-mutated NSCLC: optimizing combinations with TKIs and amivantamab
Recent results from the FLAURA2 and MARIPOSA-2 trials underline the continued role of chemotherapy in the treatment of pat...
Personalizing adjuvant therapy for patients with colorectal cancer
Personalizing adjuvant therapy for patients with colorectal cancer
The current standard-of-care adjuvant treatment for patients with colorectal cancer (CRC) comprises a fluoropyrim...
Combination neoadjuvant therapies are paving the way for bladder preservation to become the standard for selected patients
Neoadjuvant cisplatin-based combination chemotherapy followed by radical cystectomy with pelvic lymphadenectomy is the cur...
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell malignancies or relapsed and/or...
From the ESMO Congress 2023
As in 2017, this year’s ESMO Congress brought many members of the oncology community together in Madrid, this time with &g...
Computational immunogenomic approaches to predict response to cancer immunotherapies
Computational immunogenomic approaches to predict response to cancer immunotherapies
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The establishment of large-scale genomic ...
THOR provides new data on the efficacy of erdafitinib
The outcomes of patients with metastatic urothelial carcinoma (mUC) and non-muscle invasive urothelial carcinoma (NMIBC) f...
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