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Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion
Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion
Immune evasion is one of the hallmarks of cancers, including glioblastoma, the most aggressive form of primary brain tumor...
FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer
FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer
Disulfidptosis represents a novel type of regulated cell death induced by excessively high intracellular levels of cystine...
Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction
Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction
Sepsis, a life-threatening condition characterized by organ dysfunction due to dysregulated host response to infection, re...
Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle
As the global population trends toward aging, the number of individuals suffering from age-related debilitating diseases i...
Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis
Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis
Ischemic heart disease remains a leading cause of morbidity and mortality worldwide, with myocardial ischemia–reperf...
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear. In this study, we ut...
Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes
Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes
Pulmonary hypertension (PH) presents a puzzling sex bias, being more prevalent in women yet often less severe than in men,...
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression
Maternal overnutrition, prevalent among women of childbearing age, significantly impacts offspring health throughout their...
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu....
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity. Regulator of G protein signalin...
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
METTL3/YTHDC1-medicated m6A modification of circRNA3634 regulates the proliferation and differentiation of antler chondrocytes by miR-124486-5-MAPK1 axis
The deer antler, a remarkable mammalian appendage, has a growth rate surpassing that of any other known osseous organ. Eme...
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease
Alzheimer’s disease (AD) is a chronic illness marked by increasing cognitive decline and nervous system deterioratio...
Metabolite itaconate in host immunoregulation and defense
Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune ce...
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study
This study aims to explore the emerging trends, dynamic development, and research hotspots of clustered regularly interspa...
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not ...
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been&nb...
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, ...
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Ast...
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a f...
Cellular senescence in skeletal disease: mechanisms and treatment
Cellular senescence in skeletal disease: mechanisms and treatment
The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endoc...
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential...
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
To investigate the mechanism of action of Srg3 in acute lung injury caused by sepsis. First, a sepsis-induced acute lung i...
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Hypervirulent Klebsiella pneumoniae (hvKp) infection-induced sepsis-associated acute lung injury (ALI) has emerged as a si...
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis...
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Mitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival....
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However,...
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in ca...
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of ...
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